Institute of Neuroscience and Physiology / Inst för neurovetenskap och fysiologi
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Health conditions, functioning and social outcomes in adults with cerebral palsy
(2024-02-21)Background: A majority of individuals with cerebral palsy (CP) are adults, and yet healthcare and research are focused on children. In comparison to the consequences in childhood, little is known about the long-term ... -
A treatment seeking population with Gambling Disorder - Internet treatment, severity and gender
(2024-02-21)Gambling is a common pastime all over the world, but can become harmful in excess and can even develop into an addictive behavior, a Gambling Disorder (GD). The aim of this thesis was to contribute to the clinical understanding ... -
Regulation of amyloid beta generation and its involvement in synaptic function: studies in human iPSC-derived cortical neurons
(2024-02-21)Alzheimer’s disease (AD) is a neurodegenerative disease that affects millions of individuals worldwide and exerts a profound societal and economic impact. Clinically characterized by a gradual loss of memory, cognitive and ... -
Labile glutamate synaptic transmission onto CA1 hippocampal pyramidal neurons: regional, functional and developmental diversity
(2024-02-14)A single neuron in the brain receives tens of thousands of glutamate synapses from other neurons, and these synapses can differ in their properties depending on their role in the neural circuit, during brain development ... -
Outcome after treatment of cerebral aneurysms
(2024-02-08)A cerebral aneurysm is a saccular or tubular-like deformity of the arterial vessel wall which is usually thinner. The rupture of a cerebral aneurysm is associated with a high morbidity and mortality by causing an aneurysmal ... -
Speech production and literacy in students with intellectual disabilities and communication difficulties
(2024-02-07)Many individuals with intellectual disabilities have difficulties with spoken communication and literacy learning leading to vulnerability. It has been suggested that interventions to promote reading in this group not only ... -
Pregnancy-related pelvic girdle pain management. Tailored physiotherapy treatment strategies anchored in women's experiences and expectations
(2024-01-11)Introduction: Pregnancy-related pelvic pain (PGP) affects over half of all pregnant women. This pain can significantly impact daily activities and limit the ability to move freely, leading to reduced physical activity, ... -
Children who screen positive for language delay but not autism: from 2.5 to 6 years of age
(2023-12-05)Background: Language disorders (LDs) are prevalent, affecting approximately 10% of children. Among them, 7.5% have developmental language disorder (DLD), while 2.5% have LD associated with a known medical condition. In ... -
The AfterBabyBodyStudy: Muscular changes, exercising, and activity limitations and their associations with pelvic girdle pain and urinary incontinence in the postpartum period
(2023-11-21)Aim: Pregnancy and childbirth can lead to several symptoms, changes in the pelvic floor muscles and a diastasis recti abdominis (DRA). This thesis aimed to assess and explore stress urinary incontinence, vaginal heaviness, ... -
Sex differences in behavior and metabolism
(2023-11-16)Men and women exhibit distinct illness patterns and disparate responses to pharmacotherapies. However, there is a scarcity of preclinical studies that systematically compare the sexes. The overarching aim of this thesis ... -
Physical activity and stroke - Associations and patient experiences
(2023-11-15)Background: Insufficient physical activity is a global problem and a risk factor for stroke. Furthermore, physical activity is often reduced after stroke, and many patients are physically inactive in stroke units. Aim: ... -
Pharmacokinetics and pharmacodynamics of the psychedelic compound DMT
(2023-11-15)N,N-dimethyltryptamine (DMT) is a psychedelic compound that is being investigated as a treatment option in depression. It is also being used as a research tool in research aiming to investigate the neurobiology of the ... -
Young Children with Autism in a Multiethnic Immigrant Population. Prevalence, Feeding Disorders, Early Detection, and Intervention
(2023-11-14)Background: Autism is a neurodevelopmental condition characterized by a pattern of major impairments in social communication and behavioural/sensory problems, with high rates of coexisting neurodevelopmental and medical ... -
On the Surgical Management of Diffuse Low-Grade Gliomas in Adults
(2023-11-10)Diffuse low-grade gliomas (dLGG) are rare, slow-growing, yet difficult-to-treat brain tumors that typically affect young to middle-aged adults. The aim of the thesis has been to identify factors affecting management and ... -
Physiology and Pathophysiology of Hormone Secretion from lslets of Langerhans
(2023-10-30)Diabetes is a metabolic disorder stemming from the improper regulation of blood glucose levels by hormones secreted by pancreatic islets of Langerhans. Paper I describes the mechanism by which glucose can regulate glucagon ... -
Executive functions and ERP Biomarkers in children and adolescents with ADHD and Autism
(2023-10-19)Executive Functions (EF) refers to skills that help us initiate, organize and evaluate activities. Problems with EF are associated with neurodevelopmental disorders such as Attention Deficit Hyperactivity Disorder (ADHD) ... -
Hearing in advanced age Epidemiological, pathophysiological, and diagnostic perspectives from the Gothenburg H70 Birth Cohort Studies
(2023-10-16)The population aged 80 and above is expected to increase in the future resulting in an anticipated rise in health care demands. Age-related hearing loss (ARHL) is described as the third most common health condition ... -
Amyloid Maturation Patterns in Alzheimer's Disease - Novel chemical imaging of Aβ and Tau pathology
(2023-10-11)Alzheimer’s disease (AD) accounts for approximately 70% of dementia cases in Sweden. It can be of genetic origin i.e. familial form (fAD), sporadic form (sAD). AD is characterized by the deposition of amyloid and tau ... -
Upper extremity functioning in individuals with cervical or thoracic spinal cord injury - From body functions to participation
(2023-09-28)Background: A spinal cord injury (SCI) can lead to a range of impairments in various body functions, including the function of upper extremity, with severity varying from mild to severe. Long-term consequences for functioning ... -
Suicidality and depression in older adults: Prevalence, predictors, and outcomes
(2023-09-08)Older adults have the highest risk of suicide of all age groups. Depression is a major risk factor for suicide in late life, but is also associated with lower quality of life, somatic disorders, and premature death. The ...