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Developing brain and systemic inflammation: a "Toll-like" link with consequences


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Title: Developing brain and systemic inflammation: a "Toll-like" link with consequences
Authors: Mottahedin, Amin
E-mail: amin.mottahedin@neuro.gu.se
Issue Date: 24-May-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Physiology
Parts of work: Stridh L, Mottahedin A, Johansson ME, Valdez RC, Northington F, Wang X, Mallard C. (2013) Toll-like receptor-3 activation increases the vulnerability of the neonatal brain to hypoxia-ischemia. Journal of Neuroscience 2013. 33(29): p. 12041-51.
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Mottahedin A, Svedin P, Nair S, Mohn C-J, Wang X, Hagberg H, Ek J, Mallard C (2017) Systemic activation of Toll-like receptor 2 suppresses mitochondrial respiration and exacerbates hypoxic–ischemic injury in the developing brain. Journal of Cerebral Blood Flow & Metabolism 37:1192-1198.
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Mottahedin A, Smith PL, Hagberg H, Ek CJ, Mallard C (2017) TLR2-mediated leukocyte trafficking to the developing brain. Journal of leukocyte biology 101:297-305.
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Mottahedin A, Ek J, Truvé K, Hagberg H, Mallard C. Differential analysis of TLR2- versus TLR4-induced alterations in transcriptome of choroid plexus reveals leukocyte trafficking mechanisms. Manuscript.

Mottahedin A, Blondel S, Ek J, Babikian A, Hagberg H, Mallard C, Ghersi Egea JF, Strazielle N. N-acetylcysteine inhibits TLR2-mediated neutrophil transmigration through the choroid plexus. Manuscript.
Date of Defence: 2017-06-16
Disputation: Fredagen den 16 juni 2017 kl. 13:00, Sal Ivan Östholm, Medicinaregatan 13, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: developing brain
neonatal brain injury
hypoxia-ischemia
inflammation
infection
Toll-like receptor
choroid plexus
neuroimmunology
Mitochondria
Abstract: The developing brain is vulnerable to external insults, and perinatal brain injury (PBI) is a major cause of life-long neurological syndromes such as cerebral palsy. Currently, no pharmaceutical intervention is available. Hypoxia/ischemia (HI), infections and inflammation are implicated in the pathogenesis of PBI. However, the crosstalk between these etiologies is not fully understood. Toll-like receptors (TLR) 3 and TLR2 are responsible for sensing viral and bacterial infections and initiating ... more
ISBN: 978-91-629-0208-7 (PDF)
978-91-629-0207-0 (Print)
URI: http://hdl.handle.net/2077/51891
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

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