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Proteostasis and Aging in Saccharomyces cerevisiae - The role of a Peroxiredoxin


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/52316

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Title: Proteostasis and Aging in Saccharomyces cerevisiae - The role of a Peroxiredoxin
Authors: Hanzén, Sarah
E-mail: sarah.hanzen@gu.se
Issue Date: 25-Aug-2017
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry and Molecular Biology ; Institutionen för kemi och molekylärbiologi
Parts of work: I. Lifespan extension and H2O2 resistance elicited by caloric restriction require the peroxiredoxin Tsa1 in Saccharomyces cerevisiae Molin M, Yang J, Hanzén S, Toledano MB, Labarre J, Nyström T Mol Cell (2011) 43:823-33
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II. Lifespan control by redox-dependent recruitment of chaperones to misfolded proteins Hanzén S, Vielfort K, Yang J, Roger F, Andersson V, Zamarbide-Forés S, Andersson R, Malm L, Palais G, Biteau B, Liu B, Toledano MB, Molin M, Nyström T Cell (2016) 166:140-51
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III. Enhancing protein disaggregation restores proteasome activity in aged cells Andersson V, Hanzén S, Liu B, Molin M, Nyström T. Aging (2013) 5:802-12
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Date of Defence: 2017-09-15
Disputation: Fredagen den 15e September, 2017 kl. 09.00 i hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg.
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: Aging
Caloric restriction
Oxidative stress
Peroxiredoxins
Proteostasis
Protein aggregates
Ubiquitin-proteasome system
Abstract: Aging is characterized by a progressive decline in physiological functions that limits biological processes, increases the risk of disease, and ultimately leads to death. At the cellular level, aging is associated with accumulation of damaged components, including proteins, indicating that protein homeostasis (or proteostasis) fails to maintain the integrity and functionality of the proteome as cells age. Reduced caloric intake elevates proteostasis, counteracts the accumulation of damage during... more
ISBN: 978-91-629-0239-1
URI: http://hdl.handle.net/2077/52316
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi

 

 

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