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Molecular characterization of neuroblastoma tumors - a basis for personalized medicine.


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Title: Molecular characterization of neuroblastoma tumors - a basis for personalized medicine.
Authors: Kryh, Hanna
E-mail: hanna.kryh@gu.se
Issue Date: 24-May-2012
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Genetics
Parts of work: I. Carén H, Kryh H, Nethander M, Sjöberg RM, Träger C, Nilsson S, Abrahamsson J, Kogner P, Martinsson T. High-risk neuroblastoma tumors with 11q-deletion display a poor prognostic, chromosome instability phenotype with later onset. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4323-8.
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II. Kryh H, Abrahamsson J, Jegerås E, Sjöberg RM, Devenney I, Kogner P, Martinsson T. MYCN amplicon junctions as tumor-specific targets for minimal residual disease detection in neuroblastoma. Int J Oncol. 2011 Nov;39(5):1063-71.
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III. Kryh H, Carén H, Erichsen J, Sjöberg RM, Abrahamsson J, Kogner P, Martinsson T. Comprehensive SNP array study of frequently used neuroblastoma cell lines; copy neutral loss of heterozygosity is common in the cell lines but uncommon in primary tumors. BMC Genomics. 2011 Sep 7;12:443.
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IV. Kryh H, Hedborg F, Øra I, Ambros P.F., Gartlgruber M, Kogner P, Martinsson T. Amplification of two regions on chromosome arm 12q defines a clinically distinct subgroup of high risk neuroblastoma patients. 2012 Unpublished manuscript
Date of Defence: 2012-06-08
Disputation: Fredagen den 8 juni 2012, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Neuroblastoma
Cancer
Tumor
SNP-array
Micro array
DNA copy number
Abstract: Neuroblastoma is a very heterogeneous tumor, with a clinical course ranging from spontaneous regression to aggressive tumor growth. A proper stratification of the patients into different risk groups is therefore important in order to provide the most suitable treatment for each patient. The primary aim of this thesis was therefore to further characterize the genes and mechanisms important for neuroblastoma development using genome wide copy number data from single nucleotide polymorphism (SNP)-a... more
ISBN: 978-91-628-8464-2
URI: http://hdl.handle.net/2077/28956
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses from Sahlgrenska Academy

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