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Development and Applications of Microfluidic Devices for Liver-on-a-Chip Studies


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Title: Development and Applications of Microfluidic Devices for Liver-on-a-Chip Studies
Authors: Dalsbecker, Philip
E-mail: phdal91a@hotmail.com
philip.dalsbecker@physics.gu.se
Issue Date: 12-Oct-2021
University: Göteborgs universitet. Naturvetenskapliga fakulteten
Institution: Department of Physics ; Institutionen för fysik
Date of Defence: 2021-11-12
Disputation: Fredagen den 12 november 2021, kl. 9.00, PJ-salen, Institutionen för Fysik, Origovägen 6B
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: Microfluidics
Microphysiological system
Liver-on-a-Chip
Organ-on-a-chip
Hepatocytes
Induced pluripotent stem cells
iPSC
HepG2
LX-2
on-chip differentiation
PDMS
Microfabrication
Shear stress
Abstract: Modeling the human physiology in vitro is a challenging task, yet one of importance for the development of drugs and the study of diseases. To better address the complexities of human organs, microfluidic systems called organs-on-chips are being developed to emulate organ-specific environments for cell culture. Such systems are designed to recapitulate one or several key physiological features from the organ in question within an in vitro culture platform. This thesis describes the work perform... more
ISBN: 978-91-8009-488-7
978-91-8009-489-4
URI: http://hdl.handle.net/2077/69500
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för fysik

 

 

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