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Socioekonomiska aspekter av diabetes och kardiovaskulär sjukdom
(2015-06-04)Four hundred million people in the world have diabetes. The incidence of type 1 diabetes has increased steadily in the last few decades and it is now the second most common chronic disease of childhood. Type 2 diabetes ... -
Statins, Lipids, and Mutations: Consequences for the Heart and Immune System
(2019-08-14)CAAX proteins are a group of proteins that undergo a three-step protein maturation process that renders the proteins carboxyl-terminus hydrophobic and prone to localize to cellular membranes, where they have their primary ... -
STK25 as a regulator of lipid accumulation
(2018-08-24)Type 2 diabetes mellitus (T2DM) and nonalcoholic steatohepatitis (NASH), a progressive form of nonalcoholic fatty liver disease (NAFLD), have become widespread metabolic disorders that have reached epidemic proportions. ... -
STK25- a new key regulator of metabolic profile and a possible target for anti-diabetic drug
(2017-11-02)Type 2 diabetes (T2D) affects at least 285 million people worldwide and its prevalence is rapidly increasing. Understanding the molecular mechanisms controlling ectopic lipid deposition and insulin response in metabolic ... -
Storage organelles that are distinct from the classical granules in human neutrophils
(2006-12-27)The human neutrophil is a crucial participant in acute inflammation. Appropriate immune response is dependent on rapid direction of phagocytic cells through the tissue, towards the inflammatory focus. Such movement is ... -
Stratification and model-based analysis of patients with Irritable Bowel Syndrome using advanced biostatistics and medical data mining techniques
(2018-05-24)ABSTRACT Irritable Bowel Syndrome (IBS) is characterized by symptoms that are dominated by abdominal pain and abnormal bowel habits, as defined by the Rome criteria. The complexity of the disorder is exemplified by the ... -
Stroke: Risk Factors and Trends
(2014-11-04)Stroke is a severe disease that affects 30,000 people in Sweden every year. Three quarters of stroke events are first time events. The risk of premature death and disability is high among stroke survivors. Knowledge about ... -
Studies of atherogenic lipoproteins using mass spectrometry-based lipidomics
(2010-09-03)The prevalence of type 2 diabetes is increasing worldwide and is about to reach epidemic proportions. The disease is often associated with dyslipidemia which is characterized by an atherogenic lipoprotein profile including ... -
Studies of Neutrophilic Inflammation in Tobacco Smokers
(2014-12-04)Studies of neutrophilic inflammation in tobacco smokers Kristina Andelid Department of Internal medicine and clinical nutrition, Institute of Medicine Sahlgrenska Academy at University of Gothenburg Göteborg, ... -
Studies of risks associated with atrial fibrillation
(2010-10-25)Aim: To investigate temporal trends in the risk of mortality and stroke associated with incident atrial fibrillation (AF) in Sweden. To investigate the risk of morbidity and mortality associated with prevalent and incident ... -
Studies on carotid plaque vulnerability using contrast enhanced ultrasound
(2015-10-14)ABSTRACT Background and Aim: Contrast-enhanced ultrasound is a method to examine neovessels that may be present inside the atherosclerotic plaque of the carotid arteries. These neovessels are believed to be involved in ... -
Studies on microcirculation in insulin resistance
(2015-11-26)The overall aim of this thesis was to investigate the microcirculation in insulin resistance, with focus on the expression of endothelin-1, through a translational approach. Specific aims: 1) Investigate if circulating ... -
Studies on the atherogenicity of apoB-containing lipoproteins in type 2 diabetes
(2009-01-15)Type 2 diabetes (T2D) and the metabolic syndrome (MetS), two conditions that are rapidly increasing in prevalence, as well as the dyslipoproteinemia and subclinical inflammation characteristic for these conditions, are ... -
Studies on treatment of renal anemia in patients on chronic hemodialysis
(2011-05-23)In patients with chronic kidney disease, treatment with erythropoiesis-stimulating agents (ESA) effectively corrects anemia. Most of these patients also need supplementation with regular iron injections to secure iron ... -
Surgical management of aortic prosthetic valve endocarditis
(2016-01-25)Background: Infective endocarditis (IE) is still associated with high mortality and morbidity despite advances in diagnostic, medical and surgical management. Aims: I. To report short- and mid-term results after surgical ... -
Surveillance of childhood obesity in Sweden. Focus on lifestyles and socioeconomic conditions.
(2014-09-05)Background and aim: There is a general lack of childhood obesity surveillance systems throughout Europe, including Sweden. Such systems are needed to develop policies, evaluate interventions and track secular changes in ... -
Susceptibility to chronic liver disease
(2015-03-06)The onset and the progression of chronic liver disease involve environmental and genetic factors. Hepatic stellate cells (HSCs) are important players in these processes and are the main storage site for retinol. We studied ... -
Swedish Pharmaceutical Benefit Reforms - Analyses of implementation, pharmaceutical sales patterns and expenditures
(2006-10-24)Background: Over the last few decades, the sales of prescription drugs have increased dramatically in many western countries; however, this increase requires individuals and society to bear larger economic consequences. ... -
Symptom patterns in irritable bowel syndrome
(2019-10-23)Who has never had them: symptoms in the abdominal region, such as pain, bloating, constipation, and diarrhoea? These are common symptoms of irritable bowel syndrome (IBS). IBS affects 5-10% of the population, especially ... -
Symptomatic Carotid Stenosis - optimal timing of surgical treatment
(2017-10-17)Abstract In patients with symptomatic carotid artery stenosis is convincing evidence that carotid endarterectomy (CEA) confers maximum benefit if performed within 14 days from index event. Patients with TIA or minor stroke ...