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The physiological processing of Alzheimer-associated amyloid beta precursor protein in human and animal-derived neuronal models


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Title: The physiological processing of Alzheimer-associated amyloid beta precursor protein in human and animal-derived neuronal models
Authors: Satir, Tugce Munise
E-mail: tugce.munise.satir@gu.se
Issue Date: 27-Feb-2020
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry
Parts of work: Bergström P, Agholme L, Nazir FH, Satir TM, Toombs J, Wellington H, Strandberg J, Bontell TO, Kvartsberg H, Holmström M, Boreström C, Simonsson S, Kunath T, Lindahl A, Blennow K, Hanse E, Portelius E, Wray S, Zetterberg H. Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation.Scientific Reports 2016 Jul 7;
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Satir TM, Roselli S, Camacho R, Agholme L, Zetterberg H. Bergström P. Relationship between neuronal Aβ secretion and co-localization of APP with APP-cleaving secretases. Manuscript

Satir TM, Nazir FH, Vizlin-Hodzic D, Hardselius E, Blennow K, Wray S, Zetterberg H, Agholme L, Bergström P. Accelerated neuronal and synaptic maturation by BrainPhys medium increases Aβ secretion and alters Aβ peptide ratios from iPSC-derived cortical neurons. Scientific Reports 2020 Jan 17;
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Satir TM, Agholme L, Karlsson A, Karlsson M, Karila P, Illes S, Bergström P, Zetterberg H. Partial reduction of amyloid β production by β-secretase inhibitors does not decrease synaptic transmission. Submitted
Date of Defence: 2020-03-20
Disputation: Fredagen den 20 mars 2020, klockan 13.00, Torgny Segerstedtsalen, Universitetsbyggnaden Vasaparken, Universitetsplatsen 1, Göteborg
https://sahlgrenska.gu.se/forskning/aktuellt/evenemang/?eventId=70137077555
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Alzheimer’s disease
APP

human iPSCs
cortical neurons
BACE1
PSEN1
neuronal activity
neuronal differentiation
Abstract: Alzheimer’s disease (AD) is characterized by cognitive impairment due to the loss of structure and/or function of neurons, and amyloid plaques composed of aggregated-amyloid beta (Aβ) peptides, primarily species ending at the amino acid 42 (Aβ42), are one of the major neuropathological hallmarks of AD. Aβ peptides of different lengths are produced by sequential cleavage of amyloid beta precursor protein (APP) by α-, β- and γ- secretases. Aβ peptides are often considered “toxic”, but they are als... more
ISBN: 978-91-7833-790-3 (PRINT)
978-91-7833-791-0 (PDF)
URI: http://hdl.handle.net/2077/62690
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

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