Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för medicin by Title
Now showing items 21-40 of 609
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Androgen receptor signaling mechanisms in bone
(2018-12-13)Osteoporosis is a common age-related disease that increases the risk of fractures. Androgens are crucial for bone health in males. Although a substantial part of the effects of androgens on the skeleton is mediated via ... -
Androgens and progesterone in tissues and the gastrointestinal tract - Mapping of tissue-specific sex steroid levels in mice
(2023-10-16)Sex steroids such as androgens can exert both positive and negative effects in tissues and are important in physiology and pathophysiological states of men and women. Androgens originate mainly from the gonads. Local ... -
THE ANGIOGENIC RESPONSE IN HYPOXIC HEART. Experimental studies in mice.
(2009-01-14)Coronary artery disease is the leading cause of death in the western world today. Although induction of angiogenesis would appear to be an ideal therapeutic strategy, clinical trials of proangiogenic factors have proved ... -
Antimicrobial peptides in the treatment of infectious and inflammatory conditions - Preclinical studies of mechanism of action, efficacy, and safety
(2016-10-20)The rapid emergence of antibiotic-resistant microbes worldwide and the urgent need of new antimicrobial agents have stimulated interest in antimicrobial peptides (AMPs) as new therapeutics for treatment of infectious ... -
Aortic valve surgery: Clinical studies after autograft, homograft and prosthetic valve replacement
(2010-11-19)Aortic Valve Surgery Clinical studies after autograft, homograft and prosthetic valve replacement Obaid Aljassim, MD Department of Cardiovascular Surgery and Anaesthesia, Sahlgrenska University Hospital and University ... -
Aplastic anemia - a population-based study of epidemiology, treatment, and prognostic factors
(2020-09-03)Background and aims. Aplastic anemia (AA) is a rare but life-threatening disease. The introduction of immunosuppressive treatment (IST) and hematopoietic stem cell transplantation (HSCT) has considerably improved the outcome ... -
Approaches to ensure and improve quality at primary healthcare centres - a study of the effects of a structured patient-sorting system and a healthcare reform
(2015-01-09)Background: Primary healthcare in Sweden meets increased demands from an aging population concerning quality and accessibility while dealing with a growing shortage of general practitioners and imperfect efficiency. ... -
Arthritis and immune-mediated bone loss - role of estrogen signalling pathways
(2012-12-13)Objective: Rheumatoid arthritis (RA) is associated with immune-mediated bone loss and thereby increased risk for fractures. Estrogen and selective estrogen receptor modulators (SERMs) ameliorate not only the incidence and ... -
Aspects of Abnormal Glucose Regulation in Various Manifestations of Coronary Artery Disease
(2012-02-03)Background Diabetes is common among patients with coronary artery disease (CAD) and is associated with an approximate doubling of the mortality risk in this patient population. Prediabetes, an intermediate glycometabolic ... -
Aspects of cardiac arrest in Sweden - studies based on the Swedish Registry for CPR
(2023-03-22)Background: Since the introduction of modern cardiopulmonary resuscitation (CPR) by Peter Safar in the late 1950s, a tremendous amount of work and scientific discovery has expanded our knowledge of cardiac arrest (CA), ... -
Aspects of cost-effectiveness and feasibility of implementations for care of depressed persons in primary care - internet-based treatment and care manager organisation
(2019-01-18)Background: Depression is a major source of human suffering and a growing challenge for societies worldwide. The lion’s share of depressed persons in Sweden are diagnosed and treated in primary care. There is an urgent ... -
Aspects of diagnosis and treatment of hypopituitarism in adult life
(2009-02-27)Management of adult patients with hypopituitarism can improve with better char¬ac¬terisation of idiopathic pituitary insufficiency (IPI) and clearer diagnosis of central hy¬pothy¬roidism (CH). Moreover, optimised treatment ... -
Aspects of fracture prevention - The role of fracture liaison services and alendronate
(2020-11-05)Objective: In an ageing population, osteoporotic fractures become more common and cause increased morbidity, mortality and societal cost. This thesis aimed to determine the potential role of fracture liaison services (FLS) ... -
Aspects of heart failure development and prevention in women
(2020-04-15)Heart failure (HF) is a severe progressive condition. Women more often are older and suffer from heart failure with preserved ejection fraction (HFpEF), contrasting to men who more often are younger and suffer from heart ... -
Aspects of Intraoperative Ablation for Atrial Fibrillation
(2009-08-28)Background: Increasing knowledge about mechanisms that trigger and maintain atrial fibrillation (AF) has influenced the possibilities for treatment and even cure of AF. The surgical Cox Maze III procedure is still the gold ... -
Aspects of management of depression in primary care
(2017-03-03)Aim: The general aim of this thesis was to evaluate effects of recurrent use of a self-assessment instrument in general practitioner (GP) consultations with the patient with depression in the primary care clinical context. ... -
Aspects of Plasminiogen Activator Inhibitor 1 in Metabolic Syndrome
(2016-05-31)Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of the fibrinolytic system and binds irreversibly to tissue-type plasminogen activator (t-PA), and thereby inhibits the protective action of t-PA against ... -
Aspects of validity in stress research
(2015-11-05)Aim: To increase knowledge about validity evaluation and interpretability of a multi-item self-report questionnaire used in occupational health and stress research, and to investigate longitudinal associations between the ... -
Aspects of work and health in women with fibromyalgia
(2015-03-13)Fibromyalgia (FM) is characterized by persistent widespread pain, increased pain sensitivity and tenderness. FM is also associated with fatigue, psychological distress, impaired physical capacity, activity limitations and ... -
Aspects on long-term treatment with tyrosine kinase inhibitors in Chronic myeloid leukemia
(2011-11-18)Chronic myeloid leukemia (CML) is caused by the tyrosine kinase activity of the oncoprotein BCR-ABL. The introduction of tyrosine kinase inhibitors (TKIs) targeting BCR-ABL has profoundly changed the prognosis of CML. ...