• Molecular and genetic studies of DLG2 in neuroblastoma and colorectal cancer 

  Keane, Simon

  Neuroblastoma is one of the most common extra cranial solid tumors in children. It is one of the most common causes of death amongst the pediatric malignancies. There is however a large difference between the low risk ...

• lntestinal microenvironment, epithelial barrier interactions and human milk oligosaccharide supplementation in irritable bowel syndrome 

  Iribarren Gómez, Cristina

  Alterations of the microbiota-host interactions at the mucosal border may be of importance in symptom generation in irritable bowel syndrome (IBS), a disorder of gut-brain interaction. Hence, microbiota-targeted interventions ...

• ReCREating BRAF-driven thyroid and lung cancer in mice 

  Schoultz, Elin

  Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer with a 3:1 female/male incidence. PTC is caused by oncogenic BRAF mutation encoding BRAFV600E in 50% of cases. Prognosis is mostly excellent post- ...

• Deregulated epigenetics and cancer stem cells in brain tumours 

  Wenger, Anna

  Glioblastoma (GBM) is an incurable brain tumour with dismal prognosis as the median survival for afflicted patients is only 8 months. Aberrations of epigenetic processes, which govern gene expression, are involved in cancer, ...

• Molecular and structural studies of proteins required for mitochondrial DNA maintenance 

  Pardo Hernández, Carlos

  Mitochondria are membrane-bound organelles that produce the majority of ATP used to drive metabolic processes in eukaryotic cells. A unique feature of mitochondria is the existence of a separate mitochondrial DNA (mtDNA), ...

• 3D Printed scaffolds as cancer microenvironment medels for drug discovery 

  Rosendahl, Jennifer

  Cancer is one of the most common diseases in the modern world and major efforts are made globally to develop new diagnostics and treatments. It originates from a cell which, at some point, has begun to divide and grow ...

• Next generation molecular diagnostics using ultrasensitive sequencing 

  Filges, Stefan

  Massively parallel sequencing enables the exploration of the genetic heterogeneity within microbial, viral and tumor cell populations. Detecting circulating tumor DNA in blood and other body fluids has the potential to ...

• A Study of Eosinophils – From the Human Thymus to Eosinophilic Esophagitis 

  Albinsson Högberg, Sofie

  Eosinophils are cells of the innate immune system. They primarily reside within tissues and are most numerous in the gastrointestinal tract but are absent from the healthy esophagus. During the inflammatory disease ...

• On the role of Natural Killer cell immunogenetics for the outcome of immunotherapy in acute myeloid leukemia 

  Hussein, Brwa (2022-02-14)

  Numerous studies have revealed that natural killer cells have fundamental roles as effector cells in myeloid leukemias. Thus, understanding NK cell-related biomarkers that influence clinical outcome are warranted. This ...

• Genomic mutational heterogeneity in cancer. lmproved models and tools for driver gene detection 

  Boström, Martin (2022-01-19)

  Cancer is a disease that is strongly related to evolution, as mutations that confer a benefit to individual cells face positive selection and eventually lead to tumorigenesis. As such, the search for genes that drive cancer ...

• On HIV in the elderly and vitamin B metabolism in HIV infection 

  Tyrberg, Erika (2022-01-17)

  The evolution of the human deficiency virus (HIV) field is unparalleled in the history of infectious diseases. From the first cases in the beginning of the 1980s, when an HIV diagnosis was a death sentence, through the ...

• T cells in colon cancer; migration and effector functions 

  Szeponik, Louis (2021-12-16)

  Immune cells are recognised as one of the main players in the tumor microenvironment and targeted by many new cancer therapies. Regulatory T cells (Treg) can suppress tumor infiltrating lymphocytes which are associated ...

• Proteostasis beyond chaperones - Auxiliary systems in the management of damaged proteins 

  Josefson, Rebecca (2021-11-25)

  Aging entails loss of functionality and increased risk of death, even for unicellular organisms, such as the yeast Saccharomyces cerevisiae. On a cellular level, aging is accompanied by an accumulation of harmful aging ...

• FET fusion oncoproteins in sarcoma tumorigenesis - lnteractions with the SWI/SNF chromatin remodeling complex and epigenetic effects 

  Lindén, Malin (2021-11-23)

  The FET family of fusion oncoproteins containing the N-terminal of either FUS, EWSR1 or TAF15 together with a transcription factor partner is the characteristic oncogenic driver of more than 20 types of sarcoma and leukemia, ...

• A search for prognostic biomarkers in diffuse large B-cell lymphoma with proteomics and immunohistochemistry 

  Bram Ednersson, Susanne (2021-11-18)

  Diffuse large B-cell lymphoma (DLBCL), the most common lymphoma in the Western world, can by gene expression profiling or immunohisto-chemistry (IHC), be divided into two subgroups according to its “cell-of-origin”. The ...

• Investigating ALK inhibitors alone or in combination as therapeutic options for ALK-positive neuroblastoma 

  Alam, Muhammad Wasi (2021-11-16)

  Neuroblastoma (NBL) is the third most common pediatric cancer after leukemia and cranial tumours and accounts for around 15% of death in pediatric malignancy. NBL develops due to the poorly differentiated progenitor cells ...

• The Role of FCGBP in Mucus - Structure, Processing and Function 

  Ehrencrona, Erik (2021-10-26)

  In this thesis, a bottom-up approach was used to study the IgG Fc-binding protein (FCGBP), which next to the MUC2 mucin is the second main component of secreted mucus in small intestine and colon. FCGBP is also found in ...

• Computational studies of mutational sequence signatures in cancer genomes 

  Lindberg, Markus (2021-10-08)

  Cancer typically forms when mutational processes modify key cancer driver genes, resulting in positive selection and tumor growth. As such, mutational processes are at the core of the disease. Trinucleotide mutational ...

• The impact of the progranulin-sortilin axis on breast cancer stem cell activity and patient outcome 

  Berger, Karoline (2021-08-18)

  Breast cancer is the most common cancer in women worldwide. Still today, despite current breast cancer therapies, many patients experience treatment resistance and relapse, which are believed to be due to failure in targeting ...

• Pan-cancer study of transcriptional responses to oncogenic somatic mutations 

  Ashouri, Arghavan (2021-05-27)

  Cancer cells typically carry acquired somatic mutations in key cancer driver genes, which can be identified on the basis of recurrence in cancer cohorts. Such mutations may cause aberrant protein activity and altered gene ...

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