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Mechanisms of leukemia-induced immunosuppression


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Title: Mechanisms of leukemia-induced immunosuppression
Authors: Aurelius, Johan
E-mail: johan.aurelius@gu.se
Issue Date: 25-May-2012
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Infectious Medicine
Parts of work: I. Martner, A; Aurelius, J; Rydström, A; Hellstrand, K; Thorén, FB. Redox remodeling by dendritic cells protects antigen-specific T cells against oxidative stress. J Immunol 2011;187 6243-6248.
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II. Aurelius, J; Thorén, FB; Akhiani, A; Brune, M; Palmqvist, L; Hansson, M; Hellstrand, K; Martner, A. Monocytic AML cells inactivate anti-leukemic lymphocytes: role of NADPH oxidase/gp91phox expression and the PARP-1/PAR pathway of apoptosis. Blood 2012; Prepublished online May 1, 2012;
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III. Aurelius, J; Martner, A; Brune, M; Palmqvist, L; Hansson, M; Hellstrand, K; Thorén, FB. Remission maintenance in acute myeloid leukemia: impact of functional histamine H2 receptors expressed by leukemic cells. Submitted 2012

IV. Aurelius, J; Martner, A; Romero, AI; Riise, RE; Palmqvist, L; Brune, M; Hellstrand, K; Thorén FB. Chronic myeloid leukemic cells trigger poly(ADP-ribose) polymerase-dependent inactivation and cell death in lymphocytes. Submitted 2012.

V. Akhiani, AA; Aurelius, J; Movitz, C; Hellstrand, K; Thorén FB. Reactive oxygen species trigger ERK pathway-dependent parthanatos in cytotoxic lymphocytes. Submitted 2012.
Date of Defence: 2012-06-07
Disputation: Torsdagen den 7 juni, kl 09.00 i hörsal Tor Bjurström, Medicinaregatan 3B.
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Acute myeloid leukemia
Immunosuppression
Immunotherapy
Reactive oxygen species
PARP-1
NK cells
T cells
Abstract: This thesis aimed to define the role of reactive oxygen species (ROS), produced by the NADPH oxidase of myeloid cells, in the regulation of lymphocyte function with focus on ROS-induced dysfunction of natural killer (NK) cells and T lymphocytes in myeloid leukemia. In Paper I, a novel mechanism is presented by which specifically activated T lymphocytes evade inactivation by ROS after antigen presentation. Antigen-presenting dendritic cells were found to induce ROS-neutralizing thiols on the surf... more
ISBN: 978-91-628-8481-9
URI: http://hdl.handle.net/2077/28967
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses from Sahlgrenska Academy

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