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Redox reactions in cancer: impact and regulation


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Title: Redox reactions in cancer: impact and regulation
Authors: Grauers Wiktorin, Hanna
E-mail: hanna.grauers.wiktorin@gu.se
Issue Date: 28-Sep-2018
University: University of Gothenburg. Sahlgrenska Academy.
Institution: Institute of Biomedicine. Department of Infectious Diseases
Parts of work: I. Martner A, Grauers Wiktorin H, Lenox B, Ewald Sander F, Aydin E, Aurelius J, Thorén FB, Ståhlberg A, Hermodsson S, Hellstrand K. Histamine promotes the development of monocyte-derived dendritic cells and reduces tumor growth by targeting the myeloid NADPH oxidase. J Immunol 2015;194(10):5014-5021
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II. Grauers Wiktorin H, Nilsson MS, Kiffin R, Ewald Sander F, Lenox B, Rydström A, Hellstrand K, Martner A. Histamine targets myeloid-derived suppressor cells and improves the anti-tumor efficacy of PD-1/PD-L1 checkpoint blockade. Accepted for publication in Cancer Immunology Immunotherapy 2018

III. Kiffin R, Grauers Wiktorin H, Nilsson MS, Aurelius J, Aydin E, Lenox B, Nilsson JA, Ståhlberg A, Thorén FB, Hellstrand K, Martner A. Anti-leukemic properties of histamine in monocytic leukemia: The role of NOX2. Front Oncol 2018;8(JUN):218
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IV. Grauers Wiktorin H, Nilsson T, Aydin E, Hellstrand K, Palmqvist L, Martner A. Role of NOX2 for leukaemic expansion in a murine model of BCR-ABL1+ leukaemia. Br J Haematol 2018;182(2):290-294
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Date of Defence: 2018-10-19
Disputation: Fredagen den 19 oktober 2018, kl. 9.00, Hörsal Åke Göransson, Medicinaregatan 11
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Cancer
Immunotherapy
reactive oxygen species
NOX2
histamine dihydrochloride
myeloid-derived suppressor cells
checkpoint inhibition
acute myeloid leukemia
chronic myeloid leukemia
Abstract: The reduction-oxidation (redox) reaction involves a change in the oxidation state of molecules where a molecule that donates an electron is oxidized and a molecule that accepts an electron is reduced. The NADPH oxidase of myeloid cells, NOX2, is a major source of oxidants in the form of reactive oxygen species (ROS), which are short-lived oxygen derivatives. NOX2-derived ROS have been ascribed a pivotal role in the elimination of pathogens and may be toxic also to host cells and tissues. ROS may... more
ISBN: 978-91-7833-119-2 (PRINT)
URI: http://hdl.handle.net/2077/56884
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

 

 

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