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Synthesis, Pharmacological Characterization and QSAR Modelling of 4-Phenylpiperidines and 4-Phenylpiperazines Effects on the dopaminergic neurotransmission in vivo


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/31366

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Title: Synthesis, Pharmacological Characterization and QSAR Modelling of 4-Phenylpiperidines and 4-Phenylpiperazines Effects on the dopaminergic neurotransmission in vivo
Authors: Pettersson, Fredrik
E-mail: fredrik_pettersson@mail.se
Issue Date: 19-Nov-2012
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry ; Institutionen för kemi
Parts of work: I. Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (Huntexil, Pridopidine, ACR16). Pettersson F, Pontén H, Waters N, Waters S, Sonesson C.
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II. Synthesis and Evaluation of a Set of para-Substituted 4-Phenylpiperidines and 4-Phenylpiperazines as MAO Inhibitors. Pettersson F, Svensson P, Waters N, Waters S, Sonesson C.
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III. Synthesis, Pharmacological Evaluation and QSAR Modeling of mono-Substituted 4-Phenylpiperidines and 4-Phenylpiperazines Fredrik Pettersson, Peder Svensson, Susanna Waters, Nicholas Waters, and Clas Sonesson

IV. New quantum mechanically derived electronic principal properties of aromatic substituents. Ylva Sunessona, Per-Ola Norrby, Fredrik Pettersson, Clas Sonesson and Peder Svensson
Date of Defence: 2012-12-07
Disputation: Fredagen den 7:e December 2012, kl. 09.30 i sal KA, Kemihuset Chalmers
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: dopamine
D2
monoamine oxidase
DOPAC
in vivo
QSAR
dopaminergic stabilizer
Abstract: The endogenous neurotransmitter dopamine (DA) is involved in several functions that are controlled from the central nervous system (CNS), for example behaviour, memory, cognition and reward. A disturbed dopaminergic neurotransmission may lead to many severe conditions, such as schizophrenia, attention deficit hyperactivity disorder (ADHD) or Parkinson's disease (PD). The dopamine receptors belong to the G-protein coupled receptors (GPCRs) and are divided into five distinct subtypes (D1-D5). Thes... more
ISBN: 978-91-628-8588-5
URI: http://hdl.handle.net/2077/31366
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi

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