Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för medicin by Title
Now showing items 375-394 of 604
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Obesity - surgical treatment and molecular mechanisms
(2015-11-11)Obesity is a condition of high prevalence and is associated with increased morbidity and mortality. Bariatric surgery is an effective treatment of obesity and reduces the risk for morbidity and mortality, but little is ... -
Obesity in diabetes. Cardiovascular outcomes and risk factor trajectories
(2021-03-23)Introduction: The association between body mass index (BMI) and mortality in diabetes is complex and sparsely investigated for cardiovascular (CVD) outcomes. We aimed to investigate these relationships among patients ... -
Obesity, Weight Loss and Cardiovascular Risk
(2020-05-26)Background: The global prevalence of obesity is on the rise, contributing to increased incidence and prevalence of cardiovascular morbidity and mortality. Obesity has adverse effects on cardiac structure and function, ... -
Obstructive Sleep Apnea in Cardiovascular Disease - Mechanisms and Impact of Treatment
(2015-10-29)ABSTRACT Background: Scientific understanding of obstructive sleep apnea (OSA) has increased exponentially during recent decades, suggesting a link between OSA and cardiovascular disease. Few randomized controlled trials ... -
Obstructive sleep apnea in coronary artery disease: Impact of CPAP treatment
(2016-04-05)Obstructive Sleep Apnea in Coronary Artery Disease: Impact of CPAP treatment Helena Glantz Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, ... -
Occupational heat exposure and kidney disease - Studies on the role of heat stress in the Mesoamerican epidemic of Chronic Kidney Disease of non-traditional origin
(2022-05-19)This thesis examines the association between heat stress and kidney disease in Mesoamerica using different perspectives and methods. An ecologic study found that hot, sugarcane-cultivating regions had elevated chronic ... -
On cellular sources for intimal hyperplasia after vascular interventions
(2007-05-24)Vascular interventions for the treatment of symptomatic atherosclerosis fail in up to 40 % of the cases during the first year. One important reason is the development of a narrowing process known as intimal hyperplasia ... -
On kidney dysfunction in advanced liver disease
(2022-11-10)Aims: The overall aim of this thesis was to characterize factors affecting kidney function in advanced liver disease as well as after liver transplantation and to further understand the complex interaction between acute ... -
On the causes of ventricular arrhythmia, its treatment and outcome
(2011-11-25)On the causes of ventricular arrhythmia, its treatment and outcome Christina Holmgren Institute of Medicine Sahlgrenska Academy at University of Gothenburg Göteborg, Sweden ABSTRACT Background: Ventricular arrhythmia ... -
On the effects of obesity treatment
(2021-05-12)Aim: In this thesis the effects of bariatric surgery in individuals with type 1 diabetes (T1D) will be assessed as well as the effects of surgery on risk for heart failure (HF) and atrial fibrillation (AF) in individuals ... -
On the regulation of immune responses to dietary and self antigens
(2010-02-04)Regulatory mechanisms are necessary to avoid the misdirected aggressive immune responses responsible for the pathology seen in autoimmunity and allergy. Thymic-derived CD4+CD25+ regulatory T cells are indispensible for ... -
On the role of gut microbiota in intestinal physiology and hepatic metabolism
(2017-03-03)The gut microbiota, a complex and dynamic community of microbes in the mammalian gut, has coevolved with us for ample time providing mutual benefits. However, mechanistic knowledge of these has been limited, but are now ... -
On viral infections in lung transplant recipients
(2017-12-15)Viral infections are the most common type of infection in humans. Lung transplantation (LTx) recipients are exceptionally susceptible to infections in general, and the short- and long- term effects tend to be more detrimental. ... -
Open heart surgery and its consequences for well-being - the perspectives of patients, relatives and health care professionals
(2008-05-23)Introduction: Adjustment to open heart surgery (OHS) is complex and necessitates multidimensional explanations. The surgery does not always provide the desired outcome, which can contribute to reduced well-being among ... -
Optimizing the early treatment of a threatening myocardial infarction
(2013-01-09)Acute myocardial infarction is the single most common cause of death for both women and men in Sweden. Great efforts have, over the years, been made to improve immediate treatment and care of acute coronary syndromes. Through ... -
Osteoporosis in SLE
(2008-12-03)As the treatment of Systemic Lupus Erythematosus (SLE) has become more effective the focus has partly shifted from main concern of short term morbidity and survival to long term complications such as osteoporosis. The aims ... -
Ostructive lung disease - occupational exposures, smoking and airway inflammation
(2017-02-06)Abstract Obstructive lung disease is a group of respiratory diseases characterized by airways obstruction. Among them the more frequent are asthma and chronic obstructive pulmonary disease (COPD). Obstructive lung ... -
Outcome of Graves disease
(2020-02-05)Graves' disease (GD) is an autoimmune condition with elevated thyroid hormone levels and symptoms suggesting an affected brain. These symptoms often resolve with treatment but, for some patients, GD results in a long period ... -
Outcomes in treated hypertensive men - a follow-up during three decades
(2007-05-24)Objectives: To analyse survival, cause specific mortality and cardiovascular morbidity in relation to cardiovascular risk factors, to investigate the prevalence of type 2 diabetes and the cardiovascular risk this constitutes ... -
Outcomes of invasive treatment in chronic limb-threatening ischaemia
(2023-10-03)Background In chronic limb-threatening ischaemia (CLTI), obstruction of the arterial blood flow causes ischaemic rest pain, ulcers or gangrene in the lower extremities. Patients with CLTI have a substantial risk of ...