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File | Description | Size | Format | |
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gupea_2077_28956_1.pdf | Thesis frame | 6341Kb | Adobe PDF | ![]() View/Open |
gupea_2077_28956_2.pdf | Abstract | 157Kb | Adobe PDF | ![]() View/Open |
Title: | Molecular characterization of neuroblastoma tumors - a basis for personalized medicine. |
Authors: | Kryh, Hanna |
E-mail: | hanna.kryh@gu.se |
Issue Date: | 24-May-2012 |
University: | University of Gothenburg. Sahlgrenska Academy |
Institution: | Institute of Biomedicine. Department of Medical Genetics |
Parts of work: | I. Carén H, Kryh H, Nethander M, Sjöberg RM, Träger C, Nilsson S, Abrahamsson J, Kogner P, Martinsson T. High-risk neuroblastoma tumors with 11q-deletion display a poor prognostic, chromosome instability phenotype with later onset. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4323-8. VIEW ARTICLE II. Kryh H, Abrahamsson J, Jegerås E, Sjöberg RM, Devenney I, Kogner P, Martinsson T. MYCN amplicon junctions as tumor-specific targets for minimal residual disease detection in neuroblastoma. Int J Oncol. 2011 Nov;39(5):1063-71. VIEW ARTICLE III. Kryh H, Carén H, Erichsen J, Sjöberg RM, Abrahamsson J, Kogner P, Martinsson T. Comprehensive SNP array study of frequently used neuroblastoma cell lines; copy neutral loss of heterozygosity is common in the cell lines but uncommon in primary tumors. BMC Genomics. 2011 Sep 7;12:443. VIEW ARTICLE IV. Kryh H, Hedborg F, Øra I, Ambros P.F., Gartlgruber M, Kogner P, Martinsson T. Amplification of two regions on chromosome arm 12q defines a clinically distinct subgroup of high risk neuroblastoma patients. 2012 Unpublished manuscript |
Date of Defence: | 2012-06-08 |
Disputation: | Fredagen den 8 juni 2012, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3 |
Degree: | Doctor of Philosophy (Medicine) |
Publication type: | Doctoral thesis |
Keywords: | Neuroblastoma Cancer Tumor SNP-array Micro array DNA copy number |
Abstract: | Neuroblastoma is a very heterogeneous tumor, with a clinical course ranging from spontaneous regression to aggressive tumor growth. A proper stratification of the patients into different risk groups is therefore important in order to provide the most suitable treatment for each patient. The primary aim of this thesis was therefore to further characterize the genes and mechanisms important for neuroblastoma development using genome wide copy number data from single nucleotide polymorphism (SNP)-a... more |
ISBN: | 978-91-628-8464-2 |
URI: | http://hdl.handle.net/2077/28956 |
Appears in Collections: | Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet Doctoral Theses from Sahlgrenska Academy |