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Pathophysiological impact of targeting the ROS-p53 axis


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Title: Pathophysiological impact of targeting the ROS-p53 axis
Authors: Sayin, Volkan
E-mail: volkan.sayin@wlab.gu.se
Issue Date: 21-Oct-2014
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Biochemistry and Cell Biology
Parts of work: I. Sayin VI, Nilton A, Ibrahim MX, Agren P, Larsson E, Petit MM, Hulten LM, Stahlman M, Johansson BR, Bergo MO and Lindahl P. Zfp148 deficiency causes lung maturation defects and lethality in newborn mice that are rescued by deletion of p53 or antioxidant treatment. PLoS One 2013 8(2):e55720
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II. Nilton A*, Sayin VI*, Bondjers C, Agren P, Bergo MO and Lindahl P *Equal ContributionZfp148 deficiency reduces tumor formation in APCMin/+ mice in a p53-dependent manner. In manuscript

III. Sayin VI, Ibrahim MX, Larsson E, Nilsson JA, Lindahl P and Bergo MO. Antioxidants accelerate lung cancer progression in mice. Science Translational Medicine 2014 6(221):221ra15.
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IV. Sayin VI, Khan OM, Pehlivanoglu LE, Staffas A, Ibrahim MX, Asplund A, Agren P, Nilton A, Bergström G, Bergo MO, Borén J and Lindahl P. Loss of one copy of Zfp148 reduces lesional macrophage proliferation and atherosclerosis in mice by activating p53. Circulation Research 2014 115(9):781-9.
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Date of Defence: 2014-11-07
Disputation: Fredagen den 7 november 2014, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Antioxidants
Cancer
p53
ROS
atherosclerosis
Abstract: The goal of this PhD thesis was to define the importance of the interplay between reactive oxygen species (ROS) and their activation of the tumor suppressor p53 in development and disease. We addressed this question using molecular biology and biochemical techniques together with mouse genetics and bioinformatics. We have made two important discoveries: First, we show that antioxidant supplementation accelerates lung cancer progression in mice and the growth of human lung cancer cell lines. By... more
ISBN: 978-91-628-9199-2 (printed)
978-91-628-9201-2
URI: http://hdl.handle.net/2077/36746
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

 

 

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