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Arthritis and immune-mediated bone loss - role of estrogen signalling pathways

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Title: Arthritis and immune-mediated bone loss - role of estrogen signalling pathways
Authors: Engdahl, Cecilia
Issue Date: 13-Dec-2012
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Rheumatology and Inflammation Research
Parts of work: Paper I; Cecilia Engdahl, Caroline Jochems, Sara H Windahl, Anna E Börjesson, Claes Ohlsson, Hans Carlsten, Marie K Lagerquist. Amelioration of collagen-induced arthritis and immune-associated bone loss through signaling via estrogen receptor alpha, and not estrogen receptor beta or G protein-coupled receptor 30. Arthritis Rheum. 2010 Feb; 62(2):524-33

Paper II; Cecilia Engdahl, Anna E Börjesson, Annica Andersson, Alexandra Stubelius, Andree Krust, Pierre Chambon, Ulrika Islander, Claes Ohlsson, Hans Carlsten, Marie K Lagerquist. The role of total and cartilage-specific ERα expression for the ameliorating effect of estrogen on arthritis. Manuscript.

Paper III;Ceclia Engdahl, Catharina Lindholm, Alexandra Stubelius, Claes Ohlsson, Hans Carlsten, Marie K Lagerquist. Periarticular bone loss in antigen-induced arthritis. Manuscript.

Paper IV; Cecilia Engdahl, Caroline Jochems, Jan-Åke Gustafsson, Paul T van der Saag, Hans Carlsten, Marie K Lagerquist. In vivo activation of gene transcription via oestrogen response elements by a raloxifene analogue. Journal of Endocrinology. 2009 Dec; 203(3): 349-56

Date of Defence: 2013-01-11
Disputation: Fredagen den 11 januari 2013, klockan 9.00, Förelässningssalen, tredje våningen, Guldhedsgatan10A, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Arthritis
Abstract: Objective: Rheumatoid arthritis (RA) is associated with immune-mediated bone loss and thereby increased risk for fractures. Estrogen and selective estrogen receptor modulators (SERMs) ameliorate not only the incidence and progression of experimental RA but also the immune-mediated bone loss. The aim of this thesis was to elucidate estrogen signaling pathways in arthritis and the associated immune-mediated bone loss. Methods: Arthritis and bone mineral density (BMD) were evaluated in two experim... more
ISBN: 978-91-628-8577-9
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin



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