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The solution conformations of macrocycles. Applications in the exploration of weak interactions and in drug development


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Title: The solution conformations of macrocycles. Applications in the exploration of weak interactions and in drug development
Authors: Danelius, Emma
E-mail: emma.danelius@chem.gu.se
emma.danelius@gmail.com
Issue Date: 26-Sep-2017
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry and Molecular Biology ; Institutionen för kemi och molekylärbiologi
Parts of work: Insight into β-Hairpin Stability: Interstrand Hydrogen Bonding Emma Danelius, Ulrika Brath, Máté Erdélyi Synlett, 2013, 24, 2407–2410
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Assessing the Ability of Spectroscopic Methods to Determine the Difference in the Folding Propensities of Highly Similar β- Hairpins Hanna Andersson, Emma Danelius, Patrik Jarvoll, Stephan Niebling, Ashley J. Hughes, Sebastian Westenhoff, Ulrika Brath, Máté Erdélyi ACS Omega, 2017, 2, 508–516
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Halogen Bonding: a Powerful Tool for Modulation of Peptide Conformation Emma Danelius, Hanna Andersson, Patrik Jarvoll, Kajsa Lood, Jürgen Gräfenstein, Máté Erdélyi Biochemistry, 2017, 56, 3265–3272
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Flexibility is Important for Inhibition of the MDM2/p53 Protein−Protein Interaction by Cyclic β-Hairpins Emma Danelius, Mariell Pettersson, Matilda Bred, Jaeki Min, M. Brett Waddell, R. Kiplin Guy, Morten Grøtli, Máté Erdélyi Organic and Biomolecular Chemistry, 2016, 14, 10386–10393
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Conformational Preferences of Macrocyclic Azapeptide Inhibitors of CD36 in Aqueous Solution Emma Danelius, Ahsanullah Ahsanullah, Máté Erdélyi, William Lubell Manuscript
Date of Defence: 2017-10-20
Disputation: Fredagen den 20 oktober 2017 kl 09:15, KC Kemihuset Chalmers, Kemigården 4, Göteborg
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: Kemi
Organisk kemi
Abstract: Understanding the solution conformation and dynamics of molecules with biological relevance, as well as the impact of their conformation stabilizing weak interactions, is for example important for drug design. Macrocycles have attractive pharmaceutical properties, and are of special interest as drug leads for targets with large, flat and featureless binding sites like protein-protein interfaces. As they are usually flexible and adopt a variety of solution geometries, the description of their ens... more
ISBN: 978-91-629-0274-2
978-91-629-0275-9
URI: http://hdl.handle.net/2077/52335
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi

 

 

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