• Biomarker profiling in sepsis diagnostics 

  Irani Shemirani, Mahnaz (2024-11-28)

  Effective and timely antibiotic therapy for sepsis requires a thorough understanding of the types and molecular characteristics of bacterial strains. Therefore, we investigated diagnostic strategies to facilitate faster ...

• The roles of RNA m6A modification in disease mechanisms of high-risk neuroblastoma 

  Thombare, Ketan (2024-11-21)

  Epitranscriptomics involves covalent modifications of RNA bases, with N6-methyladenosine (m6A) being one of the most abundant and functionally characterized. This modification plays a key role in RNA metabolism, cellular ...

• Tumor metastasis: mechanisms and prevention 

  Paul, Sanchari (2024-11-07)

  Metastatic spread of tumor cells accounts for the majority of cancer-related deaths. We have developed cancer vaccines based on the immunostimulatory adjuvant cholera toxin A1 (CTA1), including vaccines that deliver tumor ...

• Novel signaling and treatment regimes in Anaplastic Lymphoma Kinase driven neuroblastoma models 

  Borenäs, Marcus (2024-11-04)

  In this thesis we aimed to unravel the importance of Alkal2 in neuroblastoma with the aid of preclinical murine models. We tested the hypothesis that Alkal2 can potentiate murine MYCN-driven neuroblastoma in absence ...

• ldentification of viruses, their viability and purification in drinking water 

  Saguti, Fredy (2024-10-14)

  This thesis aimed to identify viruses commonly found in water sources and assess the efficiency of water barriers in viral reduction at drinking water treatment plants (DWTPs) over time. Cell culture assays and molecular ...

• Artificial intelligence in assessment of skin tumours in digital pathology 

  Siarov, Jan (2024-10-14)

  The rising incidence of skin cancers has led to an increased burden on dermatopathology laboratories. The advent of digitalization offers the opportunity to integrate artificial intelligence (AI) into digital pathology ...

• Outcomes of chronic and vertically acquired occult hepatitis B 

  Eilard, Anders (2024-09-26)

  Background: Chronic hepatitis B virus (HBV) infection is one of the major chronic infections and still in 2017 the most common cause for liver cirrhosis and hepatocellular carcinoma (HCC, liver cancer) in the world. Occult ...

• Profiling Circulating T cells and Tumor Landscape for Predicting Responses to PD-1 blockade in Patients with Non-Small Cell Lung Cancer 

  Dutta, Nikita (2024-09-05)

  Immune checkpoint blockade (ICB) has significantly improved outcomes in non-small cell lung cancer (NSCLC), yet only a subset of patients achieves durable responses. This underscores the need for effective methods to assess ...

• lnvestigating the functions of Anaplastic Lymphoma Kinase in neuronal tissues 

  Sukumar, Sanjay Kumar (2024-08-23)

  Receptors play an important role in cell-to-cell communication and are critical to the development and homeostasis of multicellular organisms. Anaplastic Lymphoma Kinase (ALK) is an evolutionary conserved receptor tyrosine ...

• Regenerative and immunological mechanisms in the human heart with an emphasis on heart failure 

  Sandstedt, Mikael (2024-05-08)

  The heart is a complex organ, with musculature, vasculature and many cell types interacting to achieve normal heart function. Chronic heart failure may be caused by factors such as hypertension and ischemic heart disease. ...

• Unveiling Cholera Toxin Binding and Intoxication using Enteroids and Site-Specific Mutants 

  Boucher, Andrew (2024-05-08)

  The diarrheal disease of cholera affects millions each year, causing over 100 000 deaths. This is caused by the bacteria Vibrio cholerae which produces the highly efficient Cholera toxin (CT) that exerts its function in ...

• Immune dysregulation - Regeneration and biology of the human kidney 

  De Luca, Francesco (2024-05-07)

  Kidney diseases can arise from immune dysregulation. One arm of this thesis revealed the relation between common variable immunodeficiency (CVID) or coeliac disease (CD) and immune-mediated renal diseases (IMRDs), the ...

• Molecular mechanisms of human presynapse assembly - role of liprin-alpha proteins in synapse organization and neurological disease 

  Berta, Marcó de la Cruz (2024-04-18)

  Synapses are the essential transmission units of neuronal circuits and represent the cornerstone of our unique cognitive abilities. During synapse formation, contact between two neurons induce the assembly of pre- and ...

• The Translocation t(7;12)(q36;p13) in Childhood Acute Myeloid Leukemia 

  Östlund, Anders (2024-04-11)

  The reciprocal translocation t(7;12)(q36;p13) gives rise to acute myeloid leukemia (AML) in infants and very young children. A fusion transcript MNX1::ETV6 is sometimes detected and an aberrant expression of MNX1 is ...

• NK cell recognition of malignant cells - a CRISPR approach to define novel mediators 

  Linnea, Kristenson (2024-03-14)

  Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system, capable of eliminating malignant cells. Their activity is intricately regulated through a balanced interplay between activating and inhibitory ...

• Multiomic profiling of leukemic stem cells in myeloid leukemia: implications for immunotherapy 

  Komic, Hana (2024-02-07)

  Despite the extensive array of therapies available for treating hematological malignancies, a major challenge in hemato-oncology lies in therapy resistance, which primarily is caused by residual resistant leukemic stem ...

• Understanding the role of the Parkinson’s associated kinase LRRK2 in inflammation and infection 

  Öberg, Maria (2024-01-16)

  The innate immune system, which mediates pathogen clearance and tissue healing, requires tight regulation to avert self-destruction. The endo-lysosomal system is best known as a network of vesicles that targets particles ...

• Immune Cell Profiling of Colorectal Cancers: Unravelling the Connection to Treatment Responses 

  Rezapour, Azar (2023-11-22)

  Understanding the interplay between tumor cells and the immune system holds the key to the development of more effective treatments for cancer patients. Therefore, we have emphasized our efforts on deciphering the intricacies ...

• Macrophages in Crohn's Disease: lnnate immune cellular and molecular mechanisms driving intestinal inflammation and fibrosis 

  Gorreja, Frida (2023-11-22)

  Macrophages and their interactions with the lamina propria and luminal microenvi-ronment are crucial in the pathogenesis of Crohn´s disease (CD), a chronic inflamma-tory disease with a strong inflammatory innate immune ...

• Neoehrlichiosis - latent infection of endothelium and immune defense 

  Wass, Linda (2023-11-14)

  This thesis is a study of the tick-borne pathogen Neoehrlichia (N.) mikurensis that causes the infectious disease neoehrlichiosis in humans. The disease affects both individuals with competent and suppressed immune defense ...

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