Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för medicin by Title
Now showing items 565-584 of 609
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Thymic exosomes - effects on selection and maturation of thymocytes
(2022-04-22)T cell tolerance is primarily shaped in the thymus, through direct and indirect presentation of self-antigens to developing T cells. Medullary thymic epithelial cells (mTECs), producing and expressing self-antigens, together ... -
Thymic studies. Investigations into the effects of childhood thymectomy, and characterization of thymic B cells and Hassall's corpuscles
(2019-04-23)This thesis focuses on the human thymus, a primary lymphoid organ responsible for the maturation of T cells. Progenitors arrive from the bone marrow and start to randomly assemble their T cell receptor (TCR) followed by a ... -
To return or not return? Predictive factors for return to work in persons with musculoskeletal disorders – prospective studies over a 10-year period
(2010-05-17)Background: Musculoskeletal disorders (MSD) are a major reason for sick leave and results in individual suffering as well as economical consequences for both the individual and society. It is important to study variables ... -
Tobaksrökens effekter på den lymfocytrekryterande cytokinen interleukin-16
(2011-11-09)Background: There is an increased number of CD8+ cells in the airways in chronic obstructive pulmonary disease (COPD) and also an increased number of CD4+ cells in severe COPD. The CD4 cell chemoattractant interleukin ... -
Translational genetics identifies a novel target to treat fatty liver disease
(2023-02-09)Fatty liver disease (FLD) is rapidly prevailing as the most common liver disease worldwide, with an estimated of one-quarter of the global population affected. Environmental and genetic determinants contribute to FLD ... -
Traumatic episodes related to the genocide period, mental health effects and perceived barriers to care facing young adults in Rwanda
(2016-05-09)Aims: To investigate mental health status in a Rwandan population aged 20-35 years, their associations with traumatic episodes experienced during the 1994 genocide and life time, and barriers to care as perceived by health ... -
Treatment of hypertension in women and men
(2014-08-29)Aims: The overall aim of the thesis was to investigate antihypertensive treatment in women and men. First, the aim was to analyze the scientifi c support for treatment recommendations in women and men. Second, the aims ... -
Treatment of whiplash associated disorders
(2010-08-30)Whiplash injuries seem to have a substantial impact on health. Half the affected patients have persistent pain and disability and significant costs are incurred to society, mainly due to inability to return to work. The ... -
Trends and determinants for graft survival among kidney transplanted patients in Sweden
(2024-02-07)According to literature, even after a successful kidney transplantation approximately 50% of the patients risk losing the transplant within ≈15 years. A return to dialysis or a new transplantation is then necessary. ... -
Turner syndrome. Relation between genotype and phenotype and long-term follow-up studies.
(2009-11-02)Turner syndrome (TS) is a chromosomal disorder with a prevalence of approximately 1/2 500 live female births. There is complete or partial absence of one of the two sex chromosomes, resulting in a genetic constellation ... -
Type 1 diabetes in adults: modern treatment and risk of major coronary events
(2018-01-22)Background: According to the National Diabetes Register (NDR) report (2016), 21.2% of adults with type 1 diabetes (T1D) achieve glycaemic targets measured with HbA1c (52 mmol / mol) and 20.1% of patients have very poor ... -
Tyrosine kinase Flt3/Flt3-ligand signaling in the modulation of immune responses in experimental arthritis
(2014-01-13)Rheumatoid arthritis (RA) is an autoimmune, chronic systemic inflammatory disorder that primarily affects flexible joints resulting in severe joint destruction and disability if left untreated. Today, advances in treatment ... -
Ultrasound assessment of carotid atherosclerosis focusing on plaque characteristics and changes over time
(2011-05-26)In a clinical perspective better methods to identify subjects at increased cardiovascular risk are needed. Atherosclerotic plaques of the carotid arteries with low echogenicity have been related to future clinical events. ... -
Ultrasound evaluation of atherosclerosis and other cardiovascular sources of cerebral embolism
(2008-01-18)The search for embolic sources has high priority in patients presenting with suspected cerebral embolism. Non-invasive cardiovascular ultrasound is frequently used to reveal the presence of carotid stenosis and cardiac ... -
Understanding the genetic architecture of fatty liver disease
(2022-11-29)Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease, ranging from simple steatosis to more severe conditions, namely non-alcoholic steatohepatitis (NASH), liver fibrosis, cirrhosis, ... -
Understanding the molecular mechanisms of bile acid receptor activation for the treatment of human liver disease
(2020-04-30)Farnesoid X receptor (FXR) is a nuclear transcription factor that is activated by bile acids and regulates bile acid homeostasis, glucose and lipid metabolism. FXR activation by a ligand has been identified as a therapeutic ... -
Unmet need for mental healthcare among men Sweden: Gendered pathways to care
(2022-02-02)Aim: Depression and anxiety disorders have a lifetime prevalence of about 10% among men in high-income countries but many do not seek and receive the care that they need. The aim of this thesis was to explore gendered ... -
Urinary Clara cell protein and alpha 1-microglobulin – biomarkers of changes in kidney and airway function
(2010-04-13)Validated biomarkers are useful tools for screening large populations. The benefit of screening may be improved risk assessment or early indications of adverse effects before detection or onset of symptoms. Screening is ... -
Utmattningssyndrom, identifikation, karakteristika och förlopp
(2014-05-09)Aim. The overall aim of the thesis was to study exhaustion disorder (ED) with respect to identification, characterisation and course of illness, as well as some properties of an instrument of self-rated ED (s-ED). Method. ... -
Utvecklad dialog om sexuell hälsa med fokus på unga kvinnor - en möjlighet vid det gynekologiska besöket
(2009-11-19)Background: Many women who have sexual problems or who have been subjected to sexual abuse do not seek help and health professionals often avoid raising such issues. The gynaecological encounter could be an opportunity ...