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Paracrine control of glucagon secretion in the pancreatic α-cell: Studies involving optogenetic cell activation


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Title: Paracrine control of glucagon secretion in the pancreatic α-cell: Studies involving optogenetic cell activation
Authors: Miranda, Caroline
E-mail: caroline.miranda@gu.se
Issue Date: 12-Jun-2020
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Physiology
Parts of work: I. Briant, L. Reinbothe, T. Spiliotis, J. Miranda, C. Rodriguez, B. Rorsman, P. δ-cells and β-cells are electrically coupled and regulate α-cell activity via somatostatin. J. Physiol. 2018, Jan 15: 596(2): 197-215
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II. Miranda, C. Kothegala, L. Lundequist, A. G. Belekar, P. Krieger, J-P. Presto, J. Rorsman, P. Gandasi, N.R. Structural correlations influencing regulation of somatostatin-releasing δ-cells (Manuscript)

III. Miranda, C. Tolö, J. Santos, C. Kothegala, L. Mellander, L. Hill, T. Briant, L. Tarasov, A.I. Zhang, Q. Gandasi, N.R. Rorsman, P. Dou, H. Intraislet paracrine crosstalk between islet cells unveiled by optogentic activation of α- and δ-cells. (Manuscript)
Date of Defence: 2020-09-03
Disputation: Torsdagen den 3 september 2020, Kl 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg https://gu-se.zoom.us/j/66671958661?pwd=Qlpka3NKUHVmenJVYnFKemlXMFM3Zz09
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Type 2 Diabetes
Glucagon
α-Cell
Optogenetics
Abstract: ABSTRACT The mechanisms controlling glucagon secretion by α-cells in islets of Langerhans were studied. We generated mice with the light-activated ion channel ChR2 specifically expressed in β-, α-, and δ-cells, and explored the spatio-temporal relationship between cell activation and glucagon release. In paper I, ChR2 was expressed in β-cells and photoactivation of these cells rapidly depolarized neighbouring δ-cell but produced a more delayed effect on α-cells. We showed that these effec... more
ISBN: 978-91-7833-952-5 (PRINT)
978-91-7833-953-2 (PDF)
URI: http://hdl.handle.net/2077/64544
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

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