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Inflammation in the immature brain: The role of Toll like receptors


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Title: Inflammation in the immature brain: The role of Toll like receptors
Authors: Stridh, Linnea
E-mail: linnea.stridh@neuro.gu.se
Issue Date: 28-Oct-2011
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Physiology
Parts of work: Paper 1. Regulation of Toll-like receptor 1 and -2 in neonatal mouse brain after hypoxia-ischemia Linnea Stridh, Peter L.P. Smith, Andrew S Naylor, Xiaoyang Wang and Carina Mallard J. Neuroinflammation 2011, 8:45
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Paper 2. Lipopolysaccharide Sensitizes Neonatal Hypoxic-Ischemic Brain Injury in a MyD88-Dependent Manner Xiaoyang Wang, Linnea Stridh, Wenli Li, Justin Dean, Anders Elmgren, Liming Gan, Kristina Eriksson, Henrik Hagberg and Carina Mallard J. Immunol. 2009;183;7471-7477
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Paper 3. TLR3 activation increases the vulnerability of the neonatal brain to hypoxia-ischemia Linnea Stridh, Xiaoyang Wang and Carina Mallard In manuscript

Paper 4. Regulation of Toll like receptors in choroid plexus and endothelial cells in the immature brain after inflammatory stimulation Linnea Stridh, Xiaoyang Wang, Holger Nilsson and Carina Mallard In manuscript
Date of Defence: 2011-11-11
Disputation: kl 9.00, Arvid Carlsson, Academicum, Medicinaregatan 3, göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: hypoxia-ischemia
immature brain
inflammation
innate immunity
Toll-like receptors
Abstract: Infection/inflammation and/or hypoxia-ischemia (HI) are major causes of perinatal brain injury. Toll-like receptors (TLRs), important components of innate immunity, have been shown to be involved in brain injury, both after infectious and endogenous, non-infectious, stimuli. The overall aim of this thesis was to study the expression of TLRs in the immature brain, choroid plexus and endothelial cells after inflammatory stimuli and/or HI, and to investigate the role of TLRs, their adaptor proteins... more
ISBN: 978-91-628-8352-2
URI: http://hdl.handle.net/2077/27809
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses from Sahlgrenska Academy

 

 

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