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The role of the alpha 7 nicotinic acetylcholine receptor in inflammation and brain injury


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/69812

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Title: The role of the alpha 7 nicotinic acetylcholine receptor in inflammation and brain injury
Authors: Hammarlund, Maria
E-mail: maria.e.hammarlund@gmail.com
maria.hammarlund@gu.se
Issue Date: 13-Jan-2022
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Physiology
Parts of work: I. Polymorphisms in alpha 7 nicotinic acetylcholine receptor gene, CHRNA7, and its partially duplicated gene, CHRFAM7A, associate with increased inflammatory response in human peripheral mononuclear cells. Pattanaik B*, Hammarlund ME*, Mjörnstedt F*, Ulleryd MA, Zhong W, Uhlén M, Gummesson A, Bergström G and Johansson ME (Submitted) *Equal contributions

II. The selective alpha7 nicotinic acetylcholine receptor agonist AR-R17779 does not affect ischemia–reperfusion brain injury in mice. Hammarlund ME, Darsalia V, Mjörnstedt F, Pattanaik B, Mallard C, Rocha-Ferreira E, Patrone C and Johansson ME Bioscience Reports (2021) 41:6.
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III. The role of the alpha 7 nicotinic acetylcholine receptor in neonatal brain injury Hammarlund ME, Akar S, Karlsson A, Pattanaik B, Mjörnstedt F, Svedin P, Ardalan M, Rocha-Ferreira E, Ek J, Mallard C and Johansson ME (Manuscript)
Date of Defence: 2022-02-04
Disputation: Fredagen den 4 februari 2022, kl 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: alpha 7 nicotinic acetylcholine receptor
inflammation
brain injury
CHRNA7
CHRFAM7A
stroke
hypoxia ischemia
neonatal encephalopathy
human
PBMC
Abstract: The alpha 7 nicotinic acetylcholine receptors (α7nAChR) are expressed in the nervous system as well as on peripheral immune cells where it participates in the cholinergic anti-inflammatory pathway. Inflammation is a common component in the pathology of many diseases and injuries, including brain damage. Stroke and neonatal encephalopathy are common causes of mortality and morbidity worldwide in adults and infants, respectively, but lack sufficient treatment strategies. This thesis aims to deepen... more
ISBN: 978-91-8009-616-4 (PRINT)
978-91-8009-617-1 (PDF)
URI: http://hdl.handle.net/2077/69812
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

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