Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för medicin by Title
Now showing items 155-174 of 604
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Early childhood thymectomy - impact on immune function
(2017-05-10)Introduction: The thymus is the site of T cell maturation. Children born with a congenital heart defect often endure surgery early in life, and during surgery their thymus is routinely removed, as it blocks the surgeons ... -
Echocardiographic assessment and B-type natriuretic peptide for risk evaluation in acute coronary syndromes
(2010-12-16)Acute coronary syndromes (ACS) is one of the most common causes of emergency medical care and the single most common cause of death in Sweden in both men and women. Despite a significant improvement in survival in the ... -
Economic impact of drug-related morbidity in Sweden - Estimated using experts’ opinion, medical records and self-reports
(2014-05-05)Drug-related morbidity is an important public health concern, but knowledge about its economic impact is limited to hospitals. Thus, important consequences to the general public may have been overlooked. The aim of the ... -
The economics of a silent pandemic - A health economic analysis of antibiotic resistance in Sweden
(2022-08-16)The overall aim of this thesis was to analyze the health economic consequences of antibiotic resistance in Sweden, and to assess the implications of methodological assumptions related to measuring health in health economic ... -
The effect of hypoxia on macrophage proteoglycans: potential role in atherosclerosis
(2009-11-13)A critical step in the development of atherosclerotic lesions appears to be the retention of low density lipoproteins (LDL) in the arterial wall, mediated by negatively charged proteoglycans (PG). Retained LDL is susceptible ... -
Effects of an intervention and an organisational implementation for identification and treatment of common mental disorders in primary healthcare
(2021-05-26)Aim: This thesis aimed to evaluate the effects of one intervention and one organisational implementation for identification and treatment of common mental disorders (CMDs) in the primary healthcare in Region Västra Götaland, ... -
Effects of Biomechanical Stress on Gene Regulation in Vascular Cells
(2007-11-16)The vascular vessel wall is constantly exposed to biomechanical forces, such as shear and tensile stress. Biomechanical forces are important for several physiological and pathological processes and have been shown to ... -
Effects of gastric bypass surgery in patients with obesity and type 2 diabetes
(2019-05-17)Background: The effects of Roux-en-Y gastric bypass (GBP) have not been adequately explored in patients with concurrent obesity and type 2 diabetes mellitus (T2DM) to the same extent as has occurred for individuals with ... -
Effects of growth hormone in the hippocampus and cortex of adult rodents
(2016-12-07)Background and Aims: Growth hormone (GH) affects proliferation, regeneration and specific plasticity in the adult brain. We aimed to investigate new mechanisms of local and circulating GH in the brain, and to explore the ... -
Effects of immunosuppressive drugs on human adipose tissue metabolism
(2012-10-26)The immunosuppressive agents (IAs) rapamycin, cyclosporin A and tacrolimus, as well as glucocorticoids are used to prevent rejection of transplanted organs and to treat autoimmune disorders. Despite their desired action ... -
Effects of microbial metabolites on host physiology
(2015-08-24)In recent years it has become increasingly clear that the gut microbial community, the microbiota, has a vast impact on obesity, insulin signaling and glucose homeostasis. More specifically, there are microbiota-derived ... -
Effects of oestrogen on haemodynamic and vascular reactivity - A study in animal models and humans
(2007-04-28)Effects of Oestrogen on Haemodynamic and Vascular Reactivity A study in animal models and humans Lisa Brandin Institute of Medicine, Department of Emergency and Cardiovascular Medicine, Sahlgrenska University Hospital/Östra, ... -
Elemental composition of fine particles: exposure in the general population and influence from different sources
(2007-03-02)The general population is exposed to particulate air pollution from many different local and regional sources. Examples of local sources are traffic, biomass burning and resuspended dust, while regional sources are ... -
Elevated calcium concentration, is it dangerous? Long-term follow-up in primary care
(2014-02-12)Background and aims: Patients with hypercalcaemia are relatively common in primary care; the most frequent causes are primary hyperparathyroidism (pHPT) and cancer. Many patients with pHPT have such discrete symptoms that ... -
Emerging viruses in organ transplant recipients - immune responses to H1N1/09 influenza vaccine and Hepatitis E virus infection
(2017-03-16)Solid organ transplant (SOT) recipients run the risk of serious infections. The pandemic influenza A H1N1/09 had unknown severity, so large-scale vaccination was needed. The AS03-adjuvanted vaccine (Pandemrix) had unknown ... -
Endocrine and diagnostic aspects of cognitive impairment
(2013-04-30)Hormones like insulin-like growth factor-I (IGF-I), thyroid hormones, and sex steroids decrease with normal aging. It is, however, unclear whether low hormone levels are related to age-related conditions such as Alzheimer’s ... -
The endocrine system in the progression of mild cognitive impairment to dementia
(2022-05-23)Background and aims: Endocrine alterations have been related to cognitive decline, but the role of hormones may vary along the progression to manifest dementia. The overall aim of this thesis was to assess whether thyroid ... -
Endogenous and microbial modulators of inflammation
(2023-12-05)Cardiometabolic disease is characterized by dysregulated, chronic inflammation, that may result from impaired resolution pathways or alterations in the gut microbiota. Thus, restoring specialized pro-resolving mediators ... -
Endogenous sex hormones and cardiometabolic risk factors – population-based studies within the Skaraborg Project
(2022-12-21)Cardiovascular diseases are the major contributors to mortality in Sweden and globally. Men have a higher incidence of cardiovascular diseases compared to women, until women reach the menopause. Levels of sex hormones ... -
Endogenous t-PA release and pharmacological thrombolysis - Experimental animal studies of the coronary circulation
(2006-10-25)Abstract The physiologically most important activator of intravascular fibrinolysis is tissue-type plasminogen activator (t-PA) released from endothelial cells. In man, sympathomimetic drugs increase the systemic concentration ...