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The role of estrogen and superoxide dismutase in cataractogenesis
(2014-11-03)
Cataract is an opacification of the eye lens, constituting the major cause of blindness globally. Oxidative stress is a key factor in the formation of cataract and female gender is a known risk factor for age-related ...
Paracrine control of glucagon secretion in the pancreatic α-cell: Studies involving optogenetic cell activation
(2020-06-12)
ABSTRACT
The mechanisms controlling glucagon secretion by α-cells in islets of Langerhans
were studied. We generated mice with the light-activated ion channel ChR2
specifically expressed in β-, α-, and δ-cells, and ...
Developing brain and systemic inflammation: a "Toll-like" link with consequences
(2017-05-24)
The developing brain is vulnerable to external insults, and perinatal brain injury (PBI) is a major cause of life-long neurological syndromes such as cerebral palsy. Currently, no pharmaceutical intervention is available. ...
Short- and long-term neuronal plasticity in hippocampal CA1 region of rat
(2010-06-14)
The brain is highly plastic, displaying both short- and long-term changes, resulting from developmental processes as well as learning and memory. Moreover, short-term plasticity such as paired pulse facilitation and ...
Astrocytic communication and cell death during metabolic depression and oxidative stress
(2008-03-19)
Stroke is a major cause of death and adult disability in the western world. Most often, stroke is caused by the occlusion of a brain artery. Within the perfusion territory of the occluded vessel, various degrees of necrotic ...
Autism syndromes in three behavioural phenotype conditions. A clinical psychiatric study of 76 individuals with Möbius sequence, CHARGE syndrome, and oculo-auriculo-vertebral spectrum
(2007-04-12)
AUTISM SYNDROMES IN THREE BEHAVIOURAL PHENOTYPE CONDITIONS
A clinical psychiatric study of 76 individuals with Möbius sequence, CHARGE syndrome, and oculoauriculovertebral spectrum
Maria Johansson
Institute of ...
Preclinical investigations of GlyT-1 inhibition as a new concept for treatment of alcohol dependence
(2011-02-02)
Alcohol addiction and abuse is a main contributor to the global burden of disease and is a high public health priority. Alcohol addiction is a chronically relapsing neurobiological disorder affecting multiple neurotransmitter ...
Mass spectrometry based proteomic strategies applied in the study of central nervous system derived cells
(2007-03-26)
This thesis focuses on evaluation, improvement and development of mass spectrometry based proteomic strategies for identification and quantitation of proteins. Development of such strategies is important to achieve a better ...
Natural course and long-term prognosis in idiopathic Normal Pressure Hydrocephalus - the effect of delayed surgery and clinical factors on outcome and survival
(2020-05-07)
Idiopathic Normal Pressure Hydrocephalus, iNPH, causes gait and balance difficulties, urinary incontinence and cognitive decline in mainly older persons and is treatable by insertion of a cerebrospinal fluid diverting ...
Physical fitness and exercise in adults with congenital heart disease
(2020-04-14)
Background: The population of patients with adult congenital heart disease (ACHD) is growing, and the estimated life expectancy has increased. Therefore, factors related to lifestyle, such as physical activity (PA), exercise, ...