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Detecting and Identifying Solution-structural Change in Photoactive Proteins


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Title: Detecting and Identifying Solution-structural Change in Photoactive Proteins
Authors: Björling, Alexander
E-mail: alex.bjorling@gmail.com
Issue Date: 27-Nov-2015
University: University of Gothenburg. Faculty of Science.
Institution: Department of Chemistry and Molecular Biology ; Institutionen för kemi och molekylärbiologi
Parts of work: I. S. Niebling, A. Björling and S. Westenhoff, “MARTINI bead form factors for the analysis of time-resolved X-ray scattering of proteins”, J. Appl. Cryst. 47 (2014) 1190.
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II. A. Björling, S. Niebling, M. Marcellini, D. van der Spoel, and S. Westenhoff, “Deciphering solution scattering data with experimentally guided molecular dynamics simulations”, J. Chem. Theory Comput. 11 (2015) 780.
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III. H. Takala, A. Björling, O. Berntsson, et al., “Signal amplification and transduction in phytochrome photosensors”, Nature 509 (2014) 245.
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IV. A. Björling, O. Berntsson, H. Takala, et al., “Ubiquitous signaling in bacterial phytochromes”, J. Phys. Chem. Lett. 6 (2015) 3379.
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V. A. Björling, H. Lehtivuori, et al., “Structural photoconversion dynamics of a bacterial phytochrome”, In preparation.
Date of Defence: 2015-12-18
Disputation: Fredagen den 18 december 2015, kl 13.00, Carl Kylberg, Medicinaregatan 7B.
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: Protein dynamics
X-ray scattering
Light sensing proteins
Abstract: Conformational dynamics allow proteins to fulfil their biological roles, yet the understanding of these molecular machines is largely limited to structural snapshots. Time-resolved X-ray scattering provides a possible way of uncovering such dynamics, but hinges on the ability to trigger reactions, and most critically on the ability to interpret the resulting data. This thesis explores how such experiments can be carried out and analysed. First, a computational tool for the interpretation of ... more
ISBN: 978-91-628-9651-5
978-91-628-9650-8
URI: http://hdl.handle.net/2077/40649
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi

 

 

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