Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi by Title
Now showing items 211-230 of 481
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Inflammation and behavior following irradiation-induced injury in the developing brain
(2009-08-28)Radiotherapy is used in the treatment of pediatric brain tumors and is often associated with debilitating late effects, such as intellectual impairment. Areas in the brain harboring stem cells are particularly sensitive ... -
Inflammation and Cell Profileration Following Perinatal Brain Injury
(2010-08-30)Inflammation plays an important role in cerebral ischemic injury in the immature brain. The aim of the thesis was to investigate (1) the role of astrocyte activation and reactive gliosis in neonatal hypoxic-ischemic (HI) ... -
Inflammation and neuroprotective strategies in the immature brain after hypoxic-ischemic brain injury
(2008-05-13)Perinatal brain injury, as a result of hypoxia-ischemia (HI) or infection/HI, is a major cause of acute mortality and neurological morbidity in infants and children. The mechanisms of perinatal HI are not fully understood, ... -
Inflammation in experimental neonatal brain injury and in a clinical study of preterm birth; involvement of galectin-3 and free radical formation
(2010-01-08)Introduction; Intrauterine infection/inflammation is associated with preterm delivery (PTD) and severe neonatal morbidity. Inflammation is also important in the secondary neurotoxic cascade leading to perinatal brain injury. ... -
Inflammation in the immature brain: The role of Toll like receptors
(2011-10-28)Infection/inflammation and/or hypoxia-ischemia (HI) are major causes of perinatal brain injury. Toll-like receptors (TLRs), important components of innate immunity, have been shown to be involved in brain injury, both after ... -
Influence of serotonin on anxiety-like behavior in rat
(2018-11-05)It is well-established that serotonin is involved in the regulation of mood and behaviour, partly implied by the therapeutic effect of prolonged treatment with selective serotonin reuptake inhibitors (SSRI) on mood and ... -
Influence of serotonin-related genes on behavior and body weight
(2008-05-06)Rationale: The neurotransmitter serotonin has been implicated in the regulation of normal behaviors, including food intake, and attributed importance for a variety of common psychiatric conditions, including major depression, ... -
Interactions between nutrition, obesity and the immune system
(2009-11-22)There are several links between body fat and the immune system. For example, mice lacking activity of the pro-inflammatory interleukin-(IL)-1 and IL-6 develop obesity. Conversely, obesity is associated with adipose tissue ... -
Internationally adopted children with unilateral cleft lip and palate - longitudinal perspectives on speech production and language ability
(2020-05-13)Many children with cleft lip and palate have been adopted to Sweden. Most had had no palatal closure performed in their native countries and received their first palatal surgery in Sweden while acquiring a new first language. ... -
Intracranial Arachnoid Cysts. Epidemiology, Morphology and Surgical Outcome
(2016-05-13)Background: Intracranial arachnoid cysts (AC) are malformations of the arachnoid membrane. They may cause symptoms, either by obstruction of the CSF flow or by compression of adjacent neural tissues. The aim of this thesis ... -
Intracranial volume in neuroimaging: estimation and use in regional brain volume normalization
(2019-02-15)The aim of this thesis is to validate methods for estimation of intracranial volume in magnetic resonance images and to improve our understanding of the effect of intracranial volume normalization. To achieve the first ... -
Investigation of the pathophysiology of progression in multiple sclerosis: studies on cerebrospinal fluid biomarkers
(2013-04-23)Multiple Sclerosis (MS) is considered an autoimmune disease of the central nervous system (CNS). It usually starts with a relapsing remitting (RR) course that eventually transforms into progressive (P)MS, showing ... -
Investigations into the role of Epstein-Barr virus in the pathogenesis of multiple sclerosis
(2022-09-08)Epstein-Barr virus (EBV) infection may be a prerequisite for the development of MS. Virtually all MS patients have antibodies to Epstein Barr virus nuclear antigen 1 (EBNA1), compared to 90-95% of healthy individuals. ... -
Investigations of human cortical processing of gentle touch. A study with time-resolved electro-magnetic signal analysis
(2019-04-12)The present work summarizes investigations of the temporal correlates of brain activity elicited by gentle, moving touch on the hairy skin in healthy participants and in epilepsy patients. Light touch to the hairy skin ... -
Irradiation-induced injury to the juvenile brain -Roles of sex and inflammation
(2013-11-14)Radiotherapy is commonly used in the treatment of pediatric malignancies, but unfortunately it is associated with negative side effects, both long-term and short-term. Negative side effects following cranial irradiation ... -
It´s never too late
(2014-04-15)The overall aim of this thesis was to evaluate the effects of health-promoting and disease-preventive interventions on health and frailty in very old community-dwelling persons, and to explore the participants’ experiences ... -
Labile glutamate synaptic transmission onto CA1 hippocampal pyramidal neurons: regional, functional and developmental diversity
(2024-02-14)A single neuron in the brain receives tens of thousands of glutamate synapses from other neurons, and these synapses can differ in their properties depending on their role in the neural circuit, during brain development ... -
Language ability in patients with low-grade glioma - detecting signs of subtle dysfunction
(2017-11-17)Background: Low-grade glioma (LGG) is a slow-growing brain tumour often situated in or near areas involved in language and/or cognitive functions. Consequently, there is a risk that patients develop language impairments ... -
Language problems at 2½ years of age and their relationship with school-age language impairment and neuropsychiatric disorders
(2007-01-03)Background: International research has shown that language delay (LD) is associated with social, cognitive, emotional and/or behavioural deficiencies, but there is still a need for extended knowledge about LD at early age ... -
Late Neuropsychiatric Consequences of Stroke in the Elderly
(2006-11-07)Cognitive impairments and depression have considerable impacts on rehabilitation, quality of life and mortality after stroke. The understanding of cognitive and mood impairments in old and, in particular, very old stroke ...