Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi by Title
Now showing items 438-457 of 480
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The dynamic nature of participation - Experiences, strategies and conditions for occupations in daily life amongst persons with late effects of polio
(2016-02-26)Aim: The overall aim of this thesis was to explore the conditions for daily occupations, and how these are reflected in the daily lives of people with the late effects of polio. Four studies (studies I–IV) are included in ... -
The gut-brain axis and alcohol-mediated behaviours: the amylin story
(2019-10-29)Alcohol use disorder (AUD) is a complex neuropsychiatric disorder with high rates of mortality and morbidity. The currently available pharmacotherapies show varied efficacy, leading to the investigation of new neurochemical ... -
The hemostatic pathway in ischemic stroke. Clinical studies of genetic variation and plasma protein measurements
(2012-08-28)Although stroke is a common cause of death and disability in adults, there are few studies on stroke compared to other common diseases. A stroke could be either ischemic or hemorrhagic, but even within these two groups, ... -
The impact of glucagon-like peptide-1 on the brain-reward system and beyond
(2015-09-09)Glucagon-like peptide-1 (GLP-1), produced in the intestine and the brain, regulates food intake and glucose metabolism. A GLP-1 based treatment is already approved for clinical use in type 2 diabetes patients, and recently ... -
The medical perspective in prescribing: measurements and educational strategies
(2021-08-18)Background and aims: Drug treatment is a keystone in modern healthcare and for safe prescribing of drugs, an overall medical perspective has to be applied, taking patient characteristics into account. For each medication, ... -
The Modified Version of the Postural Assessment Scale for Stroke Patients. Measurement properties and a longitudinal follow-up.
(2012-11-20)The Modified Version of the Postural Assessment Scale for Stroke Patients (SwePASS) Measurement properties and a longitudinal follow-up Carina U Persson Department of Rehabilitation Medicine, Institute of Neuroscience ... -
The neuromodulatory effect, safety and effectiveness of vagus nerve stimulation
(2017-03-22)Background Vagus nerve stimulation (VNS) is an adjunctive palliative neuromodulatory treatment for drug resistant epilepsy (DRE) and chronic depression. It has also been proposed as a treatment for many other conditions ... -
The neuropsychology of idiopathic normal pressure hydrocephalus
(2011-05-09)Idiopathic normal pressure hydrocephalus (iNPH) is characterised by an active distension of the cerebral ventricles due to inadequate absorption of cerebrospinal fluid (CSF) into the systemic circulation. The intracranial ... -
The neurovascular niche after irradiation to the developing brain
(2013-11-11)Radiotherapy is commonly used in the treatment of pediatric brain tumors but is unfortunately associated with debilitating negative effects, such as impaired memory and learning. Historically, vascular damage following ... -
The physiological processing of Alzheimer-associated amyloid beta precursor protein in human and animal-derived neuronal models
(2020-02-27)Alzheimer’s disease (AD) is characterized by cognitive impairment due to the loss of structure and/or function of neurons, and amyloid plaques composed of aggregated-amyloid beta (Aβ) peptides, primarily species ending at ... -
The postsynaptic protein neurogranin: a new item in the Alzheimer’s disease biomarker toolbox
(2019-03-13)Alzheimer’s disease (AD) is the most common form of dementia affecting more than 50 million people worldwide today and is characterised by progressive cognitive decline. One of the earliest events in AD, which is also ... -
The role of astrocytes in stroke, brain plasticity and neurogenesis
(2013-05-10)Astrocytes, one of the most abundant and heterogeneous cell types in the central nervous system, fulfill many important roles in the healthy and injured brain. This thesis investigates the role of astrocytes in the neurogenic ... -
The role of estrogen and superoxide dismutase in cataractogenesis
(2014-11-03)Cataract is an opacification of the eye lens, constituting the major cause of blindness globally. Oxidative stress is a key factor in the formation of cataract and female gender is a known risk factor for age-related ... -
The role of glycoproteins in glomerular pathophysiology
(2021-09-01)Chronic kidney disease (CKD) is increasing worldwide and has a prevalence of around 10%. With time patients are at risk of losing their renal function and will need dialysis or transplantation for survival. There are no ... -
The role of microglia in Alzheimer's disease - Investigating mechansims regulating amyloid-β clearance
(2016-05-31)Alzheimer’s disease (AD) is the most common form of dementia today. The disease is characterized by the presence of amyloid plaques and neurofibrillary tangles in the brain, accompanied by a progressive neurodegeneration ... -
The role of neonatal immunity in preterm brain injury
(2016-11-23)Perinatal brain injury is an important cause of mortality and morbidity and is associated with neurological disabilities such as those seen in cerebral palsy. Prematurity, especially in combination with very low birth ... -
The role of the alpha 7 nicotinic acetylcholine receptor in inflammation and brain injury
(2022-01-13)The alpha 7 nicotinic acetylcholine receptors (α7nAChR) are expressed in the nervous system as well as on peripheral immune cells where it participates in the cholinergic anti-inflammatory pathway. Inflammation is a common ... -
The Role of the Autonomic Nervous System in Atherosclerosis - Targeting the Cholinergic Anti-inflammatory Pathway in Humans and Mice
(2017-01-20)The autonomic nervous system (ANS) has been implicated in numerous atherosclerosis-induced cardiovascular disease, such as myocardial infarction and stroke. Although evidence suggests a relationship between autonomic ... -
The role of the complement system in ischemic stroke and neural plasticity
(2013-10-29)Evidence from experimental animal studies suggests that complement activation in the brain is a “double-edged sword” as it exerts beneficial or detrimental effects depending on the context. Here, we assessed whether ... -
The role of the human C-tactile system in affective somatosensation and pain
(2014-02-21)Affective touch perception in humans is a complex construct of input from mechanoreceptive afferents, current homeostatic state and contextual factors. Previously, a relationship has been identified between the pleasantness ...