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Peroxiredoxins in Redox Signaling and Aging

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Title: Peroxiredoxins in Redox Signaling and Aging
Authors: Roger, Friederike
Issue Date: 23-Oct-2017
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry and Molecular Biology ; Institutionen för kemi och molekylärbiologi
Parts of work: Bodvard, K., Peeters, K., Roger, F., Romanov, N., Igbaria, A., Welkenhuysen, N., ... & Molin, M. (2017). Light-sensing via hydrogen peroxide and a peroxiredoxin. Nature Communications, 8, 14791.

Hanzén, S., Vielfort, K., Yang, J., Roger, F., Andersson, V., Zamarbide-Forés, S., ... & Liu, B. (2016). Lifespan control by redox-dependent recruitment of chaperones to misfolded proteins. Cell, 166(1), 140-151.

Roger, F., Asami, C., Hanzén, S., Lagniel, G., Labarre, J., Nyström, T., and Molin, M. (2017) Redox signaling via the yeast peroxiredoxin Tsa1 promotes longevity by inhibiting nutrient signaling Manuscript
Date of Defence: 2017-11-03
Disputation: Fredagen den 3. november 2017, kl. 10:00 i föreläsningssal Ragnar Sandberg, Medicinaregatan 7
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: Aging
Redox Signaling
Caloric restriction
light sensing
Abstract: Peroxiredoxins have emerged as conserved modulators of the rate of aging in yeast and multicellular organisms and play a role in lifespan extension through the anti-aging intervention caloric restriction. Yet, it is not clear through what mechanism peroxiredoxins extend lifespan. First discovered as hydrogen peroxide scavengers, peroxiredoxins have been shown to have a genome protective function, to act as chaperones, to play a role in circadian rhythms and to be involved in redox signalin... more
ISBN: 978-91-629-0329-9
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi



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