Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi by Title
Now showing items 115-134 of 477
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Defense-related inhibition of sympathetic nerve activity: Insights from neuroimaging and monozygotic twins on related cortical processes and clinical potential
(2021-05-27)This thesis investigates a physiological phenomenon observed in the peripheral sympathetic nervous system in response to various stressors and tries to bring it closer to clinical research. Sudden surprising stimulation ... -
Dementia and other mental disorders among 95-year olds
(2008-04-17)The aims of this study were to estimate the prevalence of mental disorders and age related differences in the very elderly. In addition, five-year mortality after age 95 in relation to dementia and cognitive function in ... -
Dendritic cells in cancer immunotherapy
(2011-02-16)Dendritic cells (DCs) play a central role in the initiation and regulation of innate and adaptive immune responses and have increasingly been applied as vaccines for cancer patients. Ex vivo generation and antigen loading ... -
Depression among Swedish 70-year-olds - Sex differences from a gender perspective
(2020-04-28)Depression is one of the leading causes of global burden of disease. Due to increased life expectancy, late-life depression is an escalating public health issue. The prevalence is reported to be almost twice as high among ... -
Derivation, propagation and differentiation of human stem and progenitor cells
(2009-08-17)Neuronal loss is a common feature of many neurological disorders, including stroke, Parkinson’s disease, Alzheimer’s disease and traumatic brain injury. Human embryonic stem cells (hESCs) and hESC-derived neural progenitors ... -
Deriving biomarkers from computed tomography using deep learning
(2022-09-23)X-ray computed tomography (CT) and magnetic resonance imaging (MRI) are widely used structural neuroimaging modalities. For brain atrophy assessment and volumetric quantification using automated methods, MRI is the preferred ... -
Developing brain and systemic inflammation: a "Toll-like" link with consequences
(2017-05-24)The developing brain is vulnerable to external insults, and perinatal brain injury (PBI) is a major cause of life-long neurological syndromes such as cerebral palsy. Currently, no pharmaceutical intervention is available. ... -
Development and validation of upper extremity kinematic movement analysis for people with stroke. Reaching and drinking from a glass.
(2013-11-18)Kinematic analysis is a powerful method for objective assessment of movement performance, and is increasingly employed as outcome measure after stroke. The number of studies investigating natural, goal-oriented daily tasks ... -
Development of MALDI Mass Spectrometry Imaging Methods for Probing Spatial Lipid Biochemistry of Amyloid Plaques in Alzheimer's Disease
(2020-05-18)Alzheimer’s disease (AD) is the most prevalent cause of neurodegenerative dementia. Aggregation of amyloid β (Aβ) peptides into extracellular Aβ plaques is one of the major neuropathological features of AD. However, Aloysius ... -
Development of nursing programme to assist medical treatment in early onset Alzheimer's disease
(2013-01-25)Alzheimer´s disease (AD) is accompanied by neural degeneration with loss off dendrites and synapses. The ganglioside GM1 has been shown, but not in AD, to have positive influence on the nerve cells and stimulate growth of ... -
Developmental plasticity of the glutamate synapse: Roles of low frequency stimulation, hebbian induction and the NMDA receptor
(2010-01-26)The glutamate synapse is by far the most common synapse in the brain and acts via postsynaptic AMPA, NMDA and mGlu receptors. During brain development there is a continuous production of these synapses where those partaking ... -
Diagnostic Methods in Traumatic Brain Injury
(2017-04-20)Background: Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Early detection and quantification of TBI is important for acute management, for making early accurate prognoses of outcome, and ... -
Diagnostic, Prognostic, and Disease Activity Biomarkers in Multiple Sclerosis
(2023-03-15)Multiple sclerosis (MS) is the most common immune-mediated disease of the central nervous system. While benign cases exist, if left untreated, MS results in the compounding accumulation of disability. In the last two ... -
Dietary patterns among older adults - With focus on dementia and related biomarkers
(2022-10-18)Background and aim: Diet is a lifestyle factor that can influence healthy ageing and the risk of developing dementia. Studies investigating dietary patterns among older adults in relation to dementia, and dementia-related ... -
Differences in glutamatergic transmission onto interneurons and pyramidal cells in the rat hippocampus
(2010-09-03)In the human brain there are about 100 billion excitatory glutamatergic neurons and 10 billion inhibitory GABAergic neurons. During development, these neurons are synaptically wired together into neural networks, functionally ... -
Diffusion Tensor Imaging and Tractography in Epilepsy Surgery Candidates
(2008-04-25)In selected patients with medically refractory epilepsy, surgical treatment can render the patients seizure free or significantly reduce seizure frequency. Temporal lobe resection (TLR) for temporal lobe epilepsy (TLE) is ... -
Diffusion Tensor Imaging and Tractography of the Visual Pathways
(2016-08-31)The visual pathways are essential for human vision, stretching from the retinas of the eyes, via the anterior visual pathways and the optic radiations, to the primary visual cortex in the occipital lobe. Injury to these ... -
DIGIROP prediction models for severe retinopathy of prematurity
(2023-05-04)BACKGROUND: Retinopathy of prematurity (ROP), a preventable, potentially blinding eye disease, is primarily diagnosed in extremely preterm infants. Gestational age (GA) and birth weight (BW) are the most prominent risk ... -
Direct triaging to physiotherapist in primary care - development and evaluation of a triage model
(2019-04-05)Background: There is evidence that early contact with physiotherapists leads to advantages for patients with musculoskeletal disorders. Many patients, however, initially seek contact with general practitioners (GPs) within ... -
Discovering the capabilities of ageing persons who are born abroad: crossing norms, moving health promotion forward
(2015-01-30)To improve the possibilities for the whole population to take control over their health is an important goal for health promotion and public health. Yet, with improved possibilities for international migration and extended ...