Search
Now showing items 1-5 of 5
Pathophysiological impact of targeting the ROS-p53 axis
(2014-10-21)
The goal of this PhD thesis was to define the importance of the interplay between reactive oxygen species (ROS) and their activation of the tumor suppressor p53 in development and disease. We addressed this question using ...
Effects of antioxidant supplementation on cancer progression
(2018-05-18)
Popular wisdom holds that antioxidants protect against cancer because they neutralize reactive oxygen species (ROS) and other free radicals which can otherwise cause cancer by damaging DNA. This has been the rationale ...
Molecular characterization of neuroblastoma tumors - a basis for personalized medicine.
(2012-05-24)
Neuroblastoma is a very heterogeneous tumor, with a clinical course ranging from spontaneous regression to aggressive tumor growth. A proper stratification of the patients into different risk groups is therefore important ...
Redox reactions in cancer: impact and regulation
(2018-09-28)
The reduction-oxidation (redox) reaction involves a change in the oxidation state of molecules where a molecule that donates an electron is oxidized and a molecule that accepts an electron is reduced. The NADPH oxidase of ...
Cell cycle regulation in cancer: A noncoding perspective
(2019-11-26)
The cell cycle progression is tightly regulated to ensure error-free cell replication. The complexity of the transcriptional machinery aids to function in a spatiotemporal pattern across different phases and genomic loci. ...