Department of Chemistry and Molecular Biology / Institutionen för kemi och molekylärbiologi (2012-)
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Recent Submissions
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Probing the subcellular molecular architecture and turnover of neural cell models using correlative mass spectrometry imaging
(2024-02-28)Neurons are fascinating cellular units of the nervous system and are responsible for the propagation of signals that let us move and think. Understanding cellular mechanisms that maintain neurons and enable their communication ... -
Analytical Approaches to Study Vesicular and Exosomal Release
(2024-02-09)Vesicles, as a special type of entity nanometers in size, are crucial for survival of multicellular organisms. Intracellular vesicles mainly contain specific signaling molecules, transmitters, and modulators whereas ... -
The Effect of Site-Specific Mutations on hIAPP Fibril Polymorphism: A Cryo-EM Study Towards Potential Inhibitors
(2024-01-25)The development of amyloid deposits in tissues, as a consequence of the self-assembly of misfolded proteins, is a critical pathological feature in a range of diseases, including neurodegenerative disorders and metabolic ... -
Development and application of Time-of-flight secondary ion mass spectrometry (ToF-SIMS) for skin permeation studies
(2024-01-08)The skin accounts for approximately 16% of human body weight, with a surface area of approximately 2 m2 in adults. It provides a physical barrier to the environment, maintains homeostasis by limiting the loss of water, ... -
How ship exhaust particles change cloud activity
(2024-01-08)The Arctic is experiencing surface warming rates that exceed those observed at lower latitudes. This is caused by a complex system of feedback mechanisms in the Arctic climate system and is referred to as Arctic ... -
Quantitative chemical imaging to study content release from single nanovesicles
(2023-12-05)Cellular communication is vital for the survival of multicellular organisms. This process often relies on a highly regulated mechanism called exocytosis, which involves the release of chemical signals. During exocytosis, ... -
Preserving Genetic Integrity in Reproduction: Insights from Telomere Protection and Sperm Head-Tail Junctions
(2023-11-03)This doctoral thesis embarks on a meticulous exploration of genetic integrity within the expansive domain of reproductive biology. Its overarching objective is to decipher the intricacies that underlie the preservation of ... -
Alkali Uptake and Release from Oxygen Carriers in Chemical Looping Applications: Development and Application of Reactor Systems and Measurement Techniques
(2023-10-31)Chemical looping combustion (CLC) of biomass is a heat and power generation technology with minimal associated costs for carbon capture, potentially resulting in negative CO2 emissions. The CLC technology utilizes fluidized ... -
MST3 and MST4: Critical Regulators of Liver Lipid Partitioning and Hepatocarcinogenesis
(2023-10-25)Non-alcoholic fatty liver disease (NAFLD) encompasses a disease spectrum ranging from hepatic steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, and finally cirrhosis. With no approved pharmacological treatment, ... -
Formation of small molecules in space through the process of radiative association
(2023-10-16)This thesis is dedicated to calculating the reaction rate constants for the formation of molecules through radiative association (RA) under interstellar conditions. The molecules that have been studied are CH, AlCl, Na+ ... -
Implementation and development of serial synchrotron crystallography at MAX IV
(2023-10-11)Over the past decade, remarkable advancements in femtosecond X-ray free-electron lasers (XFELs) have brought about a profound transformation in structural biology. These XFELs have opened up exciting opportunities for ... -
Microcrystallization and structural studies of proteins by serial crystallography and x-ray scattering
(2023-09-20)Proteins are the most complex and versatile biomolecules known, with essential roles in all cellular and physiological processes. They constitute the main structural components of cells, catalyze most biochemical reactions, ... -
Improving integration efficiency and precision of CRISPR/Cas9-mediated genome editing
(2023-09-07)The clustered regularly interspaced short palindromic repeats (CRISPR) – CRISPR-associated protein 9 (Cas9) system has revolutionized the field of genome engineering, providing a cost-effective and fast tool for targeted ... -
Structural studies of ba3-type cytochrome c oxidase using serial crystallography and X-ray absorption spectroscopy
(2023-08-29)Cytochrome c oxidase (CcO) catalyses the reduction of molecular oxygen to water while the energy released in this process is used transport protons “up-hill” across an energy transducing biological membrane, creating a ... -
Membrane morphology and homeostasis: An electron microscopy approach
(2023-06-26)Biological membranes allow life as we know it to exist. Primarily assembled from lipids and proteins, their morphology and function can greatly vary between species or even within the same cell. They create physical ... -
Revealing functional details of the mitochondrial Lon Protease by NMR spectroscopy
(2023-05-11)Det mänskliga Lon-proteinkomplexet är ett ATP-beroende proteas som finns i den mitokondriella matrisen. Lon-proteinet är en produkt av den kärnkodade genen LONP1 och spelar en avgörande roll i underhåll och reparation ... -
Correlative Chemical Imaging of Nanoscale Subcellular Structures
(2023-05-10)Chemical imaging can elucidate complex mechanisms, relationships, and components of biological samples. For example, it can reveal properties such as chemical composition, chemical structure, reactivity, and topography. ... -
Mapping ultrastructural effects of proteotoxic stress on S. cerevisiae
(2023-05-09)Cells are the basic building blocks of any living being, whether the organism consists of only one, or many cells. The different cellular components interact with one another to maintain the viability of the cell. An ... -
Quantitative NanoSIMS provides subcellular concentration and distribution of oligonucleotide therapeutics
(2023-04-28)Antisense oligonucleotides (ASOs) represent a powerful therapeutic modality that can selectively modulate gene expression. However, ASOs face two major hurdles that restrict their use in the clinic. The first issue is ... -
Multiphoton Microscopy Targeting Tissue Development. Towards the real-time imaging of epidermal differentiation
(2023-04-25)The development of novel organ-on-a-chip models calls for methodologies, which will allow the study of tissue development and pharmacological outcome in real-time. Multiphoton microscopy (MPM) has been proposed as a ...