Institute of Neuroscience and Physiology / Inst för neurovetenskap och fysiologi
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Correlative Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease
(2024-12-11)The formation of beta-amyloid (Aβ) plaques and neurofibrillary tangles are key pathological hall-marks of Alzheimer’s disease (AD), where amyloid has been identified to precede and even initiate other neurodegenerative ... -
Adult psychiatric outpatients; neuropsychiatric, neuropsychological and neurodevelopmental aspects
(2024-12-05)ABSTRACT Background: Neurodevelopmental disorders - including autism and attention- deficit/hyperactivity (ADHD) - are relatively common in the general population with a total prevalence rate of at least 10%. Most research ... -
Nanoelectrochemical analysis of neurotransmitter release in cell models of Alzheimer's disease
(2024-12-04)Neurotransmitter release and binding to receptors are tightly regulated, and aberrant changes can cause neuropsychiatric and neurodegenerative disorders. Alzheimer's disease (AD) is a complex, age-related neurodegenerative ... -
Diagnostic imaging and functional outcome in patients with diffuse glioma grades 2 and 3. From presentation to the 12-month post-operative follow-up
(2024-12-04)The overall aim of this thesis was to contribute to the improvement of diagnostic imaging and functional outcome practices in adult patients with diffuse glioma grades 2 or 3. At the preoperative stage our studies assessed ... -
Team-based rehabilitation in primary care for patients with musculoskeletal disorders Experiences, effect- and process evaluation
(2024-11-20)Most people will experience musculoskeletal disorders at some point in their lives, ranging from a manageable problem to significant difficulties with mobility, sleeping, performing daily activities, and working. There is ... -
Exploring pain, fatigue and physical activity in adolescents with Hypermobility Spectrum Disorder or hypermobile Ehlers-Danlos Syndrome
(2024-11-19)Adolescents with Hypermobility Spectrum Disorder (HSD) and hypermobile Ehlers–Danlos Syndrome (hEDS) — two overlapping hereditary connective-tissue disorders characterized by joint hypermobility, chronic pain, impaired ... -
Novel biomarkers for parkinsonian disorders
(2024-11-12)Parkinsonian disorders (PS) are a heterogeneous group of neurodegenerative diseases characterised by the presence of parkinsonism. Parkinson’s disease (PD) is the most common PS, characterised by the accumulation of ... -
Endocrine and neural mechanisms in metabolic control
(2024-11-11)The regulation of eating behavior and metabolism is governed by complex inter-actions between central and peripheral signals, with hormones such as oxytocin (OT) and glucagon-like peptide-1 (GLP-1) playing pivotal roles. ... -
The alpha 7 nicotinic acetylcholine receptor in cardiovascular disease
(2024-09-26)The alpha 7 acetylcholine nicotinic receptors (α7nAChRs) are expressed on human leukocytes and regulate inflammation. Consequently, the α7nAChRs are potential pharmacological targets for several inflammatory diseases. ... -
Social and motor coordination: methods development and applications in ESSENCE
(2024-09-24)This thesis aimed to develop and apply methods for evaluating social and motor coordination, domains that often are challenged in individuals with neurodevelopmental/neuropsychiatric disorders (NDDs), also referred within ... -
Survival of patients with glioblastoma - advancements in the past two decades
(2024-09-24)Background: Glioblastoma is the most common and most aggressive form of primary malignant brain tumors in adults. The prognosis is generally poor, with a median survival of around 15-16 months, even with aggressive multimodal ... -
Thoracic Mobility in Cystic Fibrosis Care
(2024-08-19)Introduction: Cystic fibrosis (CF) is an incurable and highly life-limiting hereditary disease. However, due to significant medical advancements over recent decades, life expectancy has risen to close to 50 years. As such, ... -
Physical Activity Before and After Stroke - Examining Stroke lncidence and Outcomes
(2024-05-24)Background: Stroke is a leading cause of death and disability worldwide. A physically active lifestyle may prevent stroke and decrease the consequences of a stroke. Physical activity is also an important component in ... -
Ge de ohörda rösterna upprättelse - framsteg och utmaningar vid involvering av sköra äldre personer i forskning om åldrande och hälsa
(2024-05-16)Introduktion: I Sverige och globalt har vi en demografisk utveckling med en allt större del åldrad befolkning. Forskning om åldrande och hälsa har därför en allt viktigare roll i samhället. Samtidigt är det just nu en ... -
Meningiomas - consequences of incidental detection and novel classification
(2024-05-06)Aim Meningiomas are often benign, slow-growing tumors found in older individuals. This thesis aimed to examine the occurrence of incidental meningioma, the surgical and quality of life outcomes after surgery and to evaluate ... -
Visual function and functional vision – ophthalmological perspectives on a normal population
(2024-05-03)Aim: The aim was to investigate visual function and functional vision in 70-year-olds in Gothenburg Sweden. Methods: A group 1203 randomized 70-year-olds completed questionnaires on somatic, social health, and well-being. ... -
Cholinergic modulation of dopamine-related effects of ethanol in the rat
(2024-04-25)Alcohol use disorder is associated with serious medical consequences leading to preterm death. Alcohol activates the brain reward system, leading to an increase of extracellular dopamine (DA) levels in the nucleus accumbens ... -
Psychological outcomes during rehabilitation after ACL reconstruction - and implications for second ACL injury
(2024-04-24)An anterior cruciate ligament (ACL) injury is a common knee joint injury. An ACL injury is typically managed through surgical reconstruction of the ligament, followed by rehabilitation. For patients treated with ... -
Predictors of severe kidney disease in long-term lithium treatment
(2024-04-22)The thesis aims to advance the understanding of severe chronic kidney disease in lithium-treated patients through four observational studies in which subjects were recruited from the Sahlgrenska University Hospital laboratory ... -
Physiotherapist as primary assessor of knee osteoarthritis in primary care - Evaluation of patients’ self-assessment, preferences, quality of life, and health economy
(2024-03-27)Aim: The purposes with this thesis was to evaluate the feasibility of 30-second chair stand test as a self-test, and to investigate the effects of direct access to physiotherapist on costs and health in people with knee ...
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