Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för medicin by Title
Now showing items 331-350 of 604
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Managing irritable bowel syndrome - Dietary approaches and food intolerance
(2021-05-11)Irritable bowel syndrome (IBS) is a complex disorder where diet plays a pivotal role in symptom generation for many patients. The aim of this thesis was to explore how diet and self-perceived food intolerance relate to ... -
Manifestations and Survival in Coronary Heart Disease
(2009-01-15)Aim: To investigate how risk factors predict manifestations in coronary heart disease (CHD), and trends in short-term and long-term survival including trends in out-of-hospital mortality. Populations and methods: In the ... -
Mechanical circulatory support in advanced heart failure - patient selection, treatment strategies and outcomes
(2022-09-19)Background: Heart transplantation (HTx) remains the major treatment option for selected patients with end-stage heart failure. In hemodynamically unstable patients, or when there is a considerable risk of deterioration ... -
Mechanical circulatory support in patients with severe heart failure
(2010-05-11)Severe heart failure has a poor prognosis. Mechanical circulatory support (MCS) is capable of assisting the circulation in selected patients to bridge them to heart transplantation or recovery of heart function. MCS is ... -
Mechanism of F-actin crosslinking by filamin A and the anti-inflammatory functions of plasma gelsolin in bodily fluids
(2007-09-10)Gelsolin (GSN) and filamin A (FLNa) are two actin-binding proteins discovered in our laboratory over 30 years ago. GSN is a calcium-activated actin severing and barbed end capping protein that is expressed as both intracellular ... -
Mechanisms for and consequences of cellular lipid accumulation - Role of the Very Low Density Lipoprotein (VLDL) receptor
(2011-12-02)Lipid accumulation in non adipose tissue is associated with various cases of tissue dysfunction and tissue failure. Reduced availability of oxygen is known to cause intracellular lipid accumulation in cardiomyocytes as ... -
Mechanisms underlying inflammation, symptoms and quality of life in ulcerative colitis
(2021-10-06)A substantial proportion of patients with ulcerative colitis (UC) in remission demonstrate gastrointestinal (GI) symptoms, despite the absence of ongoing inflammation in the colon. The underlying mechanisms of these symptoms ... -
Medical problems associated with spinal cord lesions - impact on functioning
(2006-09-01)Aims: The overall aim of this thesis was to study the effects of medical problems associated with spinal cord lesions on functioning - with special interest in work participation and sexual functioning. A special aim was ... -
Medical students' learning of the consultation and the patient-doctor relationship
(2007-05-04)Background: In medical education, learning about the consultation and the patient-doctor relationship is nowadays highly recommended. However, research from educational practice from students’ perspective is needed to ... -
Medication adherence, side effects and patient-physician interaction in hypertension
(2006)Hypertension is an important risk factor for cardiovascular disease, the incidence of which it is possible to reduce by prophylactic treatment with antihypertensive drugs. In clinical practice, however, only a minority of ... -
Membrane Proteins in Human Neutrophils - Identification and Characterization of Lipid Rafts in Subcellular Organelles
(2006-09-29)The human neutrophil is an important effector cell in acute inflammation and in the innate immune response against bacteria and fungi. When immune reactions occur in the tissue in response to antigen challenge, neutrophils ... -
Membranous Nephropathy - Challenges in diagnostics and treatment
(2016-04-04)The variability in the pathogenesis, clinical presentation and outcome of membranous nephropathy (MN) poses major clinical challenges and raises different questions, both regarding diagnostics and treatment of patients ... -
Metabolic alterations and adipose tissue dysfunction in individuals with a family history of type 2 diabetes
(2022-02-08)ABSTRACT Aims The overall aim of this doctoral thesis was to further examine the anthropometric, metabolic and adipose tissue dysfunctions, as well as explore novel metabolites, associated with type 2 diabetes mellitus ... -
Metabolic aspects of cardiac arrhythmias
(2012-05-07)Cardiac arrhythmias are an important cause of mortality and morbidity in patients with cardiac diseases. Sudden death due to ventricular tachycardia and fibrillation (VT/VF) in the setting of acute myocardial infarction ... -
Microarray analysis of gene expression in human adipocytes and adipose tissue
(2008-02-21)Obesity has reached epidemic proportions worldwide and is associated with several serious conditions such as insulin resistance, type 2 diabetes, hyperlipidemia and atherosclerosis. Adipose tissue exerts important endocrine ... -
Microbial modulation of metabolic diseases
(2018-09-13)The gut microbiota, the ensemble of microorganisms living in the gastrointestinal tract, and the host have a mutualist relationship. Alterations of this delicate equilibrium can lead to changes in microbiota composition ... -
Microbial regulation of Insulin-like peptide 5 and its implication on metabolism and bariatric surgery
(2016-05-23)The microbial community in our gastrointestinal tract, the gut microbiota, has great impact on our physiology. Particularly, the role for gut microbiota in host health and disease has been associated with modulation of gut ... -
Mild to moderate depression in the elderly in primary care - detection, patient centeredness and course
(2012-11-02)Aims; To study the prevalence of and describe factors associated with depressive symptoms and to observe the course in a cohort of elderly primary care patients with mild to moderate depression. To compare a structured ... -
Modulation of Receptor Signaling and Functional Selectivity in Neutrophils
(2017-10-17)Neutrophils are important effector cells of the innate immune system and in the regulation of inflammation. Many of their functions, such as chemotactic migration, secretion of granule constituents and activation of the ... -
Modulatory role of IL-17 in airway inflammation
(2010-05-11)IL-17 orchestrates the accumulation of neutrophils to sites of infection and the release of microbicidal substances, and therefore plays a critical role in the innate immune response to infection. IL-17 is also involved ...