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Detoxification Mechanisms in Fish - Regulation and function of biotransformation and efflux in fish exposed to pharmaceuticals and other pollutants


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/30452

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Title: Detoxification Mechanisms in Fish - Regulation and function of biotransformation and efflux in fish exposed to pharmaceuticals and other pollutants
Authors: Wassmur, Britt
E-mail: britt.wassmur@gu.se
Issue Date: 26-Oct-2012
University: University of Gothenburg. Faculty of Science
Institution: Department of Biological and Environmental Sciences ; Institutionen för biologi och miljövetenskap
Parts of work: I.Wassmur, B, Gräns, J, Norström, E, Wallin, M, Celander, M C (2012) Interactions of pharmaceuticals and other xenobiotics on key detoxification mechanisms and cytoskeleton in Poeciliopsis lucida hepatocellular carcinoma, PLHC-1 cell line. Toxicology in Vitro,
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II.Hasselberg, L, Westerberg, S, Wassmur, B, Celander, M C (2008) Ketoconazole, an antifungal imidazole, increases the sensitivity of rainbow trout to 17alpha-ethynylestradiol exposure. Aquatic Toxicology, 86, 256-64,
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III.Wassmur, B, Gräns, J, Kling, P, Celander, M C (2010) Interactions of pharmaceuticals and other xenobiotics on hepatic pregnane X receptor and cytochrome P450 3A signaling pathway in rainbow trout (Oncorhynchus mykiss). Aquatic Toxicology, 100, 91-100,
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IV.Wassmur, B, Gräns, J, Fernandez, M, Zanette J, Woodin, B R, Stegeman, J J, Wilson, J Y, Celander, M C Regulation of PXR, CYP3A and Pgp in PCB-resistant killifish (Fundulus heteroclitus) in New Bedford Harbor. Unpublished manuscript
Date of Defence: 2012-11-16
Disputation: Fredagen den 16 november 2012, kl. 10.00, Föreläsningssalen, Zoologihuset, Medicinaregatan 18A
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: fish
PXR
CYP1
CYP3
efflux
pharmaceuticals
drug interaction
Abstract: It is likely that fish in their natural environment are exposed to mixtures of several pharmaceuticals as well as other pollutants. This may result in adverse effects which are augmented due to the chemical interactions. Such chemical interactions are challenging to predict and increased knowledge on key detoxification mechanisms is needed. In human, adverse drug-interactions can arise by interactions with the pregnane X receptor (PXR) and the target genes cytochrome P450 3A4 (CYP3A4) and P-glyc... more
ISBN: 978-91-628-8540-3
URI: http://hdl.handle.net/2077/30452
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biologi och miljövetenskap

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