• Computational tools for the analysis of time-resolved serial X-ray crystallography data. 

  Vallejos, Adams (2024-11-22)

  Many transmembrane proteins play an essential role by facilitating energy transduction in various biological systems. Whether powered by light, as in bacteriorhodopsin or photosynthetic reaction centres, or by oxygen ...

• A tale of two songs: oligomeric and monomeric functions of the molecular chaperone CCT 

  Córdoba Beldad, Carmen Maria; Córdoba Beldad, Carmen Maria (2024-11-07)

  The chaperonin-containing tailless complex polypeptide 1 (CCT) is a 1 MDa barrel shaped molecular chaperone present in the cytoplasm of all eukaryotes. Eight different subunits, located in a fixed position, form CCT, which ...

• Emerging roles and functional mechanisms of dynein light chain DYNLRB1 and DYNLRB2 

  shuwen, he (2024-10-28)

  Dyneins are a class of molecular ATPase motors that generate force and movement on microtubules in a wealth of biological processes, including organelle distribution, cell division, ciliary beating, and flagella motility, ...

• Toward the synthesis and characterization of bioactive peptides: Engineering of transmembrane peptide conjugates for targeted drug delivery 

  Abujubara, Helal (2024-10-09)

  Under det senaste decenniet har intresset för terapeutiska peptider inom läkemedelsindustrin växt stort. Idag finns det upp åt 60 olika peptider som är godkända och används globalt på kliniker. Detta tack vare nya produktions-, ...

• The Impact of Arsenic on Protein Homeostasis and Aggregation in Saccharomyces cerevisiae 

  Lorentzon, Emma (2024-09-30)

  Arsenic and cadmium are two toxic heavy metals that occur naturally in bedrock. Arsenic is found in high concentrations in certain areas and can contaminate groundwater, leading to exposure through drinking water and crop ...

• Unveiling Latent Variables Affecting Protein Interactions Using Survivin as a Model Protein 

  Anindya, Atsarina Larasati (2024-09-17)

  Proteins are typically viewed as a sequence of amino acids, where the sequence dictates folding into specific shapes to carry out distinct biological tasks by interacting with specific partners as a consequence of their ...

• Conformational dynamics of rhodopsins revealed through time-resolved X-ray structural studies 

  Ostojić, Lucija; Ostojić, Lucija (2024-09-12)

  Light plays a crucial role in shaping biological processes, influencing growth, behavior, and survival from microorganisms to complex animals. At the molecular level, specialized proteins detect and respond to light, ...

• Atmospheric oxidation of volatile organic compounds and its contribution to aerosol formation 

  Li, Linjie (2024-09-05)

  The atmospheric oxidation of volatile organic compounds (VOC) produces lower-volatility products that can contribute to the formation of secondary organic aerosol (SOA) via gas-to-particle transformation. SOA accounts ...

• Development of antibody-targeted concepts for immunomodulation, biomarker imaging and enzymatic evaluation of bioresponsive pseudoglucosinolates 

  Ganskow, Charity (2024-08-23)

  Nature’s vast biodiversity and its complex biological systems have long been an inspirational source for drug development. A wealth of potent, life-saving substances has been found in nature and learning from nature’s ...

• Role of STE20-Type Kinases in Liver Lipid Metabolism and Hepatocarcinogenesis: Insights from In Vitro and In Vivo Studies 

  Ying, Xia (2024-08-13)

  Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a leading cause of chronic liver disease worldwide, affecting approximately 30% of the adult population. Up to 20% of individuals with MASLD ...

• Characterization of Eukaryotic Aquaporin Regulation 

  Glas, Jessica (2024-05-15)

  Aquaporins, as transmembrane proteins essential for cellular water balance maintenance, are increasingly recognized for their modulation by protein-protein interactions, often implicated in various human pathologies. This ...

• Revealing functional details of molecular machines by NMR spectroscopy 

  Lidman, Jens (2024-05-13)

  Since the development of the nuclear magnetic resonance method, the capability to unravel the dynamical properties and underlying functions of proteins has improved. By studying proteins in solution and utilizing advanced ...

• Toxic Metals and Proteostasis – Molecular mechanisms of arsenite and cadmium-induced protein aggregation in Saccharomyces cerevisiae 

  Andersson, Stefanie (2024-04-16)

  Cadmium and arsenite are common environmental pollutants; considered highly toxic and pose a substantial threat to human health with millions of people worldwide being at risk of exposure. Cadmium and arsenite are carcinogenic ...

• Probing the subcellular molecular architecture and turnover of neural cell models using correlative mass spectrometry imaging 

  Lork, Alicia Andrea (2024-02-28)

  Neurons are fascinating cellular units of the nervous system and are responsible for the propagation of signals that let us move and think. Understanding cellular mechanisms that maintain neurons and enable their communication ...

• Analytical Approaches to Study Vesicular and Exosomal Release 

  Le Vo, Kim Long (2024-02-09)

  Vesicles, as a special type of entity nanometers in size, are crucial for survival of multicellular organisms. Intracellular vesicles mainly contain specific signaling molecules, transmitters, and modulators whereas ...

• The Effect of Site-Specific Mutations on hIAPP Fibril Polymorphism: A Cryo-EM Study Towards Potential Inhibitors 

  Saik Ann, Ooi (2024-01-25)

  The development of amyloid deposits in tissues, as a consequence of the self-assembly of misfolded proteins, is a critical pathological feature in a range of diseases, including neurodegenerative disorders and metabolic ...

• Development and application of Time-of-flight secondary ion mass spectrometry (ToF-SIMS) for skin permeation studies 

  Munem, Marwa (2024-01-08)

  The skin accounts for approximately 16% of human body weight, with a surface area of approximately 2 m2 in adults. It provides a physical barrier to the environment, maintains homeostasis by limiting the loss of water, ...

• How ship exhaust particles change cloud activity 

  Escusa dos Santos, Luis Filipe (2024-01-08)

  The Arctic is experiencing surface warming rates that exceed those observed at lower latitudes. This is caused by a complex system of feedback mechanisms in the Arctic climate system and is referred to as Arctic ...

• Quantitative chemical imaging to study content release from single nanovesicles 

  Nguyen, Tho (2023-12-05)

  Cellular communication is vital for the survival of multicellular organisms. This process often relies on a highly regulated mechanism called exocytosis, which involves the release of chemical signals. During exocytosis, ...

• Preserving Genetic Integrity in Reproduction: Insights from Telomere Protection and Sperm Head-Tail Junctions 

  Zhang, Kexin (2023-11-03)

  This doctoral thesis embarks on a meticulous exploration of genetic integrity within the expansive domain of reproductive biology. Its overarching objective is to decipher the intricacies that underlie the preservation of ...

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