• Infant microbiota and short chain fatty acids - relation to lifestyle and effect on health 

  Gio-Batta, Monica (2023-09-21)

  The commensal microbiota has both beneficial and negative effects on the host. It is a source of infectious and inflammatory microorganisms, but may also provide immune stimulation during a critical period during early ...

• Genomic signatures in viruses 

  Gustafsson, Joel (2023-05-25)

  In an age of global pandemics, studying how viruses and their genomes evolve is of great importance. It has previously been found that the genomes of many eukaryotes and prokaryotes have specific preferences for nucleotides, ...

• lnclusion body myositis - Genetic, clinical, and epidemiological aspects 

  Lindgren, Ulrika (2023-05-16)

  The inflammatory myopathy inclusion body myositis (IBM) is characterized by progressive muscle weakness and dysphagia in individuals over 45 years of age. Muscle biopsy shows inflammatory infiltrates, vacuoles with protein ...

• Characterization of Epstein-Barr virus non-coding RNAs in infected cells 

  Xie, Guojiang (2023-05-16)

  Epstein-Barr virus (EBV) causes multiple types of lymphoid and epithelial malignancies. Unraveling the viral gene expression patterns in tumors and identifying interaction partners between EBV and host elements is crucial ...

• Targeting residual malignant cells in myeloid leukemia 

  Nilsson, Malin (2023-05-12)

  Malignant cells persisting during treatment prevent cure in many patients with myeloid leukemia. In acute myeloid leukemia (AML), the failure to eradicate the leukemic clone during conventional chemotherapy is associated ...

• Unconventional T cells in colon adenocarcinomas 

  Rodin, William (2023-05-05)

  Many factors influence the initiation and growth of tumours. The infiltration and activity of immune cells in the tumour microenvironment are widely recognised as key factors affecting the clinical outcome of cancer. In ...

• Genomic and transcriptomic profiles in chronic hepatitis B infection 

  Ringlander, Johan (2023-05-04)

  Chronic infection with hepatitis B virus (HBV) affects >250 million people globally and is the most common cause of hepatocellular carcinoma and liver cirrhosis worldwide. Approximately one million deaths each year are ...

• Brain tumors in children - National population-based studies on classification, diagnostics and long-term follow-up 

  Habib Schepke, Elizabeth (2023-05-02)

  Although the prognosis for pediatric tumors of the central nervous system (CNS) has improved over time it is urgent to reduce mortality and improve long-term quality of life for survivors. With this aim, the first step is ...

• The functional role of the MUC17-based glycocalyx 

  Jäverfelt, Sofia (2023-04-27)

  Our gastrointestinal tract harbors trillions of bacteria that are chemically and spatially separated from the intestinal epithelium. Maintaining an intact mucosal barrier is essential as increased bacterial contact is ...

• Clinical significance of immunohistochemistry in breast cancer diagnostics 

  Janeva, Slavica (2023-04-27)

  For patients with breast cancer, modern patient-tailored treatment depends on tumor- specific characteristics, i.e., estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 (HER2), and the ...

• Pathogenic mechanisms affecting mitochondrial DNA replication and transcription 

  Singh, Meenakshi (2023-04-24)

  Mitochondria are cytoplasmic organelles fundamental to life and health. In mitochondria, energy from the food we eat is converted into adenosine triphosphate (ATP), which in turn is used as a source of chemical energy to ...

• Biochemical studies of mitochondrial DNA maintenance and topology 

  Erdinc, Direnis (2023-04-14)

  Mitochondria are crucial organelles in eukaryotic cells that produce the majority of adenosine trisphosphate used by cells as an energy currency to drive metabolic processes. Due to the endosymbiotic origin of mitochondria, ...

• Antibiotic use and respiratory pathogens with focus on Streptococcus pneumoniae in Tanzanian children 

  Emgård, Matilda (2023-03-30)

  This thesis describes the epidemiology of Streptococcus pneumoniae (pneumococci) and other respiratory pathogens after introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) and further portrays antibiotic ...

• Patient-derived scaffolds as a 3D model for breast cancer 

  Gustafsson, Anna (2023-02-17)

  Breast cancer is the most common cancer form in women worldwide. Many patients will have recurrent disease and more efficient targeted therapies are needed. The tumor microenvironment is a heterogenous complex mix of cells ...

• Defining the pathways involved in spatial protein quality control in Saccharomyces cerevisiae 

  Schneider, Kara Linda (2022-11-21)

  Proteins need to be folded into specific three-dimensional conformations to be functional. An extensive network of factors, the protein quality control (PQC) machinery, ensures that the cell maintains a healthy proteome ...

• On gastrointestinal viral infections 

  Beck-Friis, Thomas (2022-11-10)

  Gastrointestinal viral infections cause considerable morbidity and mortality worldwide. Many factors influencing clinical presentation, disease severity, epidemiology, and transmission are not fully understood. The aims ...

• Aloe barbadensis Mill. as a therapeutic option for irritable bowel syndrome – properties, bioactivity and mode of action 

  Ahluwalia, Bani (2022-11-08)

  Irritable bowel syndrome (IBS) is a chronic and prevalent functional gastrointestinal disorder, with an incompletely understood pathophysiology. Because of the disease complexity and heterogeneity, the currently available ...

• BiolDentification of Alk-associated signaling complexes 

  Uçkun, Ezgi (2022-10-25)

  Anaplastic lymphoma kinase (Alk) is a receptor tyrosine kinase (RTK) of the insulin receptor family. Alterations in human ALK signaling have been implicated in multiple malignancies including pediatric neuroblastoma. In ...

• Genetic studies of craniosynostosis with focus on syndromic forms 

  Topa, Alexandra (2022-10-21)

  Craniosynostosis (CS) represents the premature closure of skull sutures and affects ~1 in 2500 children. Untreated CS can lead to significant complications in craniofacial and psychomotor development. The only treatment ...

• Molecular biosignatures and gut-barrier alterations in inflammatory bowel diseases 

  Moraes Holst, Luiza (2022-08-23)

  Inflammatory bowel diseases (IBD) are chronic immune-mediated disorders affecting the gastrointestinal tract. The multifactorial pathophysiology of IBD is commonly explained as an abnormal interplay between genetic, immune, ...

View more