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Aplastic anemia - a population-based study of epidemiology, treatment, and prognostic factors


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Title: Aplastic anemia - a population-based study of epidemiology, treatment, and prognostic factors
Authors: Vaht, Krista
Issue Date: 3-Sep-2020
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Internal Medicine
Parts of work: I. Vaht K, Göransson M, Carlson K, Isaksson C, Lenhoff S, Sandstedt A, Uggla B, Winiarski J, Ljungman P, Brune M, Andersson P-O. Incidence and outcome of acquired aplastic anemia: real-world data from patients diagnosed in Sweden from 2000-2011.Haematologica. 2017;102(10):1683-1690.
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II. Vaht K, Göransson M, Carlson K, Isaksson C, Lenhoff S, Sandstedt A, Uggla B, Winiarski J, Ljungman P, Brune M, Andersson P-O. Low response rate to ATG-based immunosuppressive therapy in very severe aplastic anaemia - A Swedish nationwide cohort study. European J Haematology. 2018;100(6):613-620.
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III. Vaht K, Göransson M, Carlson K, Isaksson C, Lenhoff S, Sandstedt A, Uggla B, Winiarski J, Ljungman P, Andersson P-O, Brune M. High Graft-versus-Host Disease-Free, Relapse/Rejection-Free Survival and Similar Outcome of Related and Unrelated Allogeneic Stem Cell Transplantation for Aplastic Anemia: A Nationwide Swedish Cohort Study. Biology of Blood and Marrow Transplantation. 2019;25(10):1970-1974.
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IV. Vaht K, Brenner J, Bram Ednersson S, Ljungman P, Brune M and Andersson P-O. Bone marrow expression of CD68/CD163 macrophages, IL-17 and FOXP3 cells in aplastic anemia and their relation to prognosis. Manuscript
Date of Defence: 2020-10-08
Disputation: Torsdagen den 8 oktober, kl.9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: aplastic anemia
Abstract: Background and aims. Aplastic anemia (AA) is a rare but life-threatening disease. The introduction of immunosuppressive treatment (IST) and hematopoietic stem cell transplantation (HSCT) has considerably improved the outcome of patients with AA. However, modern-day population-based data are limited. This thesis aimed to retrospectively analyze the incidence, treatment modalities, survival, and immune markers in the bone marrow of patients diagnosed with AA in Sweden from 2000–2011. Patients an... more
ISBN: 978-91-7833-970-9(PRINT)
978-91-7833-971-6(PDF)
URI: http://hdl.handle.net/2077/64522
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin

 

 

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