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Measurement of sensitivity to DNA damaging agents

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Title: Measurement of sensitivity to DNA damaging agents
Authors: Mathew T, Sherin
Issue Date: 18-Aug-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Clinical Chemistry and Transfusion Medicine
Parts of work: I. Sherin T. Mathew, Pegah Johansson, Yue Gao, Anders Fasth, Torben Ek, Ola Hammarsten. A flow cytometry assay that measures cellular sensitivity to DNA-damaging agents, customized for clinical routine laboratories, Clinical Biochemistry, 2016, 49:566–572

II. Pegah Johansson, Sherin T Mathew, Michaela Johansson, Ola Hammarsten. Validation of Cell division (CD) assay in measuring sensitivity of Fanconi Anemia cells. Manuscript, 2017

III. Sherin T. Mathew, Petra Bergstrom, Ola Hammarsten. Repeated Nrf2 stimulation using sulforaphane protects fibroblasts from ionizing radiation, Toxicology and applied pharmacology, 2014, 276: 188-194

IV. Sherin T. Mathew, Ola Hammarsten. Preconditioning cells with sulforaphane or bardoxolone methyl induces adaptation and cross-adaptation in human skin fibroblasts. Manuscript, 2017
Date of Defence: 2017-09-08
Disputation: Fredagen den 8 September 2017, kl. 9.00, Hörsal Kammaren, Blå stråket 5, Sahlgrenska Universitetssjukhuset/Sahlgrenska, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: intrinsic sensitivity
DNA damage
ionizing radiation
cell division
Abstract: There is a large inter-individual variation in intrinsic sensitivity in patients receiving treatment with DNA damaging agents. Cancer therapy exemplifies this problem where patients experience varying degree of normal tissue side effects in response to radiation or chemotherapy. For this reason, it is necessary to develop an assay to predict sensitivity of a patient prior to treatment with DNA damaging agents. This may allow more individualized treatment and improve the therapeutic index. In... more
ISBN: 978-91-629-0234-6 (PDF)
978-91-629-0235-3 (PRINT)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin



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