• Microcrystallization and structural studies of proteins by serial crystallography and x-ray scattering 

  Uwangue, Owens (2023-09-20)

  Proteins are the most complex and versatile biomolecules known, with essential roles in all cellular and physiological processes. They constitute the main structural components of cells, catalyze most biochemical reactions, ...

• Emerging roles and functional mechanisms of dynein light chain DYNLRB2 

  He, Shuwen (2023-09-08)

  Dyneins are a small class of molecular ATPase motors that generate force and movement on microtubules in a wealth of biological processes, including organelle distribution, cell division, ciliary and flagella beating, and ...

• Improving integration efficiency and precision of CRISPR/Cas9-mediated genome editing 

  Wimberger, Sandra (2023-09-07)

  The clustered regularly interspaced short palindromic repeats (CRISPR) – CRISPR-associated protein 9 (Cas9) system has revolutionized the field of genome engineering, providing a cost-effective and fast tool for targeted ...

• Structural studies of ba3-type cytochrome c oxidase using serial crystallography and X-ray absorption spectroscopy 

  Zorić, Doris (2023-08-29)

  Cytochrome c oxidase (CcO) catalyses the reduction of molecular oxygen to water while the energy released in this process is used transport protons “up-hill” across an energy transducing biological membrane, creating a ...

• Membrane morphology and homeostasis: An electron microscopy approach 

  Panagaki, Dimitra (2023-06-26)

  Biological membranes allow life as we know it to exist. Primarily assembled from lipids and proteins, their morphology and function can greatly vary between species or even within the same cell. They create physical ...

• Revealing functional details of the mitochondrial Lon Protease by NMR spectroscopy 

  Sallova, Ylber (2023-05-11)

  Det mänskliga Lon-proteinkomplexet är ett ATP-beroende proteas som finns i den mitokondriella matrisen. Lon-proteinet är en produkt av den kärnkodade genen LONP1 och spelar en avgörande roll i underhåll och reparation ...

• Correlative Chemical Imaging of Nanoscale Subcellular Structures 

  Rabasco, Stefania (2023-05-10)

  Chemical imaging can elucidate complex mechanisms, relationships, and components of biological samples. For example, it can reveal properties such as chemical composition, chemical structure, reactivity, and topography. ...

• Mapping ultrastructural effects of proteotoxic stress on S. cerevisiae 

  Keuenhof, Katharina Susanne (2023-05-09)

  Cells are the basic building blocks of any living being, whether the organism consists of only one, or many cells. The different cellular components interact with one another to maintain the viability of the cell. An ...

• Quantitative NanoSIMS provides subcellular concentration and distribution of oligonucleotide therapeutics 

  Becquart, Cécile (2023-04-28)

  Antisense oligonucleotides (ASOs) represent a powerful therapeutic modality that can selectively modulate gene expression. However, ASOs face two major hurdles that restrict their use in the clinic. The first issue is ...

• Multiphoton Microscopy Targeting Tissue Development. Towards the real-time imaging of epidermal differentiation 

  Malak, Monika (2023-04-25)

  The development of novel organ-on-a-chip models calls for methodologies, which will allow the study of tissue development and pharmacological outcome in real-time. Multiphoton microscopy (MPM) has been proposed as a ...

• A Tale of Chaos and Colour Influencing the photophysical properties and glass forming abilities of BODIPY dyes via structural modification 

  Schäfer, Clara (2023-04-04)

  Organic dyes are everyday contributors in chemistry, physics and biology. BODIPY dyes were used as model dye class in this thesis. They are well-known for their versatility, which mainly originates from the tuneability ...

• Photoredox catalysis harnessing oxygen-centered radicals 

  Ondrejková, Alica (2023-04-04)

  Visible light provides an abundant and renewable source of energy with an ample capacity to mediate chemical transformations. Photoredox catalysis utilizes this energy for the generation of high-energy radical intermediates ...

• Simplified Nonsense: New Methods for Interrogating NMD 

  Alalam, Hanna (2023-02-20)

  Nonsense mediated decay (NMD) is a pathway that regulates RNA turnover. Since its discovery, this pathway has been implicated in a variety of cellular processes ranging from differentiation to the restriction of viral ...

• Development and Application of ToF-SIMS for Clinical and Microbiological Analysis 

  Dimovska Nilsson, Kelly (2023-02-15)

  The aim of the work of this thesis was to further the implementation of timeof-flight secondary ion mass spectrometry (ToF-SIMS) in biological analysis and to generate new knowledge from the samples analysed. ToF-SIMS is ...

• Escape from the cage: Ultrafast structural dynamics of photodissociation reactions observed with X-ray solution scattering 

  Nimmrich, Amke

  The environment of a molecule is known to greatly impact the course of a reaction. Such an environment can, for instance, be the solvent in a solution phase reaction or the amino acid residues surrounding a chromophore in ...

• Light and X-ray scattering investigations of microtubules subjected to oscillating electric fields 

  Börjesson, Per (2022-12-08)

  I vårt dagliga liv blir vi utsatta för oscillerande elektriska fält av olika frekvenser. Dessa fält inkluderar mobiltelefoner, wifi, bluetooth, radar för navigering, radar från bilar, kommunikationssatelliter, samt GPS. ...

• Strong exciton-photon and exciton-exciton coupling and its effects on molecular photophysics 

  Yu, Yi (2022-12-05)

  The energy of molecular states and their transition dynamics form the key properties to understand the photophysics of organic molecules. Strong exciton-photon and exciton-exciton couplings enable the possibility to ...

• Functional details of human HtrA2 protease studied by NMR spectroscopy 

  Aspholm, Emelie (2022-11-24)

  Cells rely on an array of cellular machineries in the protein quality control system (PQC) to maintain the health of the collective proteome. The HtrA family of serine proteases are found in all kingdoms of life and function ...

• Formation and Transformation of Atmospheric Brown Carbon (BrC) 

  Mitra, Kalyan (2022-11-23)

  Atmospheric brown carbon (BrC) aerosol absorbs light in the UV-Vis spectrum and has poorly constrained but potentially large climate forcing impacts. Most current climate models lack detailed chemistry and interlinked ...

• Functional roles of protein phase separated assemblies in cellular stress response and proteinopathies 

  Lindström, Michelle Beatrice (2022-11-09)

  For a long time, pertinent biological conundrums, such as the organization and compartmentalization of the cytoplasm and nucleoplasm, perplexed the scientific community. The organization of the complex biochemistry in an ...

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