Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för medicin by Title
Now showing items 536-555 of 605
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T cell Function in Patients with Dilated Cardiomyopathy
(2008-10-02)Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by dilatation of one or both ventricles together with decreased systolic function. Its etiology is still largely unknown. However, immunological alterations ... -
T cell subsets in asthma and allergy - role of glucocorticoids, plasticity and microRNA-155
(2014-03-28)The focus of this thesis is the different subsets of CD4+ T cells involvement in asthma and allergy. It encloses studies of asthma and allergy in both humans and mice. The work of the three papers has been performed ... -
T cells and chemokines in rheumatoid arthritis
(2021-08-18)In this thesis, we investigated if circulating proportions of specific CD4+ T cell subsets and blood chemokine levels were associated with disease activity and/or could predict remission in patients with early ... -
Telefonrådgivning - en verksamhet i tiden : studier ur ett patient- och sjuksköterskeperspektiv
(2009-11-10)Background : Care encounters and nurses’ advising over the phone are increasingly common in the Western world today. This new area in the profession needs more research due to its’ importance in daily life. Article I: ... -
Tenomodulin, serum amyloid A and the serum amyloid A receptor selenoprotein S – implications for metabolic disease
(2010-05-11)Obesity and obesity-related metabolic diseases are associated with a low-grade inflammation, including slightly increased serum levels of the acute phase protein serum amyloid A (A-SAA). A-SAA is one amongst several ... -
The association between eczema, asthma and rhinitis -population studies of prevalence and risk factors among adults
(2016-04-28)Background: Allergic diseases such as asthma, rhinitis and eczema have increased significantly since the middle of the past century and are now common conditions among both children and adults. The increase was observed ... -
The Clinical Relevance and Potential Mechanism of Biomarkers in Elderly Heart Failure Patients
(2013-05-08)Aim: To study the clinical relevance and potential mechanism of biomarkers in elderly heart failure (HF) patients. Methods: A retrospective study was conducted by access to Swedish Heart Failure Registry with focus on ... -
The effects of stress on atherosclerosis in mice
(2010-11-17)Psychosocial stress has been recognized as an independent risk factor for cardiovascular disease and atherosclerosis. However, little is known about the mechanisms converting this psychosocial load into physical disease. ... -
The fight against time in prehospital cardiac arrest - a true medical emergency
(2020-08-18)ABSTRACT Background: The chances of survival after an out-of-hospital cardiac arrest (OHCA) are one in ten. The majority of survivors have no or relatively mild neurological sequelae. Interventions are time critical and ... -
The Force of Blood
(2021-05-12)Aim: The overarching aim of this thesis was to investigate the prevalence, temporal trends and associations to cardiovascular outcomes of blood pressure levels in patients in Västra Götaland. Methods and findings: In Study ... -
The IL-23 axis and innate immunity in the airways
(2017-11-08)The Interleukin-23 (IL-23) axis is a communication system that integrates innate and adaptive immunity. When triggered by microbial stimuli, antigen presenting cells can secrete the cytokine IL-23, leading to the production ... -
The impact of railway vibration and noise on sleep
(2017-09-25)Sleep is a vital component of good health, and sleep loss is associated with impaired cognition, decreased psychomotor performance, cardiovascular disease, adverse effects on endocrine and metabolic function, negative mood, ... -
The physician and the sickness certification
(2018-01-18)Background and aims: Sickness insurance is a hallmark of most welfare states. The rising costsof sickness insurance in Sweden have been attributed to varying sickness certification practices among physicians. Other factors, ... -
The population burden of gout and urate in Western Sweden
(2021-11-02)Background: Gout is the most common type of inflammatory arthritis and is associated with several comorbidities and an increased risk of cardiovascular disease (CVD). However, data on the epidemiology and comorbidity ... -
The pro-atherogenic role of Intimal hyperplasia
(2016-12-22)Atherosclerosis is a leading cause of mortality worldwide, and results from accumulation of plasma lipoproteins, mainly low-density lipopro-teins (LDL), in the sub-endothelial layer of the arterial wall. In this the-sis, ... -
The role of B cells in rheumatoid arthritis
(2012-03-26)It has been known for a long time that B cells play a role in rheumatoid arthritis (RA). By production of autoantibodies, presentation of auto-antigens and by producing cytokines B cells may contribute to the pathogenesis ... -
The role of estrogen receptor alpha in the regulation of bone and growth plate cartilage
(2012-12-20)Estrogens are important endocrine regulators of skeletal growth and maintenance in both females and males. Studies have demonstrated that the estrogen receptor (ER)-α is the main mediator of these estrogenic effects in ... -
The Role of Estrogen Receptor α Signaling in the Regulation of Bone Mass
(2018-12-06)Estrogens are major regulators of skeletal growth and maintenance in both females and males. Estrogen receptor α (ERα) is the main mediator of estrogenic effects in bone. Thus, estrogen signaling via ERα is a target for ... -
The Role of Insulin and Insulin-like Ischemic Stroke and Cognitive Impairment
(2016-11-02)Background and aims: Insulin, insulin-like growth factor-I (IGF-I), and the six high-affinity IGF-binding proteins (IGFBPs) play an important role in growth, metabolism and regeneration throughout the entire life span. In ... -
The role of insulin-like growth factor-l in Alzheimer's disease and vascular dementia
(2024-03-25)Background and purpose: Insulin-like growth factor-I (IGF-I) is involved in normal brain function, but little is known whether IGF-I activity affects the cognitive continuum of dementing disorders. The overall purpose of ...