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Mass spectrometry based proteomic strategies applied in the study of central nervous system derived cells


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Title: Mass spectrometry based proteomic strategies applied in the study of central nervous system derived cells
Authors: Thorsell, Annika
E-mail: annika.dahl@neuro.gu.se
Issue Date: 26-Mar-2007
University: Göteborg University. Sahlgrenska Academy
Institution: Inst of Neuroscience and Physiology. Dept of Psychiatry and Neurochemistry
Parts of work: I. A. Dahl, P. Eriksson, A. Persson, G. Karlsson, P. Davidsson, R. Ekman, A. Westman-Brinkmalm, Proteome analysis of conditioned medium from cultured adult hippocampal progenitors, Rapid Commun Mass Spectrom, (2003) 17:2195-2202
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II. A. Thorsell, J. Faijerson, F. Blomstrand, M. Nilsson, K. Blennow, PS. Eriksson and A. Westman-Brinkmalm, Proteome analysis of serum containing conditioned medium from primary astrocyte cultures, Submitted for publication

III. A. Thorsell, E. Portelius, K. Blennow and A. Westman-Brinkmalm, Evaluation of sample fractionation using micro scale liquid phase iso-electric focusing on mass spectrometric identification and quantitation of proteins in a SILAC experiment, Rapid Commun Mass Spectrom, (2007) 21:771-778
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Disputation: Kommer att offentligen försvaras i psykiatriklinikens aula (V-aula), Sahlgrenska Universitetssjukhuset/Mölndal, Torsdagen den 12 april 2007, kl. 13.00
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: proteomics
mass spectrometry
protein identification
protein quantitation
fractionation
Abstract: This thesis focuses on evaluation, improvement and development of mass spectrometry based proteomic strategies for identification and quantitation of proteins. Development of such strategies is important to achieve a better understanding of regulatory mechanisms of individual cell types, both during normal development and during the onset and progression of diseases. Cells derived from the central nervous system served as model systems. Proteins secreted by these cells can be predicted to be inv... more
ISBN: 978-91-628-7096-6
URI: http://hdl.handle.net/2077/3190
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi
Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

 

 

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