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The Extended Role of the Molecular Chaperone CCT


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/41921

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Title: The Extended Role of the Molecular Chaperone CCT
Authors: Svanström, Andreas
E-mail: andreas.svanstroem@gmail.com
Issue Date: 23-Mar-2016
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry and Molecular Biology ; Institutionen för kemi och molekylärbiologi
Parts of work: I. Spiess M. et al. Over-Expression Analysis of All Eight Subunits of the Molecular Chaperone CCT in Mammalian Cells Reveals a Novel Function for CCTdelta. J Mol Biol. 2015; 427(17): 2757-64.
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II. Elliott K.L. et al. A novel function of the monomeric CCTepsilon subunit connects the serum response factor pathway to chaperone-mediated actin folding. Mol Biol Cell. 2015; 26(15): 2801-9.
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III. Svanström A. and J. Grantham. The molecular chaperone CCT modulates the activity of the actin filament severing and capping protein gelsolin in vitro. Cell Stress Chaperones. 2015; 21(1): 55-62.
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Date of Defence: 2016-04-28
Disputation: Torsdagen den 28:e april 2016, kl. 10.00, Hörsal Carl Kylberg, Medicinaregatan 7
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: CCT oligomer
Actin
CCT delta
CCT epsilon
Gelsolin
MRTF-A
Cell morphology
Abstract: The oligomeric chaperone CCT is a large ATP-dependent chaperonin that consists of two rings placed back-to-back with eight different paralogous subunits with a size of ~ 55 kDa that sit in each of the two rings. The function of CCT is mainly to fold the abundant proteins actin and tubulin, components of the cytoskeleton. However, several studies have shown that CCT has a wide diversity of low-abundant substrates. In addition, CCT and monomeric subunits of CCT have been shown to influence cyto... more
ISBN: 978-91-628-9748-2 (PDF)
978-91-628-9749-9 (Print)
URI: http://hdl.handle.net/2077/41921
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi

 

 

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