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Mass spectrometric analyses of proteoglycans - Novel tools for studying prohormones in insulin-producing cells


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Title: Mass spectrometric analyses of proteoglycans - Novel tools for studying prohormones in insulin-producing cells
Authors: Nikpour, Mahnaz
E-mail: mahnaz.nikpour@gu.se
Issue Date: 15-Dec-2020
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Laboratory Medicine
Parts of work: I. A glycoproteomic approach to identify novel proteoglycans. Noborn F, Nikpour M, Persson A, Sihlbom C, Nilsson J, and Larson G. Accepted for publication in Methods in Molecular Biology, Special volume on Glycosaminoglycans: Chemistry & Biology, 2020.
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II. Proteoglycan profiling of human, rat and mouse insulin-secreting cells. Nikpour M, Nilsson J, Persson A, Noborn F, Vorontsov E, and Larson G. Manuscript

III. Structural domain mapping of proteoglycan-derived glycosaminoglycans from rat insulinoma cells. Persson A, Nikpour M, Vorontsov E, Nilsson J, and Larson G. Manuscript

IV. Establishing B4galt7 knock-down clones of the rat INS-1 832/13 insulinoma cell line for studying biological effects of downregulation of GAG biosynthesis. Nikpour M, Madsen TD, Satir DM, Gomez Toledo A, Nilsson A, Persson A, Noborn F, Schjoldager KT, and Larson G. Manuscript
Date of Defence: 2020-12-18
Disputation: Fredagen den 18 december 2020, kl. 13.00, Hörsal Europa, Wallenberg Conference Center, medicinaregatan 20
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: proteoglycan
glycosaminoglycan
mass spectrometry
secretory granule
prohormones
CRISPR/Cas9
Abstract: Proteoglycans (PGs) are proteins that carry one or more negatively charged glycosaminoglycan (GAG) chains. Proteoglycans have been identified in essentially all multicellular organisms, and are implicated in a wide range of biological and pathological processes. To further decipher the influence of GAG glycosylation on biological and pathological events in humans, detailed structural characterization of PGs/GAGs is needed. However, studying the PGs/GAGs is very challenging and has been ham... more
ISBN: 978-91-8009-124-4 (Print)
978-91-8009-125-1 (PDF)
URI: http://hdl.handle.net/2077/66811
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

 

 

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