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Macrophages in Crohn's Disease: lnnate immune cellular and molecular mechanisms driving intestinal inflammation and fibrosis
(2023-11-22)Macrophages and their interactions with the lamina propria and luminal microenvi-ronment are crucial in the pathogenesis of Crohn´s disease (CD), a chronic inflamma-tory disease with a strong inflammatory innate immune ... -
Mass spectrometric analyses of proteoglycans - Novel tools for studying prohormones in insulin-producing cells
(2020-12-15)Proteoglycans (PGs) are proteins that carry one or more negatively charged glycosaminoglycan (GAG) chains. Proteoglycans have been identified in essentially all multicellular organisms, and are implicated in a wide range ... -
Mass spectrometry for comparative proteomics of degenerative and regenerative processes in the brain
(2006-12-01)Biological processes involve changes at the protein level. Proteomics aims to determine protein changes from a normal state, to measure for instance recovery or disease progression. Mass spectrometry is the most important ... -
Measurement of sensitivity to DNA damaging agents
(2017-08-18)There is a large inter-individual variation in intrinsic sensitivity in patients receiving treatment with DNA damaging agents. Cancer therapy exemplifies this problem where patients experience varying degree of normal ... -
Measurements of the DNA double-strand break response
(2012-09-25)Radiotherapy and some chemotherapeutic drugs kill cancer cells by induction of the extremely toxic DNA double-strand breaks (DSBs). Measurements of the DSB response in patients during therapy could allow personalized ... -
Mechanisms of dendritic cell maturation induced by intracellular bacteria infection
(2007-10-02)Dendritic cells (DCs) are essential for the development of an immune response against pathogens such as Listeria monocytogenes and Salmonella typhimurium. This is mostly because of their unique capacity to stimulate naïve ... -
Mechanisms of leukemia-induced immunosuppression
(2012-05-25)This thesis aimed to define the role of reactive oxygen species (ROS), produced by the NADPH oxidase of myeloid cells, in the regulation of lymphocyte function with focus on ROS-induced dysfunction of natural killer (NK) ... -
Mechanistic studies of the adjuvant effects of CTA1-DD and the native cholera toxin: Impact of cell targeting and tissue localization
(2012-05-15)Vaccines are the most effective means of preventing infectious diseases and improving global health. However, few vaccines have successfully been developed for protection at mucosal surfaces where most pathogens gain access. ... -
Mediator and cell cycle regulation
(2015-11-04)The multiprotein Mediator complex is an evolutionarily conserved coregulator of eukaryotic transcription. Mediator functions as a bridge between gene-specific transcription factors and the RNA polymerase II transcription ... -
Mediator and its role in non-coding RNA and chromatin regualtion
(2014-05-15)Mediator is a multiprotein complex required for the regulation of RNA Polymerase II (Pol II) transcription. Mediator transmits regulatory signals from activators and repressors to the Pol II machinery at the promoter, but ... -
Methods for evaluation of early bone healing at titanium implants
(2008-10-03)Titanium has for a long time been the implant material of choice when in need for abilities as strength, biocompatibility and stability. Although numbers of studies have been made, little is known about the early events ... -
Microbiota of the alimentary tract of children - implications for allergy and inflammatory bowel disease
(2014-09-19)Allergy, which is the most common chronic disease in Swedish children and adolescents, is associated with a high standard of living and Western lifestyle. According to the hygiene hypothesis, allergy is due to inadequate ... -
Molecular analysis of the FET family fusion oncoprotein FUS-DDIT3
(2012-12-20)Chromosomal translocations leading to formation of tumor type specific fusion oncogenes are frequently found in human cancers. The FET family genes (FUS, EWSR1 and TAF15) occur in translocations with genes encoding various ... -
Molecular and genetic studies in high-risk neuroblastoma
(2021-02-04)Neuroblastoma is the most common and deadly cancer in the first year of life. Children with high-risk neuroblastoma have a very poor prognosis, despite heavy multimodal treatment, with less than 50% of 5 years of overall ... -
Molecular and genetic studies of DLG2 in neuroblastoma and colorectal cancer
(2022-05-19)Neuroblastoma is one of the most common extra cranial solid tumors in children. It is one of the most common causes of death amongst the pediatric malignancies. There is however a large difference between the low risk ... -
Molecular and structural studies of proteins required for mitochondrial DNA maintenance
(2022-04-28)Mitochondria are membrane-bound organelles that produce the majority of ATP used to drive metabolic processes in eukaryotic cells. A unique feature of mitochondria is the existence of a separate mitochondrial DNA (mtDNA), ... -
Molecular aspects on Herpes simplex virus type 1 DNA replication and gene expression
(2017-12-22)Herpesviruses infect a variety of animals from molluscs to humans and they have evolved in a close relationship with their hosts. In humans, we find nine herpesviruses, representing all three subfamilies of the family ... -
Molecular biosignatures and gut-barrier alterations in inflammatory bowel diseases
(2022-08-23)Inflammatory bowel diseases (IBD) are chronic immune-mediated disorders affecting the gastrointestinal tract. The multifactorial pathophysiology of IBD is commonly explained as an abnormal interplay between genetic, immune, ... -
Molecular characterization of neuroblastoma tumors - a basis for personalized medicine.
(2012-05-24)Neuroblastoma is a very heterogeneous tumor, with a clinical course ranging from spontaneous regression to aggressive tumor growth. A proper stratification of the patients into different risk groups is therefore important ... -
Molecular factors influencing epithelial-mesenchymal transition in breast cancer
(2014-08-22)Epithelial-mesenchymal transition (EMT) is a developmental process defined by loss of epithelial characteristics and acquisition of mesenchymal phenotype. EMT or similar processes are also implicated in carcinoma cell ...