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The molecular chaperone CCT: Functions beyond folding

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Title: The molecular chaperone CCT: Functions beyond folding
Authors: Vallin, Josefine
Issue Date: 7-Oct-2021
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry and Molecular Biology ; Institutionen för kemi och molekylärbiologi
Parts of work: I: Interactions between monomeric CCTδ and p150Glued: A novel function for CCTδ at the cell periphery distinct from the protein folding activity of the molecular chaperone CCT (2018) Echbarthi M., Vallin J., Grantham J. Experimental Cell Research 370: 137–149. DOI:

II: Correlated fluorescence microscopy and multi-ion beam secondary ion mass spectrometry imaging reveals phosphatidylethanolamine increase in the membrane of cancer cells over-expressing the molecular chaperone subunit CCTδ. (2021) Fletcher J.S., Sämfors S., Vallin J., Svanström A., Grantham J. Analytical and Bioanalytical Chemistry 413:445–453, DOI:

III: Functional assessment of the V390F mutation in the CCTδ subunit of chaperonin containing tailless complex polypeptide 1. Vallin J., Grantham J. Cell stress chaperones In Press

IV: Sequestration of the Transcription Factor STAT3 by the Molecular Chaperone CCT: A Potential Mechanism for Modulation of STAT3 Phosphorylation. (2021) Vallin J., Córdoba-Beldad C.M., Grantham J. Journal of Molecular Biology (2021) 433, 166958. DOI:

V: The molecular chaperone CCT sequesters gelsolin and protects it from cleavage by caspase-3 Cuellar J., Vallin J., Svanström A., Maestro M., Bueno-Carrasco M.T., Willardson B.M., Valpuesta J.M., Grantham J. Manuscript
Date of Defence: 2021-10-29
Disputation: Fredagen den 29 oktober 2021 kl. 12.30, 2119, Hus 2 HVB, Institutionen för vårdvetenskap och hälsa, Arvid Wallgrens backe, ingång F
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: TRiC
CCT oligomer
CCT monomer
Abstract: The chaperonin-containing tailless complex polypeptide 1 (CCT) is a eukaryotic ~1 MDa barrel shaped molecular chaperone, built up by eight distinct subunits and is required for the folding of the abundant cytoskeletal proteins actin and tubulin. CCT exists as an assembled oligomer, micro-complexes and as individual subunits in the cell. In addition to folding, CCT is connected to a variety of cellular processes that involve both assembled CCT oligomer and individual monomeric CCT subunits. Monom... more
ISBN: 978-91-8009-502-0
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi



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