Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för medicin by Title
Now showing items 572-591 of 604
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Ultrasound assessment of carotid atherosclerosis focusing on plaque characteristics and changes over time
(2011-05-26)In a clinical perspective better methods to identify subjects at increased cardiovascular risk are needed. Atherosclerotic plaques of the carotid arteries with low echogenicity have been related to future clinical events. ... -
Ultrasound evaluation of atherosclerosis and other cardiovascular sources of cerebral embolism
(2008-01-18)The search for embolic sources has high priority in patients presenting with suspected cerebral embolism. Non-invasive cardiovascular ultrasound is frequently used to reveal the presence of carotid stenosis and cardiac ... -
Understanding the genetic architecture of fatty liver disease
(2022-11-29)Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease, ranging from simple steatosis to more severe conditions, namely non-alcoholic steatohepatitis (NASH), liver fibrosis, cirrhosis, ... -
Understanding the molecular mechanisms of bile acid receptor activation for the treatment of human liver disease
(2020-04-30)Farnesoid X receptor (FXR) is a nuclear transcription factor that is activated by bile acids and regulates bile acid homeostasis, glucose and lipid metabolism. FXR activation by a ligand has been identified as a therapeutic ... -
Unmet need for mental healthcare among men Sweden: Gendered pathways to care
(2022-02-02)Aim: Depression and anxiety disorders have a lifetime prevalence of about 10% among men in high-income countries but many do not seek and receive the care that they need. The aim of this thesis was to explore gendered ... -
Urinary Clara cell protein and alpha 1-microglobulin – biomarkers of changes in kidney and airway function
(2010-04-13)Validated biomarkers are useful tools for screening large populations. The benefit of screening may be improved risk assessment or early indications of adverse effects before detection or onset of symptoms. Screening is ... -
Utmattningssyndrom, identifikation, karakteristika och förlopp
(2014-05-09)Aim. The overall aim of the thesis was to study exhaustion disorder (ED) with respect to identification, characterisation and course of illness, as well as some properties of an instrument of self-rated ED (s-ED). Method. ... -
Utvecklad dialog om sexuell hälsa med fokus på unga kvinnor - en möjlighet vid det gynekologiska besöket
(2009-11-19)Background: Many women who have sexual problems or who have been subjected to sexual abuse do not seek help and health professionals often avoid raising such issues. The gynaecological encounter could be an opportunity ... -
Vaccine responses after chemotherapy or stem cell transplantation in patients with hematological malignancies
(2022-09-22)The prevention of infections in patients with hematological malignancies is important given the inherent immune deficiency associated with these diseases and the immunosuppressive effects of treatment. This thesis investigated ... -
Vascular and metabolic effects of selective PDE-5 inhibition - clinical and experimental studies
(2015-02-13)ABSTRACT Vascular and metabolic effects of selective PDE-5 inhibition Clinical and experimental studies Lovisa Sjögren Department of Molecular and Clinical Medicine, Institute of Medicine at Sahlgrenska Academy, ... -
Vascular Function in Chronic Renal Failure
(2014-02-21)A majority of patients with chronic kidney disease (CKD) die of cardiovascular (CV) disease before reaching end-stage renal disease. The causes of CV death in CKD are characterized by an excess of sudden cardiac deaths ... -
Vascular Wall Responses to Bypass Grafting - Studies in Mice
(2008-01-18)Abstract Vein grafts are frequently used in bypass surgery for treatment of coronary artery disease and lower limb ischemia. Unfortunately the long-term patency is impaired by vein graft stenoses due to intimal hyperplasia ... -
Vectorcardiographic evaluation of ventricular repolarization in healthy individuals and LQTS mutation carriers
(2013-08-27)Ventricular arrhythmia is a well-known cause of syncopal attacks and sudden cardiac death in humans. Ventricular repolarization (VR) is the most unstable phase in cardiac electrical activity and its regulation depends on ... -
Venous thromboembolism: Risk factors, comorbidities, and treatment-associated risk of bleedings
(2023-11-16)Background: Venous thromboembolism (VTE) is the third most common cardiovascular disease, consisting mainly of deep vein thrombosis (DVT) and pulmonary embolism (PE). Since VTE often is a preventable disease, knowledge of ... -
Vitamin A and Bone: Studies in vivo and in vitro
(2018-11-28)Background: Excess vitamin A is associated with decreased cortical bone and increased risk of fractures in humans. The aim of the present thesis was to assess the importance of vitamin A on the skeleton and bone cells in ... -
Vitamin B12 and folate depletion in the elderly Diagnosis, clinical correlates and causes
(2006-11-10)Subclinical vitamin B12 and folate deficiency is common in the elderly. The clinical significance remains unresolved. There is not a universally accepted set of laboratory criteria for diagnosis, however subclinical ... -
Vitamin D during pregnancy in relation to childhood growth, overweight and obesity
(2023-05-15)The aim of this thesis is to investigate the association between maternal vitamin D intake and status in pregnancy and the child´s growth and risk of overweight and obesity in childhood. Data from the Norwegian Mother, ... -
Vitamin D in Somali women living in Sweden
(2018-10-02)Introduction: Sunlight is the major source of Vitamin D synthesis. Information regarding vitamin D, bone status and general health in Somali women living in Sweden is limited. Vitamin D binding protein (DBP) is the major ... -
Vitamin D status and skeletal changes during reproduction- A longitudinal study from late pregnancy through lactation
(2015-09-25)Low vitamin D status has been associated with sub-optimal bone health. During both pregnancy and postpartum, it has been speculated that vitamin D status may affect maternal bone health, due to its importance in maintaining ... -
Weight loss studies in obese patients. Aspects of very-low-energy diet treatment and effects of obesity surgery on disability pension
(2010-03-02)Obesity is associated with increased risk of serious medical conditions, impaired quality of life, reduced working capacity, and shortened life expectancy. Obesity surgery is the most effective weight loss treatment with ...