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The role of estrogen and superoxide dismutase in cataractogenesis


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Title: The role of estrogen and superoxide dismutase in cataractogenesis
Authors: Skiljic, Dragana
E-mail: dragana.skiljic@gu.se
Issue Date: 3-Nov-2014
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Clinical Neuroscience and Rehabilitation
Parts of work: I.Celojevic D et al. Effects of 17β-estradiol on proliferation, cell viability and intracellular redox status in native human lens epithelial cells. Molecular Vision. 2011; 17:1987-1996.
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II.Celojevic D et al. Superoxide dismutase gene polymorphisms in patients with age-related cataract. Ophthalmic Genetics. 2013; 34(3):140-145.
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III. Skiljic D et al. Estrogen–related polymorphisms in Estonian patients with age-related cataract. Submitted manuscript, 2014.

IV. Skiljic D et al. Effects of 17β-estradiol on activity, gene and protein expression of superoxide dismutases in human lens epithelial cells. Manuscript.

V. Skiljic D et al. Estradiol levels and superoxide dismutase activity in patients with age-related cataract. Manuscript.
Date of Defence: 2014-11-21
Disputation: Fredagen den 21 november 2014, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: cataract
estrogen
gender
antioixidant enzyme
lens epithelial cells
oxidative stress
polymorphism
superoxide dismutase
Abstract: Cataract is an opacification of the eye lens, constituting the major cause of blindness globally. Oxidative stress is a key factor in the formation of cataract and female gender is a known risk factor for age-related cataract. The aim of this thesis was to investigate the role of estrogen and the antioxidant enzyme superoxide dismutase (SOD) in cataractogenesis. Human lens epithelial cells (HLECs) obtained during cataract surgery at the Department of Ophthalmology at Sahlgrenska university hosp... more
ISBN: 978-91-628-9187-9
URI: http://hdl.handle.net/2077/36756
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

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