Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för medicin by Title
Now showing items 116-135 of 555
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Decellularization as a method to generate a new generation of vascular grafts
(2020-04-29)Decellularization of blood vessels is a technique to remove cells from the extracellular matrix (ECM), which can be used as a vascular graft for peripheral or coronary blood vessel bypass surgery. This thesis focuses on ... -
Defining orellanine as treatment of advanced renal cell carcinoma
(2014-03-28)Renal cancer causes over 100,000 annual deaths worldwide, and the incidence is increasing. Clear cell renal cell carcinomas (CCRCC), constituting 75% of renal cancer, are known for their high metastatic frequency and ... -
Defining RCE1 and ICMT as Therapeutic Targets in K-RAS-induced Cancer
(2009-04-09)CAAX proteins, such as the RAS and RHO proteins, are recognized by a specific CAAX motif at the carboxyl terminus, which undergoes posttranslational modifications. First, a lipid group is attached to the cysteine (the “C”) ... -
Defining the clinical usefulness of vertebral fracture assessment
Objective: Vertebral fractures (VFs) are the most common osteoporotic fracture and among the strongest predictors for future fracture. VFs can be identified by vertebral fracture assessment (VFA) from lateral spine imaging ... -
Defining the importance of protein geranylgeranylation in innate immunity
(2018-11-19)RHO family proteins and other intracellular proteins are prenylated with a 20-carbon lipid—a product of the cholesterol synthesis pathway—by protein geranylgeranyltransferase type I (GGTase-I). Prenylation is widely believed ... -
Defining the Role of GGTase-I in the Development of Rheumatoid Arthritis and Atherosclerosis
(2012-05-08)RHO family proteins control cell movement and intracellular signaling by cycling between active GTP-bound and inactive GDP-bound states. Aberrant signaling of RHO GTPases has been implicated in many diseases including ... -
Determinants of Peak Bone Mass in Men
(2013-01-25)Objective: The aim of this thesis was to identify, investigate and evaluate hereditary and environmental factors associated with peak bone mass or bone development in men. Method: All studies in the thesis were performed ... -
Development and dynamics of the normal gut microbiota
(2020-05-05)Altered gut microbiota configurations have been linked to human diseases. To identify mechanistic links between altered gut microbiota and disease states, definitions of the healthy gut microbiota need to be established. ... -
Development of a New Biomechanical ex vivo Perfusion System - Studies on effects of biomechanical and inflammatory stress on hemostatic genes in human vascular endothelium
(2009-10-06)The vascular endothelium is a multifunctional interface constantly exposed to biomechanical forces such as shear and tensile stress. Biomechanical stress is involved in the pathophysiological process of the vessel wall and ... -
Developmental and cholera toxin-induced alterations in the expression of intracellular signalling molecules
(2013-11-27)The innate immune system represents the first line of host defence that reacts promptly to attacks by microbes. This system relies on several families of pathogen-recognition receptors (PRRs), which recognize pathogen-associated ... -
Diabetes and hypertension - entangled chronic conditions in primary care. Time trends and determinants for mortality and cardiovascular complications.
(2021-03-23)Diabetes and hypertension are chronic, often coexisting conditions with increased risk of premature death and cardiovascular complications. This thesis aimed to study different epidemiological aspects regarding risk of ... -
Diabetes and obesity in primary health care - a condition beyond physiological factors
(2011-11-18)Aims: The objectives of this thesis are to illustrate how obese and normal-weight individuals with type 2 diabetes (T2DM) experience their health status and health care interactions and to highlight the diabetes team ... -
Diagnosis & dietary intervention in patients with diabetic gastroparesis
(2013-09-03)Background: Gastroparesis is a diabetic complication, which is often under-recognised. Existing treatment options are limited and diagnostic methods not easily accessible. Aims of the thesis: To compare two alternative ... -
Diagnosis of interatrial shunts and the influence of patent foramen ovale on oxygen desaturation in obstructive sleep apnea
(2007-11-06)Patent foramen ovale (PFO) is found in 27% of the population and although mostly asymptomatic, PFO has been associated with e.g. cryptogenic stroke and, rarely, also with oxygen desaturation. PFO and atrial septal defects ... -
Diagnostic aspects of urinary tract infections among elderly residents of nursing homes
(2014-05-05)Background: Up to half the residents of nursing homes for the elderly have asymptomatic bacteriuria (ABU), which should not be treated with antibiotics. Thus, it is difficult to know if new symptoms in residents with ... -
DIAVIP - Diabetes Prevention in Primary Care - Implications for Physical Activity
(2014-03-07)Aim: The overall aim was to study the effect of physical activity in impaired glucose tolerance (IGT) and insulin resistance. We set out to: 1. Evaluate different screening instruments to identify individuals with IGT; ... -
Diet and/or exercise treatment for weight loss in overweight and obese women after childbirth
(2012-11-15)AIM: The aim of the research presented in this thesis was to evaluate whether, dietary behavior modification treatment (D), or physical exercise behavior modification treatment (E), or the combination of both (DE), provide ... -
Dietary energy density and energy intake in cancer patients
(2012-10-25)Background & Aims: Cachexia is frequent in advanced cancer and is associated with adverse outcomes; however, definite diagnostic criteria for cachexia are not established. Diet energy density (ED) may affect energy intake ... -
Dietary intake of naturally occurring plant sterols in relation to serum cholesterol and myocardial infarction - Epidemiological studies from Sweden and the UK
(2012-09-21)Cardiovascular diseases (CVDs) are the leading cause of death in the world. High serum level of cholesterol is one of the major risk factors for CVD development. Serum levels of cholesterol can be modified by diet. Generally, ... -
Dietary intake, nutritional status and energy metabolism in adolescents with severe obesity - Effects of gastric bypass surgery
(2020-11-02)Background and aims: Roux-en-Y gastric bypass is an effective obesity treatment in adults and is becoming established in adolescents. Information is scarce on long-term changes in dietary intake, nutritional status and ...