Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi by Title
Now showing items 163-182 of 191
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Structural studies of aquporins in human kidney and plant
(2013-03-22)Membrane proteins are key players in our biology and are links between the inside and the outside of the cell, allowing for signal transduction and transport of molecules. Aquaporins are membrane protein channels that allow ... -
Structural studies of ba3-type cytochrome c oxidase using serial crystallography and X-ray absorption spectroscopy
(2023-08-29)Cytochrome c oxidase (CcO) catalyses the reduction of molecular oxygen to water while the energy released in this process is used transport protons “up-hill” across an energy transducing biological membrane, creating a ... -
Structure-based drug design applied to the antibacterial target MraY
(2019-12-10)Antibiotic resistance is one of the biggest threats to human health of our time. We are being warned of a so-called post-antibiotic era, where a simple surgery or bacterial infection could kill human beings. Without the ... -
Symmetry of Halonium Complexes in Solution
(2012-01-13)In this thesis the symmetry of two interaction types involving electropositive halogens have been studied in solution; the N-X+-N halogen bond (X = Br or I), and the C-X+-C interaction of previously characterised, cyclic, ... -
Synthesis, Pharmacological Characterization and QSAR Modelling of 4-Phenylpiperidines and 4-Phenylpiperazines Effects on the dopaminergic neurotransmission in vivo
(2012-11-19)The endogenous neurotransmitter dopamine (DA) is involved in several functions that are controlled from the central nervous system (CNS), for example behaviour, memory, cognition and reward. A disturbed dopaminergic ... -
Systems-level investigation of the interaction between glucose metabolism and the Snf1/Mig1 signalling pathway
(2016-11-21)Saccharomyces cerevisiae Snf1 and its mammalian homolog, AMPK, are members of a protein kinase family present throughout the Eukaryotic kingdom. AMPK plays an essential role in different cellular processes and is involved ... -
A Tale of Chaos and Colour Influencing the photophysical properties and glass forming abilities of BODIPY dyes via structural modification
(2023-04-04)Organic dyes are everyday contributors in chemistry, physics and biology. BODIPY dyes were used as model dye class in this thesis. They are well-known for their versatility, which mainly originates from the tuneability ... -
Terahertz radiation as a pump and probe for studying low frequency vibrations in proteins
(2015-09-18)Many functionally important structural changes in proteins proceed along the direction of their lowest frequency vibrations. These vibrations correspond to picosecond collective dynamics. Establishing the fundamental ... -
The Extended Role of the Molecular Chaperone CCT
(2016-03-23)The oligomeric chaperone CCT is a large ATP-dependent chaperonin that consists of two rings placed back-to-back with eight different paralogous subunits with a size of ~ 55 kDa that sit in each of the two rings. The ... -
The Foxf2 gene in development and disease
(2015-10-29)The Foxf2 gene in development and disease Azadeh Reyahi Department of Chemistry and Molecular Biology, University of Gothenburg, Box 462, SE 405 30, Göteborg, Sweden Abstract In this thesis I present our recent data ... -
The Marine Carbonate System: Ionic Interactions and Biogeochemical Processes
(2014-05-07)The absorption of atmospheric carbon dioxide (CO2) by seawater and subsequent equilibrium reactions within this ionic medium give rise to a complex chemical system often referred to as the marine carbonate system. This ... -
The Mechanisms of Exocytosis Studied in Cells and Models with Amperometry
(2013-05-15)Exocytosis is the universal basis for neuronal communication, allowing the controlled release of neurotransmitter molecules from the presynaptic cell. Exocytosis has been widely studied in many systems. However, the details ... -
The molecular chaperone CCT: Functions beyond folding
(2021-10-07)The chaperonin-containing tailless complex polypeptide 1 (CCT) is a eukaryotic ~1 MDa barrel shaped molecular chaperone, built up by eight distinct subunits and is required for the folding of the abundant cytoskeletal ... -
The Primary Structural Photo-Response of a Bacterial Phytochrome Probed by Serial Femtosecond Crystallography
(2020-04-14)Species across all kingdoms of life rely on the ability to sense different light conditions. Some organisms convert light into chemical energy via the reactions involved in photosynthesis, whereas others use it to trigger ... -
The solution conformations of macrocycles. Applications in the exploration of weak interactions and in drug development
(2017-09-26)Understanding the solution conformation and dynamics of molecules with biological relevance, as well as the impact of their conformation stabilizing weak interactions, is for example important for drug design. Macrocycles ... -
The Structural Modularity and Inherent Dynamics of the DegP Protease together with its Intertwined Role in the Bacterial Periplasm
(2021-12-09)The protein quality control machinery is a delicate and integrated network of molecular tools working together to fold or remove unwanted proteins from the cell. A distinct set of “gatekeepers” are involved in this process ... -
The Synthesis and Use of Certain Pyridine Derivatives as Modulators of the G-protein Coupled Receptors mGlu5 and P2Y12
(2012-11-20)The glutamatergic mGlu5 receptor and the purinergic P2Y12 receptor are two important targets in the development of novel treatments of gastroesophageal reflux disease (GERD) and thrombosis, respectively. Synthesis was ... -
Time Resolved Diffraction Studies of Structural Changes in Sensory Rhodopsin
(2019-11-29)Responding to different light conditions is an essential process for many organisms on earth. Unicellular organisms are no exception to this and mechanisms for controlling cellular movement must often be sensitive ... -
Time-resolved X-ray diffraction and solution scattering studies of Sensory Rhodopsin II in isolation and in complex with its transducer
(2022-05-30)Light is an important source of energy for many living organisms. Many life forms have therefore evolved cellular receptors that are able to sense light and thereby optimise conditions for photosynthesis and pho- totrophy. ... -
Towards 3D Covalent Organic Framework Films
(2022-05-03)Porous materials are of great scientific interest because they are able to interact with guests, such as ions, atoms and molecules throughout their entire volume. One big subgroup of organic porous materials are covalent ...