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Interactions between nutrition, obesity and the immune system

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Title: Interactions between nutrition, obesity and the immune system
Authors: Strandberg, Louise
Issue Date: 22-Nov-2009
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Physiology
Parts of work: I. Mice chronically fed high-fat diet have increased mortality and disturbed immune response in sepsis. Strandberg L, Verdrengh M, Enge E, Andersson N, Amu S, Önnheim K, Benrick A, Brisslert M, Bylund J, Bokarewa M, Nilsson S, Jansson JO. PLoS ONE 2009 Oct;4(10):e7605

II. Septic mortality is lower in mice fed a diet rich in polyunsaturated compared with saturated fatty acids. Strandberg L, Benrick A, Andersson N, Nilsson S, Jansson JO. Manuscript

III. Interleukin-1 system gene polymorphisms are associated with fat mass in young men. Strandberg L, Lorentzon M, Hellqvist A, Nilsson S, Wallenius V, Ohlsson C, Jansson JO. J Clin Endocrinol Metab 2006 Jul;91(7):2749-2754

IV. IL6 and IL1B polymorphisms are associated with fat mass in older men: the MrOS Study Sweden. Strandberg L, Mellstrom D, Ljunggren O, Grundberg E, Karlsson MK, Holmberg AH, Orwoll ES, Eriksson AL, Svedberg J, Bengtsson M, Ohlsson C, Jansson JO. Obesity (Silver Spring) 2008 Mar;16(3):710-713

Date of Defence: 2009-12-11
Disputation: Fredagen den 11 december 2009, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: obesity
fatty acids
fat mass
innate immunity
Abstract: There are several links between body fat and the immune system. For example, mice lacking activity of the pro-inflammatory interleukin-(IL)-1 and IL-6 develop obesity. Conversely, obesity is associated with adipose tissue inflammation and increased risk of infection. The aims of this thesis were to investigate (1) the effect of Western diet on Staphylococcus aureus (S. aureus)–induced mortality in mice; (2) if dietary fat composition affects mortality in S. aureus inoculated mice; and if IL-6 an... more
ISBN: 978-91-628-7954-9
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses from Sahlgrenska Academy



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