Browsing Faculty of Science / Naturvetenskapliga fakulteten by Title
Now showing items 136-155 of 786
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Damage Segregation and Cellular Rejuvenation in Saccharomyces cerevisiae
(2015-11-06)The process of aging is defined as a time-dependent decline in cellular functionality, and aging is thought to have evolved as organisms were optimized for reproduction, at the cost of an imperfect repair and maintenance ... -
Decision making on indoor climate control in historic buildings: knowledge, uncertainty and the science-practice gap
(2016-09-09)Balancing use, preservation and energy use is a fundamental challenge for the whole heritage field. This is put to the point in designing and operating systems for indoor climate control in historic buildings, where competing ... -
Deep Learning Applications - From image analysis to medical diagnosis
(2021-05-11)Deep learning is a subcategory of machine learning and artificial intelligence. Instead of using explicit rules to perform a desired task as in standard algorithmic approaches, machine-learning algorithms autonomously learn ... -
Dekorativt 1700-talssmide: Att tolka formspråk genom hantverksanalys
(Hantverkslaboratoriet, Göteborgs universitet, 2022)Arbetet har genomförts som ett gästhantverkarprojekt vid Hantverkslaboratoriet, Göteborgs universitet. Det vidgar genom olika undersökande processer förståelsen av det svenska dekorativa smidet. Tre delundersökningar ingår: ... -
Design and Synthesis of Chalcone and Chromone Derivatives as Novel Anticancer Agents
(2012-01-23)This thesis comprises the design and synthesis of chalcone and chromone derivatives and their use in various biological applications, particularly as anticancer agents (targeting proteins associated with cancer pathogenesis) ... -
Design and Synthesis of Potential Aminoacyl-tRNA Synthetase Inhibitors
(2012-04-12)Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes present in all living organisms, their catalytic activity is involved in the translation of the genetic code into functional proteins and they are potential targets ... -
Design, Synthesis, and Evaluation of Functionalized Chroman-4-one and Chromone Derivatives. Somatostatin receptor agonists and Sirt2 inhibitors
(2012-10-04)Peptides are involved in many physiological processes such as regulation of blood-pressure, food intake, pain transmission and blood-glucose levels. They consist of amino acids that are connected through amide bonds which ... -
Designer magnetoplasmonics for adaptive nano-optics
(2017-08-24)Materials that provide real-time control of the fundamental properties of light at visible and near-infrared frequencies enable the essential components for future optical devices. Metal nanostructures that couple ... -
Detecting and Identifying Solution-structural Change in Photoactive Proteins
(2015-11-27)Conformational dynamics allow proteins to fulfil their biological roles, yet the understanding of these molecular machines is largely limited to structural snapshots. Time-resolved X-ray scattering provides a possible way ... -
Determine the developmental dynamics of primordial follicles in the mouse ovary
(2014-04-15)Ovarian follicles are the basic functional units of the mammalian ovary. Progressive activation of primordial follicles serves as the source of fertilizable ova. In this thesis, by generating the Foxl2-CreERT2 and ... -
Detoxification Mechanisms in Fish - Regulation and function of biotransformation and efflux in fish exposed to pharmaceuticals and other pollutants
(2012-10-26)It is likely that fish in their natural environment are exposed to mixtures of several pharmaceuticals as well as other pollutants. This may result in adverse effects which are augmented due to the chemical interactions. ... -
Development and application of Time-of-flight secondary ion mass spectrometry (ToF-SIMS) for skin permeation studies
(2024-01-08)The skin accounts for approximately 16% of human body weight, with a surface area of approximately 2 m2 in adults. It provides a physical barrier to the environment, maintains homeostasis by limiting the loss of water, ... -
Development and Application of ToF-SIMS for Clinical and Microbiological Analysis
(2023-02-15)The aim of the work of this thesis was to further the implementation of timeof-flight secondary ion mass spectrometry (ToF-SIMS) in biological analysis and to generate new knowledge from the samples analysed. ToF-SIMS is ... -
Development and Applications of Microfluidic Devices for Liver-on-a-Chip Studies
(2021-10-12)Modeling the human physiology in vitro is a challenging task, yet one of importance for the development of drugs and the study of diseases. To better address the complexities of human organs, microfluidic systems called ... -
Development and Evaluation of Web Applications for Investigating Candidate Genes in Rat Models of Complex Diseases
(2008-11-21)Many human diseases, such as rheumatoid arthritis and type 2 diabetes mellitus, have a very complex development, depending on both environmental and multiple genetic factors. By crossing inbred rat strains susceptible to ... -
Development and use of an optical pCO2 sensor in marine studies
(2013-10-04)Partial pressure of CO2 (pCO2) is one of the most important parameters, which are measured in the global ocean in conjunction with ocean acidification studies. It is also a parameter of great interest to aquaculture and ... -
Development and use of optical sensors in modern analytical chemistry
(2010-04-09)A successful long-term high resolution imaging experiment in marine sediments was performed (17 days within the sample; Paper I). The time correlated calibration procedure was evolved to include parametric sigmoidal and ... -
Development of Electrochemical Biosensors for Neurochemical Applications
(2018-01-04)The brain consists of billions of cells, including nerve cells, which have the ability of transforming an incoming electrical signal in to a chemical output by the release of neurotransmitters through a process called ... -
Development of Fluorescent Nucleobase Analogues - Intrinsically labelled nucleic acids for molecular binding investigations
(2019-09-04)This thesis focuses on the design, synthesis and utilization of fluorescent nucleobase analogues (FBAs). FBAs are an important class of compounds, used in the research of nucleic acids. The class of canonical FBAs, i.e. ... -
Development of novel serotonin 5-HT6 and dopamine D2 receptor ligands and MAO A inhibitors - Synthesis, structure-activity relationships and pharmacological characterization
(2013-09-05)It is known since the 1950s that enhancement of the levels of the monoamines dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) in the brain will relieve the symptoms of major depression, and ...