Institute of Neuroscience and Physiology / Inst för neurovetenskap och fysiologi
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Cerebral Venous Thrombosis - Complications and Outcomes
Cerebral venous thrombosis (CVT) is a relatively rare cause of stroke, which predominantly affects working-aged adults and particularly women. The clinical course is highly miscellaneous. Data from large cohorts are scarce ... -
Chronic Achilles Tendon Rupture - Perspectives on outcomes after surgical treatment and rehabilitation
Chronic Achilles tendon rupture (CATR) is a rupture of the Achilles tendon for which adequate diagnosis and treatment has been delayed after index injury. In this thesis defined as 4 weeks or more. The delay is commonly ... -
New Risk Factors in Poststroke Epilepsy
The overall aim of the present research was to identify new risk factors for poststroke epilepsy (PSE). Specifically, we wanted to assess the impact of having a first-degree relative with epilepsy on PSE risk (Paper I), ... -
Cognitive, emotional and psychosocial functions after resective epilepsy surgery
Epilepsy surgery is a potentially curing treatment for a selected group of patients with drug-resistant focal epilepsy. Cognitive side-effects after temporal lobe resections (TLR) are well documented but it is still difficult ... -
Cerebrospinal fluid studies of bipolar disorder
The pathophysiology of bipolar disorder remains to be elucidated. One approach to studying brain processes is analysis of cerebrospinal fluid (CSF). This thesis comprises five studies based on the Sankt Göran Bipolar Project ... -
The Autism - Tics, ADHD and other Comorbidities inventory (A- TAC). Validity, reliability, and the measurement of autism in males and females
The Autism–Tics, ADHD and other Comorbidities inventory (A–TAC) is a broad-band screening instrument for neurodevelopmental disorder (e.g., autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), ... -
Stretch-shortening cycle (SSC) muscle power, muscle strength and functional capacity in Scandinavian women and men - Effects of ageing
Ageing is associated with a gradual decline in physical function due to age-related loss of muscle mass, strength, and muscle power, leading to loss of independence. Physical therapists employ various tests to assess of ... -
On cataract surgery in uveitis - management and outcome in pediatric and adult patients
Aims: To evaluate surgical procedures and outcomes in cataract surgery in adults and children with uveitis. To compare the results of implantation of two different intraocular lenses (IOLs). Methods: Retrospective reviews ... -
Novel cerebrospinal fluid and blood tau biomarkers in Alzheimer's disease and other neurodegenerative diseases
Tau is a protein predominantly expressed in neurons in the central nervous system (CNS), where it binds microtubules (MT), playing a major role regulating their dynamics and architecture. Under pathological conditions, tau ... -
Acute pulmonary embolism - aspects of respiratory symptoms and physical activity
Introduction. Pulmonary embolism (PE) is the third most common cardiovascular disease, after myocardial infarction and stroke. Post-PE syndrome, which is characterized by long-term consequences of PE with persistent dyspnea ... -
Ge alla en chans att vara med - Brukarinvolvering i forskning med och för sköra äldre personer
(2021)Aims: The overall aim with this thesis was to explore how the voices of frail older people can be heard and acknowledged through user involvement in research on aging and health. Two studies are included with the specific ... -
Acquired Epilepsy with a Focus on Stroke: Treatment and Prognosis
(2022-02-23)The relationship between epilepsy and stroke is complicated. While stroke is a major cause of epilepsy after middle age, there is also evidence that the risk of stroke is increased in persons with epilepsy. The overall aim ... -
Blood Vessels, Biomarkers, and Broken Barriers: lnvestigations of the Brain Vasculature in Models of Neonatal Brain lnjuries
(2022-02-10)Brain injury during the perinatal period can lead to lifelong impairment in cognitive and motor function, or an early death. Term neonatal encephalopathy and preterm germinal matrix haemorrhage are two conditions that can ... -
Human iPSC-derived neuronal networks. Development and application for compound evaluation
(2022-02-03)Research on human brain development and function in health and disease has been hampered by limited access to primary human tissue and limited translatability of animal studies. This knowledge gap is encouraging the use ... -
The role of the alpha 7 nicotinic acetylcholine receptor in inflammation and brain injury
(2022-01-13)The alpha 7 nicotinic acetylcholine receptors (α7nAChR) are expressed in the nervous system as well as on peripheral immune cells where it participates in the cholinergic anti-inflammatory pathway. Inflammation is a common ... -
Atrial fibrillation in aging; methodological aspects and the relation to dementia and cerebral vascular disease
(2022-01-12)Emerging evidence suggest an increased risk of dementia in individuals with atrial fibrillation (AF). However, until recently, few studies have investigated the relation between AF and dementia taking both prevalent and ... -
lnternalizing problems in childhood and adolescence: predictive, etiological, and neurodevelopmental aspects
(2021-11-25)Internalizing disorders such as anxiety and depressive disorders are common mental disorders in childhood and adolescence. They are characterized by disordered emotions and moods, causing emotional distress and impairment. ... -
Word-finding difficulties in left hemisphere stroke, multiple sclerosis and Parkinson's disease - differences in symptom occurrence and effects of anomia treatment
(2021-11-11)Word-finding difficulties, or anomia, are a common symptom in various conditions affecting the brain, such as stroke, multiple sclerosis (MS) or Parkinson’s disease (PD). The aim of this thesis is twofold: (i) to increase ... -
Physiological roles of amyloid precursor protein in vivo - zebrafish as a model
(2021-10-26)Amyloid-beta precursor protein (APP) is an evolutionarily conserved transmembrane protein expressed in many different tissues. APP belongs to a gene family consisting of two other APP-like proteins (APLP1 and APLP2). APP ... -
Cognition and activity early after stroke
(2021-10-13)Introduction and aims: Cognitive impairment and dependency in activities of daily living (ADL) are common consequences of stroke. Due to a decrease in the length of hospital stay, assessment of these conditions ...
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