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STK25- a new key regulator of metabolic profile and a possible target for anti-diabetic drug

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Title: STK25- a new key regulator of metabolic profile and a possible target for anti-diabetic drug
Authors: Nuñez-Durán, Esther
Issue Date: 2-Nov-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Molecular and Clinical Medicine
Parts of work: I. Urszula Chursa, Esther Nuñez-Durán, Emmelie Cansby, Manoj Amrutkar, Silva Sütt, Marcus Ståhlman, Britt-Marie Olsson, Jan Borén, Maria E. Johansson, Fredrik Bäckhed, Bengt R. Johansson, Carina Sihlbom, and Margit Mahlapuu. Overexpression of Protein Kinase STK25 in Mice Exacerbates Ectopic Lipid Accumulation, Mitochondrial Dysfunction, and Insulin Resistance in Skeletal Muscle. Diabetologia 2017, 60(3):553-567

II. Esther Nuñez-Durán, Belén Chanclón, Silva Sütt, Joana Real, Hanns-Ulrich Marschall, Ingrid Wernstedt Asterholm, Emmelie Cansby, and Margit Mahlapuu. Protein Kinase STK25 Aggravates the Severity of Non- Alcoholic Fatty Pancreas Disease in Mice. Journal of Endocrinology 2017, 234(1):15-27

III. Esther Nuñez-Durán, Mariam Aghajan, Manoj Amrutkar, Silva Sütt, Emmelie Cansby, Sheri L. Booten, Andrew Watt, Marcus Ståhlman, Norbert Stefan, Hans-Ulrich Häring, Harald Staiger, Jan Borén, Hanns-Ulrich Marschall, and Margit Mahlapuu. Stk25 Antisense Oligonucleotide Treatment Reverses Glucose Intolerance, Insulin Resistance and Nonalcoholic Fatty Liver Disease in Mice. Hepatology Communications. Under review
Date of Defence: 2017-11-24
Disputation: Fredagen den 24 November 2017, 13.00, Hörsal Ivan Östholm, Medicinaregatan 13, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Type 2 Diabetes
Insulin resistance
Abstract: Type 2 diabetes (T2D) affects at least 285 million people worldwide and its prevalence is rapidly increasing. Understanding the molecular mechanisms controlling ectopic lipid deposition and insulin response in metabolic tissues is essential for developing new pharmacological strategies to effectively treat T2D. Obesity and overweigh are the main risk factors for developing T2D, but nonalcoholic fatty liver disease (NAFLD) also contributes to the pathogenesis of T2D. Today, achieving good g... more
ISBN: 978-91-629-0286-5 (PRINT)
978-91-629-0287-2 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin



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