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Design and Synthesis of Potential Aminoacyl-tRNA Synthetase Inhibitors

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Title: Design and Synthesis of Potential Aminoacyl-tRNA Synthetase Inhibitors
Authors: Namro Redwan, Itedale
Issue Date: 12-Apr-2012
University: Göteborgs universitet. Naturvetenskapliga fakulteten
Institution: Department of Chemistry ; Institutionen för kemi
Parts of work: Paper I: Investigation, Optimisation and Synthesis of Sulfamoyloxy-linked Aminoacyl-AMP Analogues. Itedale Namro Redwan, Thomas Ljungdahl and Morten Grøtli. Tetrahedron, 2012, 68, 1507-1514.

Paper II: Development of a Solid-Phase Method for the Synthesis of 5ʹ-O-[N- (Acyl)sulfamoyl]Adenosine Derivatives. Itedale Namro Redwan, Hanna Jacobson Ingemyr, Thomas Ljungdahl, Christopher P. Lawson and Morten Grøtli. Submitted.

Paper III: Design, Synthesis and Biological Evaluation of Ribose-Free Isosteres of Aminoacyl-AMP. Itedale Namro Redwan, David Bliman, Andrés Palencia Carrilero, Stephen Cusack and Morten Grøtli. Manuscript.

Paper IV: A Mild and Efficient Method for Activation and Recycling of Trityl Resin. Itedale Namro Redwan and Morten Grøtli. Submitted.
Date of Defence: 2012-05-11
Disputation: Fredagen den 11 maj 2012, kl.9.00 Sal KC, Inst. för kemi och molekylärbiologi, Kemigården 4 (chalmersområdet), göteborg
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: Aminoacyl tRNA synthetases
Amino Acids
Protective Groups
Solid-Phase Chemistry
Molecular Modelling
Biological Evaluation
Abstract: Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes present in all living organisms, their catalytic activity is involved in the translation of the genetic code into functional proteins and they are potential targets for anti-infective agents. The first step in the biosynthetic pathway catalysed by aaRSs consists of activation of the corresponding amino acid by the reaction with ATP to form an aminoacyl-adenylate (aa-AMP), the key intermediate in the biosynthesis of proteins. As a result st... more
ISBN: 978-91-628-8445-1
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för cell- och molekylärbiologi
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet



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