Institute of Medicine / Institutionen för medicin
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Exploring small airways using breath analyses
Background: Airway irritants such as allergens, tobacco smoke and viruses may cause damage in the small airways, usually undetected with routine diagnostic methods. Analyses of endogenously produced nitric oxide (NO) and ... -
Occupational heat exposure and kidney disease - Studies on the role of heat stress in the Mesoamerican epidemic of Chronic Kidney Disease of non-traditional origin
This thesis examines the association between heat stress and kidney disease in Mesoamerica using different perspectives and methods. An ecologic study found that hot, sugarcane-cultivating regions had elevated chronic ... -
Nutritional impact on health in patients with Rheumatoid Arthritis
Objective: Rheumatoid Arthritis (RA) is the most common autoimmune rheumatic disease, affecting around 0.5-1% of the population. The aim of this thesis was to study dietary impact on markers of health in patients with ... -
Allergic and non-allergic asthma: Translational research in immunology
Asthma is a chronic heterogeneous respiratory disease affecting more than 300 million people globally. The different phenotypes, including allergic and nonallergic asthma, are driven by different underlying mechanisms ... -
Defining the clinical usefulness of vertebral fracture assessment
Objective: Vertebral fractures (VFs) are the most common osteoporotic fracture and among the strongest predictors for future fracture. VFs can be identified by vertebral fracture assessment (VFA) from lateral spine imaging ... -
Acromegaly - Mortality, Morbidity and Treatment Patterns
Background: Acromegaly is a systemic disease associated with multiple comorbidities. The clinical characteristics of acromegaly develop insidiously over several years and the diagnosis is usually delayed. Progress has been ... -
Hypertension, atherosclerosis and fracture risk - observational investigations with focus on antihypertensive therapy
Aim: To investigate associations between hypertension, arteriosclerotic disease, and fracture risk in adults and the elderly, with a certain focus on how specific antihypertensive drug treatments in patients with high blood ... -
Clinical challenges in Cushing's syndrome
Cushing’s syndrome (CS) is caused by prolonged exposure to cortisol excess. CS is associated with cardiovascular diseases, infections, and fractures, as well as with cognitive impairment and affective disorders. This thesis, ... -
Cause-Specific Mortality and Physical Fitness in Mental Disorders - Epidemiological and Internventional Studies
Mental illnesses are common and constitute a substantial health-related and financial burden on both the individual and society. Mental disorders in general have increased risk of somatic morbidity. An early age of onset ... -
Hypertoniscreening - Tidig upptäckt av högt blodtryck via tandvården
Background: Hypertension is the main risk factor for the world’s total disease burden. This is of significance for public health at national level, for healthcare professionals, resource consumption and costs as well as ... -
Thymic exosomes - effects on selection and maturation of thymocytes
T cell tolerance is primarily shaped in the thymus, through direct and indirect presentation of self-antigens to developing T cells. Medullary thymic epithelial cells (mTECs), producing and expressing self-antigens, together ... -
Health locus of control, depressive symptoms, and insulin resistance. Implications for treatment and prevention in general population and primary care
The disease burden of type 2 diabetes and depression is large and challenging for healthcare systems. Preventive interventions require resources and better knowledge concerning early stages in the development of these ... -
The role of the gut microbiota in central energy balance regulation
The gut microbiota can affect development and metabolism in the host. Today, much is still unknown regarding the effects of the gut microbiota on central energy balance regulation. We used mouse models to determine the ... -
Prognosis and clinical outomes in stroke patients with transcatheter closure of an atrial shunt
Background: The percutaneous transcatheter closure of a patent foramen ovale (PFO) after a cryptogenic cerebrovascular event (CVE) has been performed for more than two decades. In contrast with previous randomized studies, ... -
Prediction models for planning health care resources. During the first wave of the Covid-19 pandemic 2020
(University of Gothenburg, 2022)Due to the Covid-19 pandemic, has emphasized a need for planning health care resources based on only a few aggregated data points and little knowledge of the data-generating process. In the first part of the report, we ... -
Metabolic alterations and adipose tissue dysfunction in individuals with a family history of type 2 diabetes
(2022-02-08)ABSTRACT Aims The overall aim of this doctoral thesis was to further examine the anthropometric, metabolic and adipose tissue dysfunctions, as well as explore novel metabolites, associated with type 2 diabetes mellitus ... -
Unmet need for mental healthcare among men Sweden: Gendered pathways to care
(2022-02-02)Aim: Depression and anxiety disorders have a lifetime prevalence of about 10% among men in high-income countries but many do not seek and receive the care that they need. The aim of this thesis was to explore gendered ... -
Predictors of bone fragility in older women. Associations in older women between risk medications and measurements of physical function, bone microstructure and fracture risk
(2021-12-20)Bone fragility with fractures constitutes a growing public health concern, resulting in suffering and major health care cost. This thesis project has been carried out by means of studies based on the SUPERB cohort of ... -
Luftvägsvirus vid arbetsplatser - Smittvägar, riskfaktorer och skyddsåtgärder
(GÖTEBORGS UNIVERSITET Avd för Samhällsmedicin och Folkhälsa, 2021-12-06)Att spridning av sjukdomsframkallande luftvägsvirus kostar samhället enorma resurser har blivit uppenbart för alla under covid-19, men ovälkomna virus har varit människans följeslagare genom hela historien och ständigt ... -
Physicians' practices in sickness certification for common mental disorders - assessment of work capacity and communication with the patient's workplace
(2021-11-25)Physicians are key stakeholders in the sickness certification process. The first aim of this thesis was to examine physicians’ sickness certification practices from two perspectives: the assessment of work capacity and ...
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