Now showing items 122-141 of 191
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Peroxiredoxins in Redox Signaling and Aging
(2017-10-23)Peroxiredoxins have emerged as conserved modulators of the rate of aging in yeast and multicellular organisms and play a role in lifespan extension through the anti-aging intervention caloric restriction. Yet, it is not ... -
Photocatalysis beyond conventional precious metal complexes
(2022-11-08)Precious metals, e.g. Ru and Ir, are expensive, scarce and non-renewable resources. As oppose to many renewable resources, these cannot be deliberately produced wherever one wishes. The mining of these metal ores is ... -
Photoredox catalysis harnessing oxygen-centered radicals
(2023-04-04)Visible light provides an abundant and renewable source of energy with an ample capacity to mediate chemical transformations. Photoredox catalysis utilizes this energy for the generation of high-energy radical intermediates ... -
Plant aquaporin regulation: Structural and functional studies using diffraction and scattering techniques
(2015-03-27)Water is the basis for life as we know it. It is only logical then that all organisms have evolved specialized proteins, aquaporins, which regulate water flow across their membranes. Plants, which are immobile, depend more ... -
Preharvest Conditions Affecting Apple Quality, Antioxidant Responses and Susceptibility to the Infection by Grey mould (Botrytis cinerea)
(2020-05-20)Apple fruits are rich in vitamin C and other antioxidants, which are beneficial for human health. During postharvest storage, there are losses as a result of diseases such as grey mould, caused by the fungus Botrytis ... -
Preserving Genetic Integrity in Reproduction: Insights from Telomere Protection and Sperm Head-Tail Junctions
(2023-11-03)This doctoral thesis embarks on a meticulous exploration of genetic integrity within the expansive domain of reproductive biology. Its overarching objective is to decipher the intricacies that underlie the preservation of ... -
Probing the subcellular molecular architecture and turnover of neural cell models using correlative mass spectrometry imaging
(2024-02-28)Neurons are fascinating cellular units of the nervous system and are responsible for the propagation of signals that let us move and think. Understanding cellular mechanisms that maintain neurons and enable their communication ... -
Production and Characterisation of Aquaporins and Proton-Translocating Transhydrogenase
(2013-11-15)Dissertation Abstract Water transport in eukaryotic cells is a highly regulated and fine-tuned process. Water channel protein known as aquaporins (AQPs), constitute the main cellular water transport system, preserving ... -
Production and Structural Dynamics of Microbial Rhodopsins
(2019-05-22)Rhodopsins are a family of membrane proteins that are found in a wide range of organisms and provide them with the ability to sense and react to light. When light is absorbed by these proteins, structural changes occur ... -
Protein Structural Dynamics Revealed by Time-Resolved X-ray Solution Scattering
(2020-02-11)Proteins fold in very specific three-dimensional structures within a few seconds. Highly complex and organized, their three-dimensional structure is closely related and often essential for their function. They perform a ... -
Proteostasis and Aging in Saccharomyces cerevisiae - The role of a Peroxiredoxin
(2017-08-25)Aging is characterized by a progressive decline in physiological functions that limits biological processes, increases the risk of disease, and ultimately leads to death. At the cellular level, aging is associated with ... -
Proteostasis during arsenite stress in Saccharomyces cerevisiae
(2022-11-02)Around 200 million people are exposed to high levels of arsenic through contaminated soil and, consequently, contaminated food and drinking water. Arsenic exposure is associated with several malignancies, from different ... -
Purine and Pyrazolopyrimidine Derivatives: Design and Synthesis of Chemical Tools for Biological Applications
(2014-12-04)Purines can be found in a multitude of naturally occurring compounds with a range of functions. This thesis describes the design and synthesis of purines and structurally related pyrazolopyrimidine derivatives intended for ... -
Quantitative chemical imaging to study content release from single nanovesicles
(2023-12-05)Cellular communication is vital for the survival of multicellular organisms. This process often relies on a highly regulated mechanism called exocytosis, which involves the release of chemical signals. During exocytosis, ... -
Quantitative NanoSIMS provides subcellular concentration and distribution of oligonucleotide therapeutics
(2023-04-28)Antisense oligonucleotides (ASOs) represent a powerful therapeutic modality that can selectively modulate gene expression. However, ASOs face two major hurdles that restrict their use in the clinic. The first issue is ... -
Quantum dynamical effects in complex chemical systems
(2020-05-12)When using mathematical models to computationally investigate a chemical system it is important that the methods used are accurate enough to account for the relevant properties of the system and at the same time simple ... -
Quantum Force in Wigner Space
(2014-04-08)In this thesis, I will present effective methods to study quantum dynamics using trajec- tories. Our methods are based on a method named the Classical Wigner model which starts with a quantum initial condition and generates ... -
Regulation and transport mechanisms of eukaryotic aquaporins
(2013-01-11)Aquaporins are found in all kingdoms of life where they are involved in water homeostasis. They are small transmembrane water conducting channels that belong to the ancient protein family Major Intrinsic Proteins (MIP). ... -
Regulators of Membrane Fluidity
(2020-04-29)Caenorhabditis elegans PAQR-2 (a homolog of the mammalian AdipoR1 and AdipoR2 proteins) and IGLR-2 (homolog of the mammalian LRIG proteins) form a complex at the plasma membrane that regulates fatty acid desaturation to ... -
Revealing functional details of the mitochondrial Lon Protease by NMR spectroscopy
(2023-05-11)Det mänskliga Lon-proteinkomplexet är ett ATP-beroende proteas som finns i den mitokondriella matrisen. Lon-proteinet är en produkt av den kärnkodade genen LONP1 och spelar en avgörande roll i underhåll och reparation ...